Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Isaac J Jensen"'
Autor:
Roger R Berton, Patrick W McGonagil, Isaac J Jensen, Tiffany K Ybarra, Gail A Bishop, John T Harty, Thomas S Griffith, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011720 (2023)
Sepsis, an amplified immune response to systemic infection, is characterized by a transient cytokine storm followed by chronic immune dysfunction. Consequently, sepsis survivors are highly susceptible to newly introduced infections, suggesting sepsis
Externí odkaz:
https://doaj.org/article/003cece2a6b74de48c7dbeb1d175f5a5
Autor:
Isaac J Jensen, Xiang Li, Patrick W McGonagill, Qiang Shan, Micaela G Fosdick, Mikaela M Tremblay, Jon CD Houtman, Hai-Hui Xue, Thomas S Griffith, Weiqun Peng, Vladimir P Badovinac
Publikováno v:
eLife, Vol 10 (2021)
The global health burden due to sepsis and the associated cytokine storm is substantial. While early intervention has improved survival during the cytokine storm, those that survive can enter a state of chronic immunoparalysis defined by transient ly
Externí odkaz:
https://doaj.org/article/96b44fa8eb9b49b08945650bd27d9fdc
Autor:
Scott M Anthony, Natalija Van Braeckel-Budimir, Steven J Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M Hartwig, Isaac J Jensen, Steven M Varga, Noah S Butler, Hai-Hui Xue, Vladimir P Badovinac, John T Harty
Publikováno v:
eLife, Vol 10 (2021)
Protective lung tissue-resident memory CD8+T cells (Trm) form after influenza A virus (IAV) infection. We show that IAV infection of mice generates CD69+CD103+and other memory CD8+T cell populations in lung-draining mediastinal lymph nodes (mLNs) fro
Externí odkaz:
https://doaj.org/article/9f4540e8586a46a7b09e4472166aed7e
Autor:
Isaac J Jensen, Samantha N Jensen, Frances V Sjaastad, Katherine N Gibson-Corley, Thamothrampillai Dileepan, Thomas S Griffith, Ashutosh K Mangalam, Vladimir P Badovinac
Publikováno v:
eLife, Vol 9 (2020)
Evaluation of sepsis-induced immunoparalysis has highlighted how decreased lymphocyte number/function contribute to worsened infection/cancer. Yet, an interesting contrast exists with autoimmune disease development, wherein diminishing pathogenic eff
Externí odkaz:
https://doaj.org/article/791eeaac056e44cd9c5088f9d81705e1
Autor:
Isaac J Jensen, Christina S Winborn, Micaela G Fosdick, Peng Shao, Mikaela M Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M Snyder, Hai-Hui Xue, Thomas S Griffith, Jon C Houtman, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007405 (2018)
The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon
Externí odkaz:
https://doaj.org/article/03b923b0ce134deaa8ed4995b5e1b679
Autor:
Derek B Danahy, Scott M Anthony, Isaac J Jensen, Stacey M Hartwig, Qiang Shan, Hai-Hui Xue, John T Harty, Thomas S Griffith, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006569 (2017)
Sepsis is a systemic infection that enhances host vulnerability to secondary infections normally controlled by T cells. Using CLP sepsis model, we observed that sepsis induces apoptosis of circulating memory CD8 T-cells (TCIRCM) and diminishes their
Externí odkaz:
https://doaj.org/article/0dc611150e4242fab88bf6698417c9cc
Autor:
Steven J. Moioffer, Roger R. Berton, Patrick W. McGonagill, Isaac J. Jensen, Thomas S. Griffith, Vladimir P. Badovinac
Publikováno v:
The Journal of Immunology. 210:168-179
Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1°) memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of repeated cognate Ag encounters is largely unknown but important in und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a912befb7277b7c63eb70a07f1ffcaa
https://doi.org/10.4049/jimmunol.2200676
https://doi.org/10.4049/jimmunol.2200676
Publikováno v:
ImmunoHorizons. 6:528-542
Sepsis, an amplified immune response to systemic infection that leads to life-threatening organ dysfunction, affects >125,000 people/day worldwide with 20% mortality. Modest therapeutic progress for sepsis has been made, in part because of the lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12335bdbd81935f712cc73e134f32a1e
https://doi.org/10.4049/immunohorizons.2200050
https://doi.org/10.4049/immunohorizons.2200050
Autor:
Vladimir P. Badovinac, Garry R. Buettner, Isaac J. Jensen, Roger R. Berton, Patrick W. McGonagill, Thomas S. Griffith, Elvia E. Silva, Brett A. Wagner
Publikováno v:
ImmunoHorizons
The dysregulated host response and organ damage following systemic infection that characterizes a septic event predisposes individuals to a chronic immunoparalysis state associated with severe transient lymphopenia and diminished lymphocyte function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a730f790617e1c636bfe0cc2d049a5
https://doi.org/10.4049/immunohorizons.2100027
https://doi.org/10.4049/immunohorizons.2100027
Autor:
Isaac J. Jensen, Vladimir P. Badovinac, Nitin J. Karandikar, Ashley A. Brate, Alexander W. Boyden
Publikováno v:
The Journal of Immunology. 206:1151-1160
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS. We have previously demonstrated that CNS-specific CD8 T cells possess a disease-suppressive function in MS and variations of its animal model, experimental autoimmune enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b94ef81fd455c59b302b2cddadbf5df
https://doi.org/10.4049/jimmunol.2001143
https://doi.org/10.4049/jimmunol.2001143