Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Isaac K. Nardi"'
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Akademický článek
Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres
Autor: Madison E. Stellfox, Isaac K. Nardi, Christina M. Knippler, Daniel R. Foltz
Publikováno v: Cell Reports, Vol 15, Iss 10, Pp 2127-2135 (2016)
The Mis18 complex specifies the site of new CENP-A nucleosome assembly by recruiting the CENP-A-specific assembly factor HJURP (Holliday junction recognition protein). The human Mis18 complex consists of Mis18α, Mis18β, and Mis18 binding protein 1
Externí odkaz: https://doaj.org/article/3fd70a15e74d42548bb12f63f92c0851
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2
Data from Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma
Autor: Dan J. Raz, Ming Gao, Isaac K. Nardi, Jami Wang, Jun Wu, Melissa Bonner, Lu Yang, Rajendra P. Pangeni, Jinhui Wang, Keqiang Zhang, Xinwei Yun
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated the association and impact of the ubiquitin-specific peptidase 22 (USP22),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::270f56f1a6a43439d331a62a5e8c40a2
https://doi.org/10.1158/1541-7786.c.6541216
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5
Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3
Autor: Jami Wang, Li Zheng, Jae Y. Kim, Theresa A. Reno, Dan J. Raz, Huifang Dai, Binghui Shen, Terra Sztain, Xinwei Yun, Isaac K. Nardi
Publikováno v: International Journal of Cancer. 143:2470-2478
In the last decade, it has become clear that epigenetic changes act together with genetic mutations to promote virtually every stage of tumorigenesis and cancer progression. This knowledge has triggered searches for “epigenetic drugs” that can be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de40ceec82bcbc49a8dfaa4d22cfba02
https://doi.org/10.1002/ijc.31756
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6
Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma
Autor: Isaac K. Nardi, Dan J. Raz, Lu Yang, Jinhui Wang, Jami Wang, Rajendra P. Pangeni, Xinwei Yun, Melissa Bonner, Ming Gao, Keqiang Zhang, Jun Wu
Publikováno v: Molecular Cancer Research. 16:1161-1171
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated the association and impact of the ubiquitin-specific peptidase 22 (USP22),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f43a6f422ebb52a618469ec15ad3e9f
https://doi.org/10.1158/1541-7786.mcr-18-0042
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7
USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks
Autor: Isaac K. Nardi, Jeremy M. Stark, Adrien B. Larsen, Ravi Salgia, Dan J. Raz
Publikováno v: Mol Cancer Res
Homologous recombination (HR) is a highly conserved pathway that can facilitate the repair of DNA double-strand breaks (DSB). Several Deubiquitinases (DUB) have been implicated as key players in DNA damage repair (DDR) through HR. Here, we report USP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021d6870376969f0411f7574230bd6e0
https://pubmed.ncbi.nlm.nih.gov/31685642
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8
Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer
Autor: Isaac K. Nardi, Madison E. Stellfox, Daniel R. Foltz, Christina M. Knippler, Ewelina Zasadzińska
Publikováno v: Molecular Cell. 61(5):774-787
Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872ad6071311e70f35b092be67dd7ddc
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9
Abstract 1750: USP22 directly interacts with PALB2 and is required for efficient homologous recombination of DNA double-strand breaks
Autor: Isaac K. Nardi, Jeremy Stark, Adrien Larsen, Dan Raz
Publikováno v: Cancer Research. 79:1750-1750
DNA damage by environmental stressors and agents is a huge problem for cells and must be repaired quickly for the cell to maintain its integrity. Cells employ several repair pathways and mechanisms to rectify damaged DNA. Homologous Recombination (HR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::576e06f81cb4782a99970b4e85efced9
https://doi.org/10.1158/1538-7445.am2019-1750
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10
Timing of centrosome separation is important for accurate chromosome segregation
Autor: Daniela Cimini, Alex Mogilner, Isaac K. Nardi, William T. Silkworth, Raja Paul
Publikováno v: Molecular Biology of the Cell
Centrosome separation can be completed either before or after nuclear envelope breakdown (NEB). A combination of experimental and computational approaches shows that incomplete centrosome separation at NEB decreases the accuracy of chromosome segrega
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f71cf09b885073122d8e89a856bb8c
https://doi.org/10.1091/mbc.e11-02-0095
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