Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Iryna M. Ethell"'
Autor:
Karo Talvio, Victoria A. Wagner, Rimante Minkeviciene, Jay S. Kirkwood, Anna O. Kulinich, Juzoh Umemori, Anil Bhatia, Manhoi Hur, Reijo Käkelä, Iryna M. Ethell, Maija L. Castrén
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons.
Externí odkaz:
https://doaj.org/article/2966caa23c6f430e8da00c2f5e4dd530
Autor:
Lauren E. Ethridge, Benjamin D. Auerbach, Anis Contractor, Iryna M. Ethell, Elizabeth A. McCullagh, Ernest V. Pedapati
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/6efb096d9180487a91d9ced5f87931db
Autor:
Pedro A. Villa, Nancy M. Lainez, Carrie R. Jonak, Sarah C. Berlin, Iryna M. Ethell, Djurdjica Coss
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionMutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene cause Fragile X Syndrome, the most common monogenic cause of intellectual disability. Mutations of FMR1 are also associated with reproductive disorders, such as early ce
Externí odkaz:
https://doaj.org/article/4b5de4b1ccc44dbea11ee42ac31830de
Autor:
Patricia S. Pirbhoy, Carrie R. Jonak, Rashid Syed, Donovan A. Argueta, Pedro A. Perez, Mark B. Wiley, Keon Hessamian, Jonathan W. Lovelace, Khaleel A. Razak, Nicholas V. DiPatrizio, Iryna M. Ethell, Devin K. Binder
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background Individuals with Fragile X syndrome (FXS) and autism spectrum disorder (ASD) exhibit an array of symptoms, including sociability deficits, increased anxiety, hyperactivity, and sensory hyperexcitability. It is unclear how endocann
Externí odkaz:
https://doaj.org/article/01f84f04ae0b44e19a2193954cf12657
Autor:
Cassandra Dennys, Carlo Baggio, Rochelle Rodrigo, Florence Roussel, Anna Kulinich, Sarah Heintzman, Ashley Fox, Stephen J. Kolb, Pamela J. Shaw, Iryna M. Ethell, Maurizio Pellecchia, Kathrin C. Meyer
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104877- (2022)
Summary: Amyotrophic lateral sclerosis (ALS) is a degenerative disease that progressively destroys motor neurons (MNs). Earlier studies identified EphA4, a receptor tyrosine kinase, as a possible disease-modifying gene. The complex interplay between
Externí odkaz:
https://doaj.org/article/c75409ffbf4b47f2838cf9114ed20af6
Autor:
Maham Rais, Jonathan W. Lovelace, Xinghao S. Shuai, Walker Woodard, Steven Bishay, Leo Estrada, Ashwin R. Sharma, Austin Nguy, Anna Kulinich, Patricia S. Pirbhoy, Arnold R. Palacios, David L. Nelson, Khaleel A. Razak, Iryna M. Ethell
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105577- (2022)
Background: Fragile X syndrome (FXS) is a leading genetic cause of autism and intellectual disability with cortical hyperexcitability and sensory hypersensitivity attributed to loss and hypofunction of inhibitory parvalbumin-expressing (PV) cells. Ou
Externí odkaz:
https://doaj.org/article/59d4773c4e2a47b0bd3f51d0b57d3dd3
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
The mechanisms underlying the common association between autism spectrum disorders (ASD) and sensory processing disorders (SPD) are unclear, and treatment options to reduce atypical sensory processing are limited. Fragile X Syndrome (FXS) is a leadin
Externí odkaz:
https://doaj.org/article/e53b0f51c115468ca4ef5a041713ca21
Minocycline Treatment Reverses Sound Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability. Many symptoms of FXS overlap with those in autism including repetitive behaviors, language delays, anxiety, social impairments and sensory processing deficits. Elec
Externí odkaz:
https://doaj.org/article/8d270ad9337949bcb61292f5f8fb02fc
Publikováno v:
Neurobiology of Disease, Vol 138, Iss , Pp 104794- (2020)
Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability with symptoms that include increased anxiety and social and sensory processing deficits. Recent EEG studies in humans with FXS have identified neural oscillation def
Externí odkaz:
https://doaj.org/article/bbf1b4ed1a434892b1ca9a1472b5a2e7
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
Astrocytes play a fundamental role in synapse formation, pruning, and plasticity, which are associated with learning and memory. However, the role of astrocytes in learning and memory is still largely unknown. Our previous study showed that astrocyte
Externí odkaz:
https://doaj.org/article/60e7758a5edf498d9221d63d317ffb76