Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Isaac Mohar"'
Autor:
Isaac Mohar, Brendan D. Stamper, Peter M. Rademacher, Collin C. White, Sidney D. Nelson, Terrance J. Kavanagh
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 377-387 (2014)
The mechanism by which acetaminophen (APAP) causes liver damage evokes many aspects drug metabolism, oxidative chemistry, and genetic-predisposition. In this study, we leverage the relative resistance of female C57BL/6 mice to APAP-induced liver dama
Externí odkaz:
https://doaj.org/article/4a4c70ebc1494997ba14a87ad8ef85b1
Autor:
Lin Chen, Gladys J Keitany, Xiaohong Peng, Claire Gibson, Isaac Mohar, Marissa Vignali, Ian N Crispe, Fusheng Huang, Ruobing Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102225 (2014)
Pre-erythrocytic malaria vaccines, including those based on whole-parasite approaches, have shown protective efficacy in animal and human studies. However few pre-erythocytic antigens other than the immunodominant circumsporozoite protein (CSP) have
Externí odkaz:
https://doaj.org/article/173fd53b9ab24a7db2f58966dd849f58
Autor:
Toby B. Cole, Gennaro Giordano, Aila L. Co, Isaac Mohar, Terrance J. Kavanagh, Lucio G. Costa
Publikováno v:
Journal of Toxicology, Vol 2011 (2011)
Glutathione (GSH) is a major player in cellular defense against oxidative stress. Deletion of the modifier subunit of glutamate cysteine ligase (GCLM), the first and the rate-limiting enzyme in the synthesis of GSH, leads to significantly lower GSH l
Externí odkaz:
https://doaj.org/article/e51606aff8ff457d990cc4c001ff6216
Esophageal cancers comprise about 1% of all cancers diagnosed in the US but are more prevalent in other regions of the world. Several regulatory agencies have classified asbestos as a known human carcinogen, and it is linked to multiple diseases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160df0864e3f8358d9af534fe028db9d
Autor:
Isaac Mohar, Sara A. Murray, Stefan H. I. Kappe, Ian N. Crispe, Jessica L. Miller, Katherine J. Brempelis, Ashley M. Vaughan
Publikováno v:
The Journal of Immunology. 194:2268-2279
The costimulatory molecule CD40 enhances immunity through several distinct roles in T cell activation and T cell interaction with other immune cells. In a mouse model of immunity to liver stage Plasmodium infection, CD40 was critical for the full mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7e10be8bdf02fb056b34020dda41bd
https://doi.org/10.4049/jimmunol.1401724
https://doi.org/10.4049/jimmunol.1401724
Autor:
Robyn L. Prueitt, Julie E. Goodman, Sonja N. Sax, Ke Zu, Sara Pacheco Shubin, Heather N. Lynch, Isaac Mohar, Christine T. Loftus
Publikováno v:
Environmental research. 160
To determine whether evidence indicates that short-term exposure to ambient concentrations of ozone in the United States can affect asthma severity, we systematically reviewed published controlled human exposure, epidemiology, and animal toxicity stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f852fec567ac011e8b09219d09d33cf4
https://pubmed.ncbi.nlm.nih.gov/29059621
https://pubmed.ncbi.nlm.nih.gov/29059621
Autor:
I. Nicholas Crispe, Landon Myer, Donald L. Sodora, Jo-Ann S. Passmore, Anneke C. Hesseling, Mark F. Cotton, Melanie A. Gasper, Heather B. Jaspan, Isaac Mohar, Tali Azenkot, Willem A. Hanekom
Publikováno v:
JCI Insight. 2
BACKGROUND. Bacillus Calmette-Guerin (BCG) vaccine is administered at birth to protect infants against tuberculosis throughout Africa, where most perinatal HIV-1 transmission occurs. We examined whether BCG vaccination alters the levels of activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b12540f0c4d15e2d577f778038385df
https://doi.org/10.1172/jci.insight.91963
https://doi.org/10.1172/jci.insight.91963
Multiple pathways drive the sterile injury response in the liver; however, it is unclear how the type of cells injured or the mechanism of injury activates these pathways. Here, we use a model of selective hepatocyte death to investigate sterile live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e42f1c9b97a5ce3baa34a0be3b2ccc0
https://europepmc.org/articles/PMC5391172/
https://europepmc.org/articles/PMC5391172/
Autor:
Jessica Wagoner, Silvia Giugliano, Hugo R. Rosen, Stephen J. Polyak, Derek Thirstrup, Erica S. Lovelace, I. Nicholas Crispe, Kui Li, Isaac Mohar, Wesley E. Smith, Jessica Brownell
Publikováno v:
Journal of Hepatology. 59:701-708
Background & Aims The pro-inflammatory chemokine CXCL10 is induced by HCV infection in vitro and in vivo , and is associated with outcome of IFN (interferon)-based therapy. We studied how hepatocyte sensing of early HCV infection via TLR3 (Toll-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5327df648638e3f5cbc0c960cfd253fc
https://doi.org/10.1016/j.jhep.2013.06.001
https://doi.org/10.1016/j.jhep.2013.06.001
Autor:
Hideo Takakusa, Edward J. Kelly, Terrance J. Kavanagh, Isaac Mohar, Sidney D. Nelson, Rüdiger Kaspera
Publikováno v:
Biochemical and Biophysical Research Communications. 420:54-60
Mitochondria are the primary locus for the generation of reactive nitrogen species including peroxynitrite and subsequent protein tyrosine nitration. Protein tyrosine nitration may have important functional and biological consequences such as alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b7036e57c460051e83bc7716fa0865
https://doi.org/10.1016/j.bbrc.2012.02.114
https://doi.org/10.1016/j.bbrc.2012.02.114