Zobrazeno 1 - 10 of 71 pro vyhledávání: '"Isaac M Westwood"'
1
Akademický článek
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2.
Autor: M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65689 (2013)
Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift ass
Externí odkaz: https://doaj.org/article/d0694d58cc464620a9a172b566b0062e
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2
Akademický článek
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Autor: Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Isaac M Westwood, Sanjib Bhakta, Alun Christopher Garner, David L Wilson, Peter T Seden, Stephen G Davies, Angela J Russell, Elspeth F Garman, Edith Sim
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52790 (2012)
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection. Catabolism of
Externí odkaz: https://doaj.org/article/98aa6a8b02cc47b2b32db13289c90ae5
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3
Akademický článek
Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70
Autor: Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins
Publikováno v: Molecules, Vol 27, Iss 3, p 817 (2022)
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HS
Externí odkaz: https://doaj.org/article/107fca8fd5c94697bed8fa0f96ed1083
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