Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Irwin J. Kurland"'
Autor:
Sneha Mishra, Claudia Cosentino, Ankit Kumar Tamta, Danish Khan, Shalini Srinivasan, Venkatraman Ravi, Elena Abbotto, Bangalore Prabhashankar Arathi, Shweta Kumar, Aditi Jain, Anand S. Ramaian, Shruti M. Kizkekra, Raksha Rajagopal, Swathi Rao, Swati Krishna, Ninitha Asirvatham-Jeyaraj, Elizabeth R. Haggerty, Dafne M. Silberman, Irwin J. Kurland, Ravindra P. Veeranna, Tamilselvan Jayavelu, Santina Bruzzone, Raul Mostoslavsky, Nagalingam R. Sundaresan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Chronic stress induces skeletal muscle atrophy via upregulation of glucocorticoid levels. Here, the authors show that SIRT6 transcriptionally regulates glucocorticoid-induced muscle atrophy by modulating IGF/PI3K/AKT signalling.
Externí odkaz:
https://doaj.org/article/d4cbf3bac7a14798ba51e0d8aeaeb195
Autor:
Qingkui Jiang, Yunping Qiu, Irwin J. Kurland, Karl Drlica, Selvakumar Subbian, Sanjay Tyagi, Lanbo Shi
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT In response to Mycobacterium tuberculosis infection, macrophages mount proinflammatory and antimicrobial responses similar to those observed in M1 macrophages activated by lipopolysaccharide (LPS) and interferon gamma (IFN-γ). A metabolic r
Externí odkaz:
https://doaj.org/article/23475556c712462c94db85b48b4cf5bf
Autor:
Jee-Young Moon, Christine P. Zolnik, Zheng Wang, Yunping Qiu, Mykhaylo Usyk, Tao Wang, Jorge R. Kizer, Alan L. Landay, Irwin J. Kurland, Kathryn Anastos, Robert C. Kaplan, Robert D. Burk, Qibin Qi
Publikováno v:
EBioMedicine, Vol 37, Iss , Pp 392-400 (2018)
Background: Gut microbiota alteration has been implicated in HIV infection and metabolic disorders. The relationship between gut microbiota and diabetes has rarely been studied in HIV-infected individuals, who have excess risk of metabolic disorders.
Externí odkaz:
https://doaj.org/article/d04761f2339b41119308a1adbae86011
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102973- (2020)
Background: Stereotactic body radiotherapy (SBRT) is an effective treatment for hepatocellular carcinoma (HCC). This study sought to identify differentially expressed plasma metabolites in HCC patients at baseline and early during SBRT, and to explor
Externí odkaz:
https://doaj.org/article/53ed8600c690465a835a53c5f0ef8fd8
Autor:
John A. Bowden, Alan Heckert, Candice Z. Ulmer, Christina M. Jones, Jeremy P. Koelmel, Laila Abdullah, Linda Ahonen, Yazen Alnouti, Aaron M. Armando, John M. Asara, Takeshi Bamba, John R. Barr, Jonas Bergquist, Christoph H. Borchers, Joost Brandsma, Susanne B. Breitkopf, Tomas Cajka, Amaury Cazenave-Gassiot, Antonio Checa, Michelle A. Cinel, Romain A. Colas, Serge Cremers, Edward A. Dennis, James E. Evans, Alexander Fauland, Oliver Fiehn, Michael S. Gardner, Timothy J. Garrett, Katherine H. Gotlinger, Jun Han, Yingying Huang, Aveline Huipeng Neo, Tuulia Hyötyläinen, Yoshihiro Izumi, Hongfeng Jiang, Houli Jiang, Jiang Jiang, Maureen Kachman, Reiko Kiyonami, Kristaps Klavins, Christian Klose, Harald C. Köfeler, Johan Kolmert, Therese Koal, Grielof Koster, Zsuzsanna Kuklenyik, Irwin J. Kurland, Michael Leadley, Karen Lin, Krishna Rao Maddipati, Danielle McDougall, Peter J. Meikle, Natalie A. Mellett, Cian Monnin, M. Arthur Moseley, Renu Nandakumar, Matej