Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Isaac D. Lutz"'
Autor:
Isaac D. Lutz, Shunzhi Wang, Christoffer Norn, Alexis Courbet, Andrew J. Borst, Yan Ting Zhao, Annie Dosey, Longxing Cao, Jinwei Xu, Elizabeth M. Leaf, Catherine Treichel, Patrisia Litvicov, Zhe Li, Alexander D. Goodson, Paula Rivera-Sánchez, Ana-Maria Bratovianu, Minkyung Baek, Neil P. King, Hannele Ruohola-Baker, David Baker
Publikováno v:
Science. 380:266-273
As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d6aae353691a14e38e1bdc446a8251
https://doi.org/10.1126/science.adf6591
https://doi.org/10.1126/science.adf6591
Autor:
Susana Vázquez Torres, Philip J. Y. Leung, Isaac D. Lutz, Preetham Venkatesh, Joseph L. Watson, Fabian Hink, Huu-Hien Huynh, Andy Hsien-Wei Yeh, David Juergens, Nathaniel R. Bennett, Andrew N. Hoofnagle, Eric Huang, Michael J MacCoss, Marc Expòsit, Gyu Rie Lee, Paul M. Levine, Xinting Li, Mila Lamb, Elif Nihal Korkmaz, Jeff Nivala, Lance Stewart, Joseph M. Rogers, David Baker
Many peptide hormones form an alpha-helix upon binding their receptors1–4, and sensitive detection methods for them could contribute to better clinical management.De novoprotein design can now generate binders with high affinity and specificity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f71e8af52449b591ee281d1a65d41b
https://doi.org/10.1101/2022.12.10.519862
https://doi.org/10.1101/2022.12.10.519862
Autor:
Isaac D. Lutz, Shunzhi Wang, Christoffer Norn, Andrew J. Borst, Yan Ting Zhao, Annie Dosey, Longxing Cao, Zhe Li, Minkyung Baek, Neil P. King, Hannele Ruohola-Baker, David Baker
The multisubunit protein assemblies that play critical roles in biology are the result of evolutionary selection for function of the entire assembly, and hence the subunits in structures such as icosahedral viral capsids often fit together with remar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4d402d360baee06cf37328a1fb2e4c
https://doi.org/10.1101/2022.09.25.509419
https://doi.org/10.1101/2022.09.25.509419
Autor:
Felix B. Pedersen, Stan Wang, Marc J. Lajoie, Verena Volf, Xavier Rios, Timothy M. Wannier, Anik Debnath, John Aach, Michael T. Laub, Devon A. Stork, Isaac D. Lutz, Gabriel T. Filsinger, Julie Zhang, Kevin Gozzi, Christopher J. Gregg, Seth L. Shipman, George M. Church, Helene M. Kuchwara
Publikováno v:
Filsinger, G T, Wannier, T M, Pedersen, F B, Lutz, I D, Zhang, J, Stork, D A, Debnath, A, Gozzi, K, Kuchwara, H, Volf, V, Wang, S, Rios, X, Gregg, C J, Lajoie, M J, Shipman, S L, Aach, J, Laub, M T & Church, G M 2021, ' Characterizing the portability of phage-encoded homologous recombination proteins ', Nature Chemical Biology, vol. 17, no. 4, pp. 394-402 . https://doi.org/10.1038/s41589-020-00710-5
Nature chemical biology
Nature chemical biology
Efficient genome editing methods are essential for biotechnology and fundamental research. Homologous recombination (HR) is the most versatile method of genome editing, but techniques that rely on host RecA-mediated pathways are inefficient and labor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce71405ae8898e68bc616a0a56a0d02
https://portal.findresearcher.sdu.dk/da/publications/a434af18-9d3d-4fe9-be6d-13d7c0ffd667
https://portal.findresearcher.sdu.dk/da/publications/a434af18-9d3d-4fe9-be6d-13d7c0ffd667
Autor:
Stan Wang, Anik Debnath, Marc J. Lajoie, Michael T. Laub, George M. Church, Helene M. Kuchwara, Verena Volf, Gabriel T. Filsinger, Julie Zhang, Kevin Gozzi, Christopher J. Gregg, Timothy M. Wannier, Felix B. Pedersen, John Aach, Devon A. Stork, Seth L. Shipman, Xavier Rios, Isaac D. Lutz
Bacterial genome editing methods are used to engineer strains for biotechnology and fundamental research. Homologous recombination (HR) is the most versatile method of genome editing, but traditional techniques using endogenous RecA-mediated pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fd0788133d9c4a0b73a158a203d7c7
Autor:
Aaron P. Smith, Juliane Totzke, David R. Loiselle, David A. Alcorta, Lauren B. Crowe, Takuya Osada, Debasish Roy, Timothy A.J. Haystead, Philip F. Hughes, H. Kim Lyerly, Madhusudhana Gargesha, Neil L. Spector, David B. Darr, Isaac D. Lutz, Jose R. Roques
Publikováno v:
ACS chemical biology. 12(4)
Extracellular expression of heat shock protein 90 (eHsp90) by tumor cells is correlated with malignancy. Development of small molecule probes that can detect eHsp90 in vivo may therefore have utility in the early detection of malignancy. We synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1447d705883c96039fbb142349c14447
https://pubmed.ncbi.nlm.nih.gov/28103010
https://pubmed.ncbi.nlm.nih.gov/28103010