Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Isaac, Bai"'
Autor:
Isaac Bai, Cameron Keyser, Ziyan Zhang, Breandan Rosolia, Jee-Yeon Hwang, R. Suzanne Zukin, Jingqi Yan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Autophagy is a conserved cellular mechanism that enables the degradation and recycling of cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and maintenance of neuronal homeostasis, autophagy is required to regulate presy
Externí odkaz:
https://doaj.org/article/d94128eb929f472b8d142513d2f9c454
Autor:
Marine Jary, Wen‐Wei Liu, Dongyao Yan, Isaac Bai, Andrea Muranyi, Elise Colle, Isabelle Brocheriou, Anthony Turpin, Nina Radosevic‐Robin, Pierre Bourgoin, Frédérique Penault‐Llorca, Romain Cohen, Dewi Vernerey, Thierry André, Christophe Borg, Kandavel Shanmugam, Magali Svrcek
Publikováno v:
Molecular Oncology, Vol 16, Iss 11, Pp 2260-2273 (2022)
In the era of immune checkpoint inhibitors, understanding the metastatic microenvironment of proficient mismatch repair/microsatellite stable (pMMR/MSS) colorectal cancer (CRC) is of paramount importance to both prognostication and the development of
Externí odkaz:
https://doaj.org/article/528753a036b940b0a01d68a276c317a4
Autor:
Isaac Bai, Olga Kits, Sarah Burgess, Anne Marie Whelan, Emily Reeve, Jennifer E. Isenor, Natalie Kennie-Kaulbach, Sarah Kehoe
Publikováno v:
Evidence & Policy. 18:619-630
Background:Deprescribing, the process of dose reduction or stopping of medication(s) that may no longer be required, may improve medication use and patient outcomes. A collaborative interprofessional deprescribing research team was formed in 2017 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f458b74516f018af561a0d0d06e2a956
https://doi.org/10.1332/174426421x16141831484350
https://doi.org/10.1332/174426421x16141831484350
Autor:
Kandavel Shanmugam, Philip Quirke, Matthew T. Seymour, Isaac Bai, Michael Barnes, Jennifer H. Barrett, Nicholas P. West, Dongyao Yan, Wen-Wei Liu, Kien Nguyen, Xingwei Wang, Jim Martin, Zuo Zhao, Uday Kurkure, Auranuch Lorsakul, Christoph Guetter, Andrea Muranyi, Xiao-Meng Xu, Judith Pugh, Shalini Singh, Liping Zhang, Sarah Brown, Susan D. Richman, Michael Shires, Faye Elliott, Jenny F. Seligmann, Christopher J.M. Williams
Table S1: Baseline patient demographics and disease characteristics. Table S2: mRNA/IHC AREG/EREG concordance table. Figure S1: AREG/EREG IHC scatterplot. Table S3: Prognostic effect of dichotomous AREG/EREG. Table S4: AREG/EREG and RECIST response r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d26093065ca47cac56c3fafb14b7ba6
https://doi.org/10.1158/1078-0432.22478486.v1
https://doi.org/10.1158/1078-0432.22478486.v1
Autor:
Kandavel Shanmugam, Philip Quirke, Matthew T. Seymour, Isaac Bai, Michael Barnes, Jennifer H. Barrett, Nicholas P. West, Dongyao Yan, Wen-Wei Liu, Kien Nguyen, Xingwei Wang, Jim Martin, Zuo Zhao, Uday Kurkure, Auranuch Lorsakul, Christoph Guetter, Andrea Muranyi, Xiao-Meng Xu, Judith Pugh, Shalini Singh, Liping Zhang, Sarah Brown, Susan D. Richman, Michael Shires, Faye Elliott, Jenny F. Seligmann, Christopher J.M. Williams
Purpose:High tumor mRNA levels of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG) are associated with anti-EGFR agent response in metastatic colorectal cancer (mCRC). However, ligand RNA assays have not been adopted into routine practice d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3918d1658590fe73e85875c77ed53656
https://doi.org/10.1158/1078-0432.c.6529961
https://doi.org/10.1158/1078-0432.c.6529961
Autor:
Anne Marie Whelan, Jennifer E. Isenor, Ruth Martin-Misener, Natalie Kennie-Kaulbach, Emily Reeve, Melissa Helwig, Isaac Bai, Rachel Cormier, Sarah Burgess
