Zobrazeno 1 - 10
of 544
pro vyhledávání: '"Irwin J. Kopin"'
Autor:
Irwin J. Kopin, David S. Goldstein
Publikováno v:
Autonomic Neuroscience. 208:15-28
In this review we describe a series of major concepts introduced during the past 150 years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3727e2a21fba042c780ee4fd0b37c
https://doi.org/10.1016/j.autneu.2017.09.001
https://doi.org/10.1016/j.autneu.2017.09.001
Autor:
Patricia Sullivan, Courtney Holmes, Yunden Jinsmaa, Yehonatan Sharabi, Irwin J. Kopin, David S. Goldstein
Publikováno v:
Parkinsonism & Related Disorders. 31:79-86
There is intense interest in identifying cerebrospinal fluid (CSF) biomarkers of Parkinson's disease (PD), both for early diagnosis and to track effects of putative treatments. Nigrostriatal dopamine depletion characterizes PD. Predictably, CSF level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4868e5fe24ef36b89a0f9e525c7ecf
https://doi.org/10.1016/j.parkreldis.2016.07.009
https://doi.org/10.1016/j.parkreldis.2016.07.009
Autor:
David S. Goldstein, Patti Sullivan, Yehonatan Sharabi, Courtney Holmes, Irwin J. Kopin, Yunden Jinsmaa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:484-493
According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Monoamine oxidase-A (MAO-A) catalyzes the conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d7070c2bb5c67a63e6780a537bda27
https://doi.org/10.1124/jpet.115.230201
https://doi.org/10.1124/jpet.115.230201
Autor:
Deborah C. Mash, Ellen Sidransky, Courtney Holmes, Alessandro Stefani, Irwin J. Kopin, David S. Goldstein, Patti Sullivan, Yehonatan Sharabi
Publikováno v:
Parkinsonism & Related Disorders. 21:1013-1022
Several neurodegenerative diseases involve loss of catecholamine neurons--Parkinson's disease (PD) is a prototypical example. Catecholamine neurons are rare in the nervous system, and why they are lost has been mysterious. Accumulating evidence suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412ee1d1277e9f8cd17f9891e58df770
https://doi.org/10.1016/j.parkreldis.2015.07.009
https://doi.org/10.1016/j.parkreldis.2015.07.009
Autor:
Adele Cooney, Yunden Jinsmaa, Yehonatan Sharabi, David S. Goldstein, Irwin J. Kopin, Patti Sullivan
Publikováno v:
Journal of Neurochemistry. 133:14-25
Repeated systemic administration of the mitochondrial complex I inhibitor rotenone produces a rodent model of Parkinson's disease (PD). Mechanisms of relatively selective rotenone-induced damage to nigrostriatal dopaminergic neurons remain incomplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cc67357d238524827b5fb70d27f314
https://doi.org/10.1111/jnc.13042
https://doi.org/10.1111/jnc.13042
Autor:
Irwin J. Kopin, David S. Goldstein
Publikováno v:
Cellular and molecular neurobiology. 38(1)
In this Focused Review, we provide an update about evolving concepts that may link chronic stress and catecholamine autotoxicity with neurodegenerative diseases such as Parkinson's disease. Richard Kvetnansky's contributions to the field of stress an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778e8008f7067f8c5167d88e9b389408
https://pubmed.ncbi.nlm.nih.gov/28488009
https://pubmed.ncbi.nlm.nih.gov/28488009
Autor:
Deborah C. Mash, Patti Sullivan, Yehonatan Sharabi, David S. Goldstein, Courtney Holmes, Irwin J. Kopin
Severe putamen dopamine depletion characterizes Parkinson's disease (PD) and multiple system atrophy (MSA). The extent of the depletion is greater than can be accounted for by loss of nigrostriatal dopaminergic terminals alone. We used putamen tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f970d176c6baa9dacad9c09dd7d7a0ac
https://europepmc.org/articles/PMC6319359/
https://europepmc.org/articles/PMC6319359/
Autor:
Steven Vernino, Courtney Holmes, Bobby Pourier, Patti Sullivan, Risa Isonaka, Elizabeth Zhong, David S. Goldstein, Vincenzo Donadio, Irwin J. Kopin, Yehonatan Sharabi
Publikováno v:
Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 27(1)
We report a case of autoimmunity-associated autonomic failure in a young adult woman who developed arthritis followed 3 years later by pandysautonomia. There was early recovery of parasympathetic functions but persistent neurogenic orthostatic hypote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61329e4324f61d7e59368b06689707df
https://pubmed.ncbi.nlm.nih.gov/27838780
https://pubmed.ncbi.nlm.nih.gov/27838780
Autor:
Courtney Holmes, Yehonatan Sharabi, Irwin J. Kopin, Patti Sullivan, David S. Goldstein, Yunden Jinsmaa
Publikováno v:
Neurochemical research. 41(9)
The catecholaldehyde hypothesis predicts that monoamine oxidase (MAO) inhibition should slow the progression of Parkinson's disease, by decreasing production of the autotoxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL). Inhibiting MAO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbdbed5da377cedbfdf2cd6714ba3b4
https://pubmed.ncbi.nlm.nih.gov/27220335
https://pubmed.ncbi.nlm.nih.gov/27220335
Autor:
Yunden Jinsmaa, Yehonatan Sharabi, Courtney Holmes, Rachel Sullivan, Irwin J. Kopin, Daniel J. Gross, Patti Sullivan, David S. Goldstein, Adele Cooney
Publikováno v:
Journal of Neurochemistry. 123:932-943
Parkinson's disease entails profound loss of nigrostriatal dopaminergic terminals, decreased vesicular uptake of intraneuronal catecholamines, and relatively increased putamen tissue concentrations of the toxic dopamine metabolite, 3,4-dihydroxypheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be0b18b3af49d961c4abc52e898c8db
https://doi.org/10.1111/j.1471-4159.2012.07924.x
https://doi.org/10.1111/j.1471-4159.2012.07924.x