Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Isaac M. Chiu"'
Autor:
Nicole J. Yang, Dylan V. Neel, Liwen Deng, Michelle Heyang, Angela Kennedy-Curran, Victoria S. Tong, Jin Mo Park, Isaac M. Chiu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense. Bacillus anthracis Edema Toxin (ET) produc
Externí odkaz:
https://doaj.org/article/e240264f8dfc435faf6001284ed28aaf
Publikováno v:
Neurobiology of Pain, Vol 9, Iss , Pp 100056- (2021)
Nociceptor sensory neurons innervate barrier tissues that are constantly exposed to microbial stimuli. During infection, pathogenic microorganisms can breach barrier surfaces and produce pain by directly activating nociceptors. Microorganisms that li
Externí odkaz:
https://doaj.org/article/fad361649c394c69931f4074350dda16
Autor:
Kimbria J. Blake, Pankaj Baral, Tiphaine Voisin, Ashira Lubkin, Felipe Almeida Pinho-Ribeiro, Kelsey L. Adams, David P. Roberson, Yuxin C. Ma, Michael Otto, Clifford J. Woolf, Victor J. Torres, Isaac M. Chiu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-3
Externí odkaz:
https://doaj.org/article/12940086f7914bb98b02fd6144e957e5
Autor:
Isaac M. Chiu, Emiko T.A. Morimoto, Hani Goodarzi, Jennifer T. Liao, Sean O’Keeffe, Hemali P. Phatnani, Michael Muratet, Michael C. Carroll, Shawn Levy, Saeed Tavazoie, Richard M. Myers, Tom Maniatis
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 385-401 (2013)
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. A
Externí odkaz:
https://doaj.org/article/78258226a51b475595fe6c533751021b
Publikováno v:
Nature. 615:660-667
Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by
Autor:
Felipe A. Pinho-Ribeiro, Liwen Deng, Dylan V. Neel, Ozge Erdogan, Himanish Basu, Daping Yang, Samantha Choi, Alec J. Walker, Simone Carneiro-Nascimento, Kathleen He, Glendon Wu, Beth Stevens, Kelly S. Doran, Dan Levy, Isaac M. Chiu
Publikováno v:
Nature. 615:472-481
Publikováno v:
Immunological Reviews. 311:130-150
In the central nervous system (CNS), execution of programmed cell death (PCD) is crucial for proper neurodevelopment. However, aberrant activation of these pathways in adult CNS leads to neurodegenerative diseases including amyotrophic lateral sclero
Autor:
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C. Macbeth, Elyza A. Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S. Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M. Chiu, Jeffrey R. Moffitt, Ansel Hsiao, John J. Mekalanos, Christophe Benoist, Dennis L. Kasper
Publikováno v:
bioRxiv
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement component 3 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e123493ed381fc22f2f57e2ae0c488
https://europepmc.org/articles/PMC9915568/
https://europepmc.org/articles/PMC9915568/
Publikováno v:
Nat Rev Neurosci
Bidirectional communication between the peripheral nervous system (PNS) and the immune system is a crucial part of an effective but balanced mammalian response to invading pathogens, tissue damage and inflammatory stimuli. Here, we review how somatos
IntroductionPulpitis is associated with dental carries and can lead to irreversible pulp damage. As bacteria penetrate deeper into dentin and pulp tissue, a pulpal innate immune response is initiated. However, an understanding of the types of immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d584d12a3318215a5efebcc42a42ad
https://doi.org/10.1101/2023.01.15.524125
https://doi.org/10.1101/2023.01.15.524125