Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Isaac M. Adanyeguh"'
Autor:
Pramod Kumar Pisharady, Lynn E. Eberly, Isaac M. Adanyeguh, Georgios Manousakis, Gaurav Guliani, David Walk, Christophe Lenglet
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Abstract Background Recent advances in MRI acquisitions and image analysis have increased the utility of neuroimaging in understanding disease-related changes. In this work, we aim to demonstrate increased sensitivity to disease progression as well a
Externí odkaz:
https://doaj.org/article/8d01a7cd74c64ff0a62d0761567995bd
Autor:
Young Woo Park, James M. Joers, Bin Guo, Diane Hutter, Khalaf Bushara, Isaac M. Adanyeguh, Lynn E. Eberly, Gülin Öz, Christophe Lenglet
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/dd2d766503f84188952126c9041e05f3
Autor:
Isaac M. Adanyeguh, Francesca Branzoli, Cécile Delorme, Aurélie Méneret, Marie-Lorraine Monin, Marie-Pierre Luton, Alexandra Durr, Emanoel Sabidussi, Fanny Mochel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Huntington’s disease (HD) is a monogenic, fully penetrant neurodegenerative disorder. Widespread white matter damage affects the brain of patients with HD at very early stages of the disease. Fixel-based analysis (FBA) is a novel method to
Externí odkaz:
https://doaj.org/article/f7abda06509c4ea3a642f325b6131684
Autor:
Nellie Georgiou-Karistianis, Louise A. Corben, Kathrin Reetz, Isaac M. Adanyeguh, Manuela Corti, Dinesh K. Deelchand, Martin B. Delatycki, Imis Dogan, Rebecca Evans, Jennifer Farmer, Marcondes C. França, William Gaetz, Ian H. Harding, Karen S. Harris, Steven Hersch, Richard Joules, James J. Joers, Michelle L. Krishnan, Michelle Lax, Eric F. Lock, David Lynch, Thomas Mareci, Sahan Muthuhetti Gamage, Massimo Pandolfo, Marina Papoutsi, Thiago J. R. Rezende, Timothy P. L. Roberts, Jens T. Rosenberg, Sandro Romanzetti, Jörg B. Schulz, Traci Schilling, Adam J. Schwarz, Sub Subramony, Bert Yao, Stephen Zicha, Christophe Lenglet, Pierre-Gilles Henry
Publikováno v:
PLoS ONE, Vol 17, Iss 11 (2022)
Introduction Drug development for neurodegenerative diseases such as Friedreich’s ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response in affected tissue and disease progression. Studies employing neuroi
Externí odkaz:
https://doaj.org/article/3798d34d306b465d9481db92a4e93617
Autor:
Isaac M. Adanyeguh, Xiaofang Lou, Eavan McGovern, Marie-Pierre Luton, Magali Barbier, Elise Yazbeck, Romain Valabregue, Dinesh Deelchand, Pierre-Gilles Henry, Fanny Mochel
Publikováno v:
NeuroImage: Clinical, Vol 29, Iss , Pp 102566- (2021)
Objective: Progressive myelopathy causes severe handicap in men with adrenomyeloneuropathy (AMN), an X-linked disorder due to ABCD1 pathogenic variants. At present, treatments are symptomatic but disease-modifying therapies are under evaluation. Give
Externí odkaz:
https://doaj.org/article/29c57df5b7a6468f866b5217ee81439f
Autor:
Young Woo Park, James M. Joers, Bin Guo, Diane Hutter, Khalaf Bushara, Isaac M. Adanyeguh, Lynn E. Eberly, Gülin Öz, Christophe Lenglet
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Development of imaging biomarkers for rare neurodegenerative diseases such as spinocerebellar ataxia (SCA) is important to non-invasively track progression of disease pathology and monitor response to interventions. Diffusion MRI (dMRI) has been show
