Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Iryna Pishel"'
Autor:
Iryna Pishel
Publikováno v:
Exploration of Immunology, Vol 3, Iss 4, Pp 325-340 (2023)
Interest in the mechanisms of aging of the immune system has not faded over the past 100 years, and it is caused by the immune-mediated development of age-related pathology, including autoimmune organ damage, reduced vaccination efficiency, atheroscl
Externí odkaz:
https://doaj.org/article/e7b13fa87acb4dfeb0814dc29391f111
Autor:
Alexander Kirichok, Hennadii Tkachuk, Yevhenii Kozyriev, Oleh Shablykin, Oleksandr Datsenko, Dmitry Granat, Tetyana Yegorova, Yuliya Bas, Vitalii Semirenko, Iryna Pishel, Vladimir Kubyshkin, Dmytro Lesyk, Oleksii Klymenko-Ulianov, Pavel Mykhailiuk
1-Azaspiro[3.3]heptanes were synthesized, characterized, and validated biologically in vivo as a new generation of saturated piperidine bioisosteres.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3745d850eef7d231f1707e9cff0b2b
https://doi.org/10.26434/chemrxiv-2023-rpjld
https://doi.org/10.26434/chemrxiv-2023-rpjld
Publikováno v:
Rejuvenation Research. 24:345-353
Several studies claimed C60 fullerenes as a prospective geroprotector drug due to their ability to capture free radicals effectively and caused a profound interest in C60 in life extension communit...
Autor:
Halyna Kuznietsova, Petro Borysko, Alexander Rudnichenko, Dmytro L. Titikaiev, Serhii I. Sirobaba, Maksym V. Stambirskyi, Yurii V. Dmytriv, Iryna Pishel, Pavel K. Mykhailiuk, Tetiana Kostiuk
Publikováno v:
The Journal of Organic Chemistry. 86:12783-12801
A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to
Publikováno v:
Rejuvenation research. 25(4)
Our previous study showed that an exchange of blood between heterochronic parabionts for 3 months did not rejuvenate the immune system of the old partners. Moreover, the young immune system became more aged and began to function according to the "old
Autor:
Maksym V, Stambirskyi, Tetiana, Kostiuk, Serhii I, Sirobaba, Alexander, Rudnichenko, Dmytro L, Titikaiev, Yurii V, Dmytriv, Halyna, Kuznietsova, Iryna, Pishel, Petro, Borysko, Pavel K, Mykhailiuk
Publikováno v:
The Journal of organic chemistry. 86(18)
A general practical approach to hetero(aromatic) and aliphatic P(O)Me
Autor:
Dmytro, Shytikov, Iryna, Shytikova, Deepak, Rohila, Anton, Kulaga, Tatiana, Dubiley, Iryna, Pishel
Publikováno v:
Rejuvenation research. 24(5)
Several studies claimed C
Autor:
Nariman F. Salakhutdinov, Sergey Zozulya, Oleksandra Onopchenko, Iryna Pishel, Olga A. Luzina, Maxim Gureev, Mikhail Krasavin, Sergey Kuranov
Publikováno v:
Bioorganic chemistry. 99
Six derivatives of 3-phenylpropionic acid bearing various natural and natural-like, spatially defined peripheral motifs have been synthesized and evaluated in vitro for free fatty acid receptor 1 (FFA1) activation. Two frontrunner compounds (bearing
Publikováno v:
Angewandte Chemie. 129:8991-8995
The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their vali
Autor:
Iryna Pishel, L. V. Yanytska, K. O. Dyakun, I. B. Pryvrotska, T. M. Kuchmerovska, I. Ya. Krynytska, M. M. Guzyk
Publikováno v:
Neurophysiology. 49:183-193
The effects of 1,5-isoquinolinediol (IQD) and nicotinamide (NAm), inhibitors of poly-(ADP-ribose) polymerase-1 (PARP-1), on inflammatory processes and activation of PARP-1 under conditions of the development of experimental diabetic neuropathy, DN (a