Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Isaac Dripps"'
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Autor:
Zachariah Bertels, Harinder Singh, Isaac Dripps, Kendra Siegersma, Alycia F Tipton, Wiktor D Witkowski, Zoie Sheets, Pal Shah, Catherine Conway, Elizaveta Mangutov, Mei Ao, Valentina Petukhova, Bhargava Karumudi, Pavel A Petukhov, Serapio M Baca, Mark M Rasenick, Amynah A Pradhan
Publikováno v:
eLife, Vol 10 (2021)
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacet
Externí odkaz:
https://doaj.org/article/7606ea99f0624f14a360122dad495479
Autor:
Hyeonsoo Jeong, Laura S. Moye, Bruce R. Southey, Alvaro G. Hernandez, Isaac Dripps, Elena V. Romanova, Stanislav S. Rubakhin, Jonathan V. Sweedler, Amynah A. Pradhan, Sandra L. Rodriguez-Zas
Publikováno v:
Frontiers in Systems Neuroscience, Vol 12 (2018)
The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice. This model has been used to study the neurological disorder of trigeminovascular pain or migraine, a debilitating form of hyperalgesia. The present study valida
Externí odkaz:
https://doaj.org/article/5e19a9dfa45a49dcb6efe4d0c32496d2
Autor:
Elizaveta Mangutov, Isaac Dripps, Kendra Siegersma, Rebecca Bocian, Sarah Asif, Wiktor Witkowski, Amynah Pradhan
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Autor:
Laura S. Moye, Isaac Dripps, Zachariah Bertels, Amynah A. Pradhan, Brigitte L. Kieffer, Kendra Siegersma, Serapio M. Baca, Alycia F Tipton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Delta opioid receptor (DOR) agonists have been identified as a promising novel therapy for headache disorders. DORs are broadly expressed in several peripheral and central regions important for pain processing and mood regulation; and it is unclear w
Autor:
Mohammad Rayhan Sultan Jabir, Lauren C Strother, Philip R. Holland, Amynah A. Pradhan, Chonlawan Saengjaroentham, Peter J. Goadsby, Isaac Dripps
Publikováno v:
Brain
Saengjaroentham, C, Strother, L C, Dripps, I, Sultan Jabir, M R, Pradhan, A, Goadsby, P J & Holland, P R 2020, ' Differential medication overuse risk of novel anti-migraine therapeutics ', Brain, vol. 143, no. 9, pp. 2681-2688 . https://doi.org/10.1093/brain/awaa211
Saengjaroentham, C, Strother, L C, Dripps, I, Sultan Jabir, M R, Pradhan, A, Goadsby, P J & Holland, P R 2020, ' Differential medication overuse risk of novel anti-migraine therapeutics ', Brain, vol. 143, no. 9, pp. 2681-2688 . https://doi.org/10.1093/brain/awaa211
Medication overuse headache is estimated to affect 2% of the population, and is ranked in the top 20 most disabling disorders due to its high level of disability. Several therapies used in the treatment of acute migraine are thought to be associated
Autor:
Philip R. Holland, Lauren C Strother, Christopher Holton, Peter J. Goadsby, Amynah A. Pradhan, Isaac Dripps
Publikováno v:
British Journal of Pharmacology
Background and purpose There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid-sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expresse
Autor:
Stanislav S. Rubakhin, Amynah A. Pradhan, Jonathan V. Sweedler, Elena V. Romanova, Ning Yang, Krishna D. B. Anapindi, Alycia F Tipton, Isaac Dripps, Zoie Sheets
Publikováno v:
Mol Cell Proteomics
Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to treat migraine, these drugs can result in increased pain and headache chronicity. We hypothesized that overlapping mechanisms between OIH and chronic migraine occu
Autor:
Amynah A. Pradhan, Jonathan V. Sweedler, Bruce R. Southey, Pan Zhang, Sandra L. Rodriguez-Zas, Laura S. Moye, Isaac Dripps
Publikováno v:
Mol Neurobiol
The benefits of opioid-based treatments to mitigate chronic pain can be hindered by the side effects of opioid-induced hyperalgesia (OIH) that can lead to higher consumption and risk of addiction. The present study advances the understanding of the m
Autor:
Amynah A. Pradhan, Laura S. Moye, Aimee L. Crombie, Alycia F Tipton, Isaac Dripps, Zoie Sheets, Jonathan D. Violin
Publikováno v:
Neuropharmacology. 148:77-86
Headaches are highly disabling and are among the most common neurological disorders worldwide. Despite the high prevalence of headache, therapeutic options are limited. We recently identified the delta opioid receptor (DOR) as an emerging therapeutic
Autor:
Dong Wang, Wiktor D Witkowski, Grégory Scherrer, Amynah A. Pradhan, Elizaveta Mangutov, Isaac Dripps, Laura S Moye, Kendra Siegersma
Publikováno v:
Pain
Migraine is highly prevalent and is the sixth leading cause worldwide for years lost to disability. Therapeutic options specifically targeting migraine are limited, and delta opioid receptor (DOP) agonists were recently identified as a promising phar