Publikováno v:
Research in Social and Administrative Pharmacy. 17:1229-1241
Background: Polypharmacy and inappropriate medication use are an increasing concern. Deprescribing may improve medication use through planned and supervised dose reduction or stopping of medications. As most medication management occurs in primary he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a8c9ed61bbb2d9c9c46e292ddaf1b
https://doi.org/10.1016/j.sapharm.2020.09.005
https://doi.org/10.1016/j.sapharm.2020.09.005
Autor:
Auranuch Lorsakul, Andrea Muranyi, Uday Kurkure, Kien Nguyen, Wen-Wei Liu, Isaac Bai, Jennifer H. Barrett, Christoph Guetter, Kandavel Shanmugam, Matthew T. Seymour, Philip Quirke, Michael Barnes, Dongyao Yan, Jenny F. Seligmann, Susan D. Richman, Zuo Zhao, Nicholas P. West, Xiao-Meng Xu, Xingwei Wang, Liping Zhang, James R. Martin, Faye Elliott, Michael Shires, Christopher J.M. Williams, Sarah Brown, Judith Pugh, Shalini Singh
Publikováno v:
Clinical Cancer Research. 27:3422-3431
Purpose: High tumor mRNA levels of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG) are associated with anti-EGFR agent response in metastatic colorectal cancer (mCRC). However, ligand RNA assays have not been adopted into routine practice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6101746c3c8a8ca70174ed4fdbc9e5e5
https://doi.org/10.1158/1078-0432.ccr-21-0120
https://doi.org/10.1158/1078-0432.ccr-21-0120
Autor:
Thiago Vidotto, Isaac Bai, Jeffrey J. Tosoian, Dongyao Yan, Daniela C. Salles, Shalini Singh, Andrea Muranyi, Tamara L. Lotan, Farzana A. Faisal, Liana B. Guedes, Kandavel Shanmugam
Publikováno v:
The Journal of Molecular Diagnostics : JMD
This study leveraged a gene-protein assay to assess MYC and PTEN status at prostate cancer biopsy and examined the association with adverse outcomes after surgery. MYC gain and PTEN loss were simultaneously assessed by chromogenic in situ hybridizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510df7eea1fd5044e72dd38de063330b
http://europepmc.org/articles/PMC8491088
http://europepmc.org/articles/PMC8491088
Autor:
Christopher Williams, Faye Elliott, Mike Shires, Henry Wood, Liping Zhang, Zuo Zhao, Isaac Bai, Dongyao Yan, Faranak Aghaei, Uday Kurkure, Chris Bacon, Sarah E Coupland, Simon Cross, D Chas Mangham, Abhik Mukherjee, Jenny F. Seligmann, Nicholas West, Shalini Singh, Kandavel Shanmugam, Philip Quirke
Publikováno v:
Journal of Clinical Oncology. 41:203-203
203 Background: AREG and EREG are ligands of EGFR. AI assisted IHC evaluation of tumor AREG/EREG expression predicted benefit from anti-EGFR therapy in a retrospective analysis of the PICCOLO trial of second-line irinotecan ± panitumumab. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ec8ab3762063772c642cfdea6c777f
https://doi.org/10.1200/jco.2023.41.4_suppl.203
https://doi.org/10.1200/jco.2023.41.4_suppl.203
Autor:
Christopher Williams, Richard G Gray, Mike Shires, Liping Zhang, Zuo Zhao, Isaac Bai, Dongyao Yan, Sarah Dance, Faranak Aghaei, Gemma Hemmings, Michael Hale, Uday Kurkure, Christoph Guetter, Susan D Richman, Gordon Hutchins, Jenny F. Seligmann, Nicholas West, Shalini Singh, Kandavel Shanmugam, Philip Quirke
Publikováno v:
Journal of Clinical Oncology. 41:204-204
204 Background: High CD3+ (all) and CD8+ (cytotoxic) T cell densities in the core (CT) and invasive margin (IM) of primary CRCs have been shown to be associated with superior prognosis at all stages of disease. Their predictive effect on benefit from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed81e496b1d3dcc1df3193ed65631b1b
https://doi.org/10.1200/jco.2023.41.4_suppl.204
https://doi.org/10.1200/jco.2023.41.4_suppl.204