Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Isaac Goncalves"'
Autor:
David J. Kuter, Merlin Efraim, Jiri Mayer, Marek Trněný, Vickie McDonald, Robert Bird, Thomas Regenbogen, Mamta Garg, Zane Kaplan, Nikolay Tzvetkov, Philip Y. Choi, A.J. Gerard Jansen, Milan Kostal, Ross Baker, Jaromir Gumulec, Eun-Ju Lee, Ilona Cunningham, Isaac Goncalves, Margaret Warner, Ralph Boccia, Terry Gernsheimer, Waleed Ghanima, Olga Bandman, Regan Burns, Ann Neale, Dolca Thomas, Puneet Arora, Beiyao Zheng, Nichola Cooper
Publikováno v:
New England Journal of Medicine, 386(15), 1421-1431. Massachussetts Medical Society
BACKGROUND Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcγ receptor)-mediated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c172dc9093fbc35c4c4cf3aff5170e5c
https://doi.org/10.1056/nejmoa2110297
https://doi.org/10.1056/nejmoa2110297
Autor:
Anoop K Enjeti, Robert Bird, Isaac Goncalves, Chee Wee Tan, Philip Yi Choi, Ashwini Bennett, Danny Hsu, Eileen Merriman
Publikováno v:
Medical Journal of Australia. 216:43-52
Introduction The absence of high quality evidence for basic clinical dilemmas in immune thrombocytopenic purpura (ITP) underlines the need for contemporary guidelines relevant to the local treatment context. ITP is diagnosed by exclusions, with a hal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac2b70a396b44eeb54e1ddb5047dae5
https://doi.org/10.5694/mja2.51284
https://doi.org/10.5694/mja2.51284
Autor:
Saffanah Zahra, Paul S. Myles, Isaac Goncalves, Gryselda Hanafi, Huyen Tran, Anton Ilich, Heidi Ho, Charithani B. Keragala, Nigel S. Key, Dominik F. Draxler, Robert L. Medcalf
Publikováno v:
Blood Coagulation & Fibrinolysis. 32:172-179
Tranexamic acid (TXA) is a lysine analogue that inhibits plasmin generation and has been used for decades as an antifibrinolytic agent to reduce bleeding. Recent reports have indicated that TXA can paradoxically promote plasmin generation. Blood was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8405dd55ca2497a1317f972a0c092e67
https://doi.org/10.1097/mbc.0000000000001008
https://doi.org/10.1097/mbc.0000000000001008
Autor:
Piers Blombery, Michael S Hofman, Grace Kong, Michael Michael, Tim Akhurst, Kate Burbury, Rodney J. Hicks, David Westerman, Ing S. Tiong, Isaac Goncalves, Aravind S. Ravi Kumar, Amir Iravani
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 46:1902-1910
Peptide receptor radionuclide/chemoradionuclide therapy (PRRT/PRCRT) is an effective therapy for metastatic neuroendocrine neoplasia (NEN), but therapy-related myeloid neoplasms (t-MN) remain of concern. The study reviewed the clinicopathological fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce745f0405d3c4daf24046772b36dc
https://doi.org/10.1007/s00259-019-04389-2
https://doi.org/10.1007/s00259-019-04389-2
Autor:
Gryselda Hanafi, Dominik F. Draxler, Kah Yep, Isaac Goncalves, Anoushka Winton, Sophie Wallace, Paul S. Myles, Andrew Forbes, Robert L. Medcalf, Lisa M. Wutzlhofer, Heidi Ho, Maria Daglas, Huyen Tran, Magdalena Plebanski, Maithili Sashindranath
Publikováno v:
Blood advances. 3(10)
Tranexamic acid (TXA) is an antifibrinolytic agent that blocks plasmin formation. Because plasmin is known to promote inflammatory and immunosuppressive responses, we explored the possibility that plasmin-mediated immunosuppression in patients underg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3b6a0f48d182f5a0988f410deb7cc9
https://pubmed.ncbi.nlm.nih.gov/31126915
https://pubmed.ncbi.nlm.nih.gov/31126915
Autor:
Michael S Hofman, Michael Michael, Amir Iravani, Ing S. Tiong, Grace Kong, Kate Burbury, Tim Akhurst, Piers Blombery, Aravind S. Ravi Kumar, Isaac Goncalves, David Westerman, Rodney J. Hicks
Publikováno v:
SSRN Electronic Journal.
Background: Peptide receptor radionuclide/chemoradionuclide therapy(PRRT/PRCRT) is an emerging therapy in patients with metastatic neuroendocrine neoplasia (NEN). However, therapy-related myeloid neoplasms (t-MN) remain a potential complication with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::957676abd1aab0d885ccfb1ef9c881ae
https://doi.org/10.2139/ssrn.3327364
https://doi.org/10.2139/ssrn.3327364
Autor:
Constantine S. Tam, Chloe Pek Sang Tang, Jenny Y. Y. Ooi, Isaac Goncalves, Andre La Gerche, Julie R. McMullen, Sasanka M. Handunnetti, Erin J. Howden
Publikováno v:
Blood. 134:4301-4301
The development of Bruton Kinase Inhibitors (BTKi) has been a major advance in the treatment of chronic lymphocytic leukaemia and related B cell malignancies, but atrial fibrillation (AF) and sudden cardiac deaths are emerging as unique side effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c88185e1df55f9ff470cf353c10048
https://doi.org/10.1182/blood-2019-129808
https://doi.org/10.1182/blood-2019-129808
Autor:
Shaun P. Jackson, Isaac Goncalves, Yuping Yuan, Simone M. Schoenwaelder, Cindy L. Yap, Sascha Claire Hughan
Publikováno v:
Journal of Biological Chemistry. 278:34812-34822
Platelet adhesion to fibrinogen is important for platelet aggregation and thrombus growth. In this study we have examined the mechanisms regulating platelet adhesion on immobilized fibrinogen under static and shear conditions. We demonstrate that int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57aa650ad3e0891247e6299f900c6289
https://doi.org/10.1074/jbc.m306504200
https://doi.org/10.1074/jbc.m306504200
Autor:
François Lanza, Pierre Mangin, Monique Freund, Isaac Goncalves, Anita Eckly, Jean-Pierre Cazenave, Shaun P. Jackson, Yuping Yuan, Christian Gachet
Publikováno v:
Journal of Biological Chemistry. 278:32880-32891
Interaction of the platelet GPIb-V-IX complex with surface immobilized von Willebrand factor (vWf) is required for the capture of circulating platelets and their ensuing activation. In previous work, it was found that GPIb/vWf-mediated platelet adhes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b03715b5a04863dcdfae1abd9d1b83
https://doi.org/10.1074/jbc.m302333200
https://doi.org/10.1074/jbc.m302333200
Autor:
Yuping Yuan, François Lanza, Isaac Goncalves, Shaun P. Jackson, Christine E. Wright, Simone M. Schoenwaelder, Pierre Mangin, C Nonne, Cindy L. Yap, Sharelle Anne Sturgeon
Publikováno v:
Blood. 107(11)
Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRγ-chain complex is a central collagen receptor and inhibitors of GPVI produce a major def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f59341539e60c45026b6dbbe34b05
https://pubmed.ncbi.nlm.nih.gov/16391010
https://pubmed.ncbi.nlm.nih.gov/16391010