Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://doaj.org/article/facd8b78a4874d8e865b236e82696fcb

Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of Rt-PA Administration

Autor: Carme Gubern-Mérida, Elisabet Kádár, Mar Castellanos, María A. Moro, Ignacio Lizasoain, Juan M. Sanchez, Irene Puig-Parnau, Joaquín Serena, Isaac García-Yébenes, Gemma Huguet, Pau Comajoan

Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for acute ischemic stroke. However, its administration is still limited due to the associated increased risk of hemorrhagic transformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437231409bb24f18f1aca74ce81eef77
https://doi.org/10.21203/rs.3.rs-551455/v1

Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke

Autor: Juan González-Hijón, Alicia García-Culebras, David Fernández-López, Violeta Durán-Laforet, Adrián Vega-Pérez, María A. Moro, Ana Moraga, Sara Palma-Tortosa, Isaac García-Yébenes, Ignacio Lizasoain

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience

Tissue perfusion is a necessary condition for vessel survival that can be compromised under ischemic conditions. Following stroke, delayed effects of early brain reperfusion on the vascular substrate necessary for remodelling, perfusion and maintenan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf862fc6cb9b5432214e89b04213271
https://www.frontiersin.org/article/10.3389/fnins.2019.00767/full

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Juan B. Salom, Enrique Alborch, Teresa Gasull, Isaac García-Yébenes, Pedro Ramos-Cabrer, Ignacio Lizasoain, María Castelló-Ruiz, Jovita Ponce, Verónica Guirao, Mónica Millán, José Castillo, Antoni Dávalos, Octavi Martí-Sistac, Nuria DeGregorio-Rocasolano

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Redox Biology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810b789a7d186b24d714a1ffbfc93687
https://ddd.uab.cat/record/190741

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

Autor: Juan de la Parra, Jaime Díaz-Guzmán, Ignacio Lizasoain, Sara Palma-Tortosa, Jesús M. Pradillo, Ana Moraga, Isaac García-Yébenes, María A. Moro, María Isabel Cuartero, Ana L. Barrios-Muñoz, Alicia García-Culebras, Violeta Durán-Laforet

Publikováno v: Stroke. 48(6)

Background and Purpose— Hemorrhagic transformation is the main complication of revascularization therapies after stroke. Toll-like receptor 4 (TLR4) is implicated in cerebral damage and inflammation in stroke. This study was designed to determine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d739c2564e49c872831986bbaa9e9
https://pubmed.ncbi.nlm.nih.gov/28428349