Výsledky vyhledávání - "Iryna Teobald"

Extra-helical binding site of a glucagon receptor antagonist

Autor: Robert M. Cooke, Nathan Robertson, Markus Koglin, Harini Krishnamurthy, Ali Jazayeri, Asma H. Baig, Andrea Bortolato, Malcolm Peter Weir, A.S. Dore, Stacey M. Southall, Fiona H. Marshall, Iryna Teobald, Alastair J. H. Brown, Daniel Lamb, James C. Errey, Stephen P. Andrews

Publikováno v: Nature. 533:274-277

Glucagon is a 29-amino-acid peptide released from the α-cells of the islet of Langerhans, which has a key role in glucose homeostasis. Glucagon action is transduced by the class B G-protein-coupled glucagon receptor (GCGR), which is located on liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a9ef53744660b9de7e12ad85e789ab
https://doi.org/10.1038/nature17414

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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:126611

A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2bdabc56cf80d85af953bc302e66f6
https://doi.org/10.1016/j.bmcl.2019.08.015

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In vitro evaluation of human hybrid cell lines generated by fusion of B-lymphoblastoid cells and ex vivo tumour cells as candidate vaccines for haematological malignancies

Autor: Debbie Dunnion, Yehia S. Mohamed, Michael J. Browning, Iryna Teobald, Renata Walewska

Publikováno v: Vaccine. 30:6578-6587

Fusions of dendritic cells (DCs) and tumour cells have been shown to induce protective immunity to tumour challenge in animal models, and to represent a promising approach to cancer immunotherapy. The broader clinical application of this approach, ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cd8a5d1e3e9cb00b27d5cd6fae767b
https://doi.org/10.1016/j.vaccine.2012.08.032

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Long-lived fusions of human haematological tumour cells and B-lymphoblastoid cells induce tumour antigen-specific cytotoxic T-cell responses in vitro

Autor: Michael J. Browning, Debbie Dunnion, Yehia S. Mohamed, Iryna Teobald, Renata Walewska

Publikováno v: Immunobiology. 217:719-729

Tumour-specific cytotoxic T-cells (CTL) are important anti-cancer immune effectors. Most tumour cells, however, do not stimulate effective anti-tumour immune responses, in vivo or in vitro. To enhance tumour cell immunogenicity, we fused human tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2a9a1f5aeb24c225177af9f5677731
https://doi.org/10.1016/j.imbio.2011.12.001

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Phenotypic and functional differentiation of KG-1 into dendritic-like cells

Autor: M Whitbread, Iryna Teobald, Stephen Curnow, Debbie Dunnion, Michael J. Browning

Publikováno v: Immunobiology. 213:75-86

The cell line KG-1 has been used as an in vitro model for human dendritic cell (DC) differentiation. We have investigated the response of KG-1 cells to stimulation with a number of factors known to induce differentiation and/or maturation of DCs in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8e597013e3abd25a1ebefdb5dedb32
https://doi.org/10.1016/j.imbio.2007.06.001

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Hybrid cells formed by fusion of Epstein - Barr virus-associated B-lymphoblastoid cells and either marrow-derived or solid tumour-derived cell lines display different co-stimulatory phenotypes and abilities to activate allogeneic T-cell responses in vitro

Autor: Debbie Dunnion, Michael J. Browning, A. L. Cywinski, Valerie C. Tucker, Iryna Teobald

Publikováno v: Tissue Antigens. 68:115-126

A panel of stable cell hybrids was generated by fusing a range of marrow-derived and solid tumour-derived human cell lines with the B-lymphoblastoid cell lines, HMy2 or KR4, and expression of immunologically relevant accessory and co-stimulatory mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc77d48d8f545f7133522b803758f0e4
https://doi.org/10.1111/j.1399-0039.2006.00623.x

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Erratum: Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist

Autor: Fiona H. Marshall, Iryna Teobald, Miles Congreve, Jonathan S. Mason, Mathieu Rappas, Alastair J. H. Brown, Robert M. Cooke, James Kean, Malcolm Peter Weir, Andrew S. Doré, Andrea Bortolato, Asma H. Baig, Stephen P. Andrews, James C. Errey, Ali Jazayeri, Cédric Fiez-Vandal, Nathan Robertson

Publikováno v: Nature. 548:122-122

Nature 546, 254–258 (2017); doi:10.1038/nature22800 In the Supplementary Information of this Article, on pages 3, 8 and 11, we refer to “UK Patent Application No. 1522431.4”, which pertains to the discovery of the truncated peptide analogues we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73e3143b28fac31d5ff670aa86c8ba51
https://doi.org/10.1038/nature23311

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Preclinical development of hybrid cell vaccines for multiple myeloma

Autor: Claire Chapman, Micheala A. Aldred, Debbie Dunnion, Iryna Teobald, Jean Sadler, Michael J. Browning, Hind Abdulmajed, Renata Walewska

Publikováno v: European journal of haematology. 78(1)

Immunotherapy may provide alternative or supplementary treatment of multiple myeloma (MM). We propose that hybrid cells, formed by fusing professional antigen-presenting cells with malignant plasma cells, would induce immune responses capable of medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367f4d0911939c2390f29be69acd69ae
https://pubmed.ncbi.nlm.nih.gov/17302859

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