Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Isaac M. Adjei"'
Autor:
Isaac M. Adjei, Sharma Blanka
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 1, Pp 81-103 (2015)
Tumors are complex tissues that consist of stromal cells, such as fibroblasts, immune cells and mesenchymal stem cells, as well as non-cellular components, in addition to neoplastic cells. Increasingly, there is evidence to suggest that these non-neo
Externí odkaz:
https://doaj.org/article/4fa19d6fc3b14bf7a663360cf13a230e
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 205 (2018)
Bone metastases are common complications of solid tumors, particularly those of the prostate, breast, and lungs. Bone metastases can lead to painful and devastating skeletal-related events (SREs), such as pathological fractures and nerve compressions
Externí odkaz:
https://doaj.org/article/79165324dd9b49f7bdeac314b7323c73
Publikováno v:
Molecular Pharmaceutics. 18:2935-2946
The adoptive transfer of natural killer (NK) cells, which can recognize and obliterate cancer cells, provides a practical alternative to current treatment modalities to improve cancer patients' survival. However, translating NK cell therapies to trea
Publikováno v:
ACS Biomaterials Science & Engineering. 6:4179-4199
A critical hurdle associated with natural killer (NK) cell immunotherapies is inadequate infiltration and function in the solid tumor microenvironment. Well-controlled 3D culture systems could advance our understanding of the role of various biophysi
Publikováno v:
Nanoscale advances. 4(12)
The article uses in vitro models to show blood vessel influence on the protein corona’s (PC) composition. These results highlight the need to investigate the blood vessel architecture’s influence on the PC and their biological fate.
Autor:
Blanka Sharma, Nhan Tu, Jahnelle Jordan, Sheng Wei, Isaac M. Adjei, Thu Le Trinh, Wendy M. Kandell
Publikováno v:
Journal of Interdisciplinary Nanomedicine, Vol 4, Iss 4, Pp 98-112 (2019)
Natural killer (NK) cells are at the forefront of immunotherapies, as they have potent innate cytolytic effects on cancer cells. The success of NK cell therapies requires that they overcome immunosuppression in the tumor microenvironment. Tumors prod
Autor:
Blanka Sharma, Lorena Maldonado-Camargo, Huabei Jiang, Glendon Plumton, Jon Dobson, Hao Yang, Isaac M. Adjei, Carlos Rinaldi
Publikováno v:
Drug Delivery and Translational Research. 9:652-666
Strategies that control the differentiation of mesenchymal stem cells (MSC) and enable image-guided cell implantation and longitudinal monitoring could advance MSC-based therapies for bone defects and injuries. Here we demonstrate a multifunctional n
Autor:
Peter S. McFetridge, Olivia L. Lanier, Christopher Nacea, Blanka Sharma, Camryn Lewis, Isaac M. Adjei, Dayita Wable, Jon Dobson, Joseph M Ficarrotta
Publikováno v:
Macromolecular bioscience. 21(1)
Bone loss through traumatic injury is a significant clinical issue. Researchers have created many scaffold types to mimic an extracellular matrix to provide structural support for the formation of new bone, however functional regeneration of larger s
Publikováno v:
Journal of Controlled Release. 232:83-92
Advanced-stage prostate cancer usually metastasizes to bone and is untreatable due to poor biodistribution of intravenously administered anticancer drugs to bone. In this study, we modulated the surface charge/composition of biodegradable nanoparticl
Publikováno v:
Osteoarthritis and Cartilage. 27:S81-S82