Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Iryna A, Khasabova"'
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Aims Bone cancer produces severe pain that is treated with opioids, but serious side effects limit opioid utilization. There is therefore a need to develop effective and safe non‐opioid alternatives. The lipid mediator, Resolvin D1 (RvD1),
Externí odkaz:
https://doaj.org/article/20826b38ba244904b817eaa151787986
Autor:
Iryna A. Khasabova, Jacob Gable, Malcolm Johns, Sergey G. Khasabov, Alexander E. Kalyuzhny, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, Virginia S. Seybold, Donald A. Simone
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches. Humanized transgenic mouse models have been inst
Externí odkaz:
https://doaj.org/article/d52cf4b8931e4d4a97173e7e6f955e02
Autor:
Megan L, Uhelski, Malcolm E, Johns, Alec, Horrmann, Sadiq, Mohamed, Ayesha, Sohail, Iryna A, Khasabova, Donald A, Simone, Ratan K, Banik
Publikováno v:
Molecular pain. 18
Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdde8811ee09494fc3fa2e16b6942904
https://pubmed.ncbi.nlm.nih.gov/36408567
https://pubmed.ncbi.nlm.nih.gov/36408567
Autor:
Iryna I. Khasabova, Joseph Juliette, Victoria M. Rogness, Sergey G. Khasabov, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, John D. Belcher, Gregory M. Vercellotti, Virginia S. Seybold, Donald A. Simone
Publikováno v:
Blood. 140(16)
In order to better understand mechanisms underlying acute pain during vaso-occlusive crises (VOCs) in patients with sickle cell disease, Khasabova et al report on a clinically relevant model in mice where VOC is stimulated by exposure to cold. Cold e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf74be60d0e81aa7d516729770bd64b
https://pubmed.ncbi.nlm.nih.gov/35960856
https://pubmed.ncbi.nlm.nih.gov/35960856
Autor:
Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman
Publikováno v:
Blood. 140:2500-2501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845d6e743b83025973eaf201b8ee8ad0
https://doi.org/10.1182/blood-2022-163508
https://doi.org/10.1182/blood-2022-163508
Autor:
Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti
Publikováno v:
Blood. 140:443-444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af633f5eca78efadbb845965fd36ae1e
https://doi.org/10.1182/blood-2022-157597
https://doi.org/10.1182/blood-2022-157597
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain
Autor:
Iryna A. Khasabova, Michelle Holman, Tim Morse, Natalya Burlakova, Lia Coicou, Catherine Harding-Rose, Don A. Simone, Virginia S. Seybold
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 19-28 (2013)
Opioids do not effectively manage pain in many patients with advanced cancer. Because anandamide (AEA) activation of cannabinoid type-1 receptors (CB1R) on nociceptors reduces nociception, manipulation of AEA metabolism in the periphery may be an eff
Externí odkaz:
https://doaj.org/article/18b32005c5cb485eb8ff67c5682d9358
Autor:
Donald A. Simone, Sergey G. Khasabov, Megan L. Uhelski, Virginia S. Seybold, Kalpna Gupta, Iryna A. Khasabova
Publikováno v:
Blood. 133:1989-1998
Pain is a characteristic feature of sickle cell disease (SCD), 1 of the most common inherited diseases. Patients may experience acute painful crises as well as chronic pain. In the Berkley transgenic murine model of SCD, HbSS-BERK mice express only h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ca80fb61d304f2d9371cacad36d1b1
https://doi.org/10.1182/blood-2018-11-884346
https://doi.org/10.1182/blood-2018-11-884346
Publikováno v:
Neurosci Lett
Although millions of people are diagnosed with cancer each year, survival has never been greater thanks to early diagnosis and treatments. Powerful chemotherapeutic agents are highly toxic to cancer cells, but because they typically do not target can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7a2664c291bc4697d423a76132233
https://pubmed.ncbi.nlm.nih.gov/33774149
https://pubmed.ncbi.nlm.nih.gov/33774149
Autor:
Mikhail Y. Golovko, Sergey G. Khasabov, Iryna A. Khasabova, Svetlana A. Golovko, Donald A. Simone
Publikováno v:
Prostaglandins Other Lipid Mediat
Pain produced by bone cancer is often severe and difficult to treat. Here we examined effects of Resolvin D1 (RvD1) or E1 (RvE1), antinociceptive products of ω−3 polyunsaturated fatty acids, on cancer-induced mechanical allodynia and heat hyperalg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbc82ca22dfc645be505023addd0c4f
https://pubmed.ncbi.nlm.nih.gov/32745525
https://pubmed.ncbi.nlm.nih.gov/32745525