Type-H endothelial cell protein Clec14a orchestrates osteoblast activity during trabecular bone formation and patterning

Autor: Georgiana Neag, Jonathan Lewis, Jason D. Turner, Julia E. Manning, Isaac Dean, Melissa Finlay, Gowsihan Poologasundarampillai, Jonathan Woods, Muhammad Arham Sahu, Kabir A. Khan, Jenefa Begum, Helen M. McGettrick, Ilaria Bellantuono, Victoria Heath, Simon W. Jones, Christopher D. Buckley, Roy Bicknell, Amy J. Naylor

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial ce

Externí odkaz: https://doaj.org/article/85498a388ee845cc9022af51c103ca92

Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity

Autor: Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu

Externí odkaz: https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935

Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner

Autor: Guerman Molostvov, Mariam Gachechiladze, Abeer M. Shaaban, Steven Hayward, Isaac Dean, Irundika H.K. Dias, Nahla Badr, Irini Danial, Fiyaz Mohammed, Vera Novitskaya, Liliia Paniushkina, Valerie Speirs, Andrew Hanby, Irina Nazarenko, David R. Withers, Steven van Laere, Heather M. Long, Fedor Berditchevski

Publikováno v: Cell Reports, Vol 42, Iss 3, Pp 112207- (2023)

Summary: The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment of B lymphocytes to BCa tissues is controlled via mechanisms associated with ca

Externí odkaz: https://doaj.org/article/d52dec9b7f7b4b208e542f1913acb799

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

Autor: Joanne E. Anstee, James W. Opzoomer, Isaac Dean, Henrike P. Muller, Meriem Bahri, Kifayathullah Liakath-Ali, Ziyan Liu, Desmond Choy, Jonathan Caron, Dominika Sosnowska, Richard Beatson, Tamara Muliaditan, Zhengwen An, Cheryl E. Gillett, Guocheng Lan, Xiangang Zou, Fiona M. Watt, Tony Ng, Joy M. Burchell, Shahram Kordasti, David R. Withers, Toby Lawrence, James N. Arnold

A subset of tumor associated macrophages (TAMs) identified by their expression of the lymphatic vessel endothelial hyaluronan receptor-1 (Lyve-1) reside proximal to blood vasculature and contribute to disease progression. Using a spontaneous murine m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6d5f73dcd9eeaa3e785bd95845db1cf
https://doi.org/10.1101/2022.02.03.478952

Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

Autor: Dominika Sosnowska, Joanne E. Anstee, Shahram Kordasti, Tamara Muliaditan, Francesco Dazzi, Tony Ng, Emily J. Hill, James N. Arnold, Jonathan Caron, Ihssane Bouybayoune, James W. Opzoomer, Toby Lawrence, Isaac Dean, Sarah E Pinder, Patrick Gordon, Rosamond Nuamah, David R. Withers

Publikováno v: Science Advances
Science Advances, 2021, 7 (45), ⟨10.1126/sciadv.abg9518⟩
Science advances, 7(45), 1. American Association for the Advancement of Science

Description
Perivascular macrophages orchestrate the expansion of pericyte-like mesenchymal cells to create a proangiogenic niche in cancer.
Tumor-associated macrophages (TAMs) are a highly plastic stromal cell type that support cancer prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de8878cb3d904ebd4978a3f80d1353
https://doi.org/10.1101/2020.10.30.361907