Externí odkaz:
https://doaj.org/article/5f2e34b2b3374ead86b07309bc1fee3d
Autor:
Isaac M. Adanyeguh, Vincent Perlbarg, Pierre-Gilles Henry, Daisy Rinaldi, Elodie Petit, Romain Valabregue, Alexis Brice, Alexandra Durr, Fanny Mochel
Publikováno v:
NeuroImage: Clinical, Vol 19, Iss , Pp 858-867 (2018)
Objective: As gene-based therapies may soon arise for patients with spinocerebellar ataxia (SCA), there is a critical need to identify biomarkers of disease progression with effect sizes greater than clinical scores, enabling trials with smaller samp
Externí odkaz:
https://doaj.org/article/a98f9f436c4249948524b4f7c0ddd367
Autor:
Thiago J.R. Rezende, Isaac M. Adanyeguh, Filippo Arrigoni, Benjamin Bender, Fernando Cendes, Louise A. Corben, Andreas Deistung, Martin Delatycki, Imis Dogan, Gary F. Egan, Sophia L. Göricke, Nellie Georgiou‐Karistianis, Pierre‐Gilles Henry, Diane Hutter, Neda Jahanshad, James M. Joers, Christophe Lenglet, Tobias Lindig, Alberto R.M. Martinez, Andrea Martinuzzi, Gabriella Paparella, Denis Peruzzo, Kathrin Reetz, Sandro Romanzetti, Ludger Schöls, Jörg B. Schulz, Matthis Synofzik, Sophia I. Thomopoulos, Paul M. Thompson, Dagmar Timmann, Ian H. Harding, Marcondes C. França
Publikováno v:
Movement disorders 38(1), 45-56 (2023). doi:10.1002/mds.29261
Movement disorders 38(1), 45-56 (2023). doi:10.1002/mds.29261
Published by Wiley, New York, NY
Published by Wiley, New York, NY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94c22723442e87c30d8388a929792d8
https://pubmed.ncbi.nlm.nih.gov/36308733
https://pubmed.ncbi.nlm.nih.gov/36308733
Autor:
Thiago JR Rezende, Isaac M Adanyeguh, Filippo Arrigoni, Benjamin Bender, Fernando Cendes, Louise A Corben, Andreas Deistung, Martin Delatycki, Imis Dogan, Gary F Egan, Sophia L Göricke, Nellie Georgiou-Karistianis, Pierre-Gilles Henry, Diane Hutter, Neda Jahanshad, James M Joers, Christophe Lenglet, Tobias Lindig, Alberto RM Martinez, Andrea Martinuzzi, Gabriella Paparella, Denis Peruzzo, Kathrin Reetz, Sandro Romanzetti, Ludger Schöls, Jörg B Schulz, Matthis Synofzik, Sophia I Thomopoulos, Paul M Thompson, Dagmar Timmann, Ian H Harding, Marcondes C. França
ObjectiveSpinal cord damage is a hallmark of Friedreich ataxia (FRDA), but its progression and clinical correlates remain unclear. Here we performed a characterization of cervical spinal cord structural abnormalities in a large multisite FRDA cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3726442601dfb55b984094b072ecc4a
https://doi.org/10.1101/2022.04.20.22273878
https://doi.org/10.1101/2022.04.20.22273878
Autor:
James M Joers, Isaac M Adanyeguh, Dinesh K Deelchand, Diane H Hutter, Lynn E Eberly, Isabelle Iltis, Khalaf O Bushara, Christophe Lenglet, Pierre-Gilles Henry
Publikováno v:
Brain communications. 4(5)
Friedreich ataxia is the most common hereditary ataxia. Atrophy of the spinal cord is one of the hallmarks of the disease. MRI and magnetic resonance spectroscopy are powerful and non-invasive tools to investigate pathological changes in the spinal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1831b43883a651c256ec0b8b1ba4ef5
https://pubmed.ncbi.nlm.nih.gov/36300142
https://pubmed.ncbi.nlm.nih.gov/36300142