Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Irwin I. Singer"'
Autor:
Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka
Publikováno v:
Physiological Genomics. 45:47-57
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atheroscleros
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1771:45-54
We have performed double-label immunofluorescence microscopy studies to evaluate the extent of co-localization of prostacyclin synthase (PGIS) and thromboxane synthase (TXS) with cyclooxygenase (COX)-1 and COX-2 in normal aortic endothelium. In dogs,
Autor:
Gloria J.-F. Ding, George A. Doherty, Douglas W. Kawka, William K. Hagmann, Irwin I. Singer, Richard Wnek, Xin Chun Tong, Jianying Xiao, R. Blake Pepinsky, Kashmira Shah, Gloria C. Koo, Lin Kochung