Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Isaac B Hilton"'
Autor:
Michael A. Beauregard, Guy C. Bedford, Daniel A. Brenner, Leonardo D. Sanchez Solis, Tomoki Nishiguchi, Abhimanyu, Santiago Carrero Longlax, Barun Mahata, Omid Veiseh, Pamela L. Wenzel, Andrew R. DiNardo, Isaac B. Hilton, Michael R. Diehl
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101316- (2024)
Mesenchymal stem/stromal cells (MSCs) are an attractive platform for cell therapy due to their safety profile and unique ability to secrete broad arrays of immunomodulatory and regenerative molecules. Yet, MSCs are well known to require preconditioni
Externí odkaz:
https://doaj.org/article/e86d582bc7b24da68aaf3797d4526f33
Autor:
Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 1-13 (2024)
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistica
Externí odkaz:
https://doaj.org/article/99aa19c8944b4368939a87375caa3abd
Autor:
Jing Li, Barun Mahata, Mario Escobar, Jacob Goell, Kaiyuan Wang, Pranav Khemka, Isaac B. Hilton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Histone phosphorylation is a ubiquitous post-translational modification. Here the authors present a programmable chromatin kinase, dCas9-dMSK1, that enables controlled histone phosphorylation and specific gene activation.
Externí odkaz:
https://doaj.org/article/6d21162ee2d44cb2a82ad45c7417447d
Autor:
Abhimanyu, Carlos O. Ontiveros, Rosa S. Guerra-Resendez, Tomoki Nishiguchi, Malik Ladki, Isaac B. Hilton, Larry S. Schlesinger, Andrew R. DiNardo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immune response must balance the pro-inflammatory, cell-mediated cytotoxicity with the anti-inflammatory and wound repair response. Epigenetic mechanisms mediate this balance and limit host immunity from inducing exuberant collateral damage to ho
Externí odkaz:
https://doaj.org/article/45e85e924f9443939c74f537a7a50d89
Autor:
Fanglong Zhao, Chunxiao Sun, Zhiwen Liu, Alan Cabrera, Mario Escobar, Shunyu Huang, Qichen Yuan, Qiuyue Nie, Kevin Lee Luo, Angela Lin, Jeffrey A. Vanegas, Tong Zhu, Isaac B. Hilton, Xue Gao
Publikováno v:
J Am Chem Soc
Genome mining of cryptic natural products (NPs) remains challenging, especially in filamentous fungi, owing to their complex genetic regulation. Increasing evidence indicates that several epigenetic modifications often act cooperatively to control fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df537ccc8b71f71f95ae1abaed30b989
https://doi.org/10.1021/jacs.2c10211
https://doi.org/10.1021/jacs.2c10211
Publikováno v:
Molecular Therapy. 30:3512-3514
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643a4f4e194027f5aaffbab300220d2c
https://doi.org/10.1016/j.ymthe.2022.10.003
https://doi.org/10.1016/j.ymthe.2022.10.003
Autor:
Kaiyuan Wang, Mario Escobar, Jing Li, Barun Mahata, Jacob Goell, Spencer Shah, Madeleine Cluck, Isaac B Hilton
Publikováno v:
Nucleic Acids Research. 50:7842-7855
Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb27d36483fb03164e1bb489d6392aa
https://doi.org/10.1093/nar/gkac582
https://doi.org/10.1093/nar/gkac582
Autor:
Dirk P. Dittmer, Blossom Damania, Kristen M. Tamburro, Isaac B. Hilton, Veenadhari Chavakula, Anthony Eason, Ling Wang, Raman Venkataramanan, Amy Lucas, Sang-Hoon Sin, Debasmita Roy
PDF file - 41K, Suppl. Figure 1: Inhibition of VEGF secretion of PEL cells by rapamycin as measured by ELISA and bioassay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d445ca4d72d3d2184a191dd1074b74f
https://doi.org/10.1158/0008-5472.22398722
https://doi.org/10.1158/0008-5472.22398722
Autor:
Dirk P. Dittmer, Blossom Damania, Kristen M. Tamburro, Isaac B. Hilton, Veenadhari Chavakula, Anthony Eason, Ling Wang, Raman Venkataramanan, Amy Lucas, Sang-Hoon Sin, Debasmita Roy
PDF file - 84K, Suppl. Figure 2: Apoptosis induction of PEL cells by combination of rapamycin and doxorubicin in culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db17e29ca6896ef07d52cdf79da3b73
https://doi.org/10.1158/0008-5472.22398719.v1
https://doi.org/10.1158/0008-5472.22398719.v1
Autor:
Dirk P. Dittmer, Blossom Damania, Kristen M. Tamburro, Isaac B. Hilton, Veenadhari Chavakula, Anthony Eason, Ling Wang, Raman Venkataramanan, Amy Lucas, Sang-Hoon Sin, Debasmita Roy
PDF file - 73K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f8c703388f6afd10bea103b47cb39f
https://doi.org/10.1158/0008-5472.22398713
https://doi.org/10.1158/0008-5472.22398713