Oresic, Rainey Patterson, David Peake, Jason S. Pierce, Martin Post, Anthony D. Postle, Rebecca Pugh, Yunping Qiu, Oswald Quehenberger, Parsram Ramrup, Jon Rees, Barbara Rembiesa, Denis Reynaud, Mary R. Roth, Susanne Sales, Kai Schuhmann, Michal Laniado Schwartzman, Charles N. Serhan, Andrej Shevchenko, Stephen E. Somerville, Lisa St. John-Williams, Michal A. Surma, Hiroaki Takeda, Rhishikesh Thakare, J. Will Thompson, Federico Torta, Alexander Triebl, Martin Trötzmüller, S. J. Kumari Ubhayasekera, Dajana Vuckovic, Jacquelyn M. Weir, Ruth Welti, Markus R. Wenk, Craig E. Wheelock, Libin Yao, Min Yuan, Xueqing Heather Zhao, Senlin Zhou
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2275-2288 (2017)
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950–Metabolites in Frozen Human Plasma
Externí odkaz:
https://doaj.org/article/e757670a32e84af9bc9bad52c975b5dc
Autor:
Ryan O. Walters, Esperanza Arias, Antonio Diaz, Emmanuel S. Burgos, Fangxia Guan, Simoni Tiano, Kai Mao, Cara L. Green, Yungping Qiu, Hardik Shah, Donghai Wang, Adam D. Hudgins, Tahmineh Tabrizian, Valeria Tosti, David Shechter, Luigi Fontana, Irwin J. Kurland, Nir Barzilai, Ana Maria Cuervo, Daniel E.L. Promislow, Derek M. Huffman
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 663-676.e6 (2018)
Summary: A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the
Externí odkaz:
https://doaj.org/article/d0b812ca5b9349d5909aebb22098bc5a
Autor:
Zheng Wang, Christine P. Zolnik, Yunping Qiu, Mykhaylo Usyk, Tao Wang, Howard D. Strickler, Carmen R. Isasi, Robert C. Kaplan, Irwin J. Kurland, Qibin Qi, Robert D. Burk
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Background: Integrated microbiome and metabolomics analyses hold the potential to reveal interactions between host and microbiota in relation to disease risks. However, there are few studies evaluating how field methods influence fecal microbiome cha
Externí odkaz:
https://doaj.org/article/09c4b15e117645049d680e05c6710e10
Autor:
Ji Miao, Joel T. Haas, Praveen Manthena, Yanning Wang, Enpeng Zhao, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Sudha B. Biddinger
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 659-667 (2014)
The liver plays a central role in metabolism and mediating insulin action. To dissect the effects of insulin on the liver in vivo, we have studied liver insulin receptor knockout (LIRKO) mice. Because LIRKO livers lack insulin receptors, they are una
Externí odkaz:
https://doaj.org/article/69fcdeed9f8844519c772ce2240e6837
Autor:
Yunping Qiu, Robyn D. Moir, Ian M. Willis, Suresh Seethapathy, Robert C. Biniakewitz, Irwin J. Kurland
Publikováno v:
Metabolites, Vol 8, Iss 1, p 9 (2018)
Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to
Externí odkaz:
https://doaj.org/article/0cdbc2355c5c42c2aa3602b0a7bc86eb
Autor:
Zhongbo Liu, Pasha Apontes, Ekaterina V. Fomenko, Nan Chi, Victor L. Schuster, Irwin J. Kurland, Jeffrey E. Pessin, Yuling Chi
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 201 (2018)
One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by skeletal muscle, which can be exacerbated by chronic high caloric intake. Previously, we identified a natural compound, mangiferin (MGF) that improved glucose u
Externí odkaz:
https://doaj.org/article/f2798a73354f4a8db557b0ad41584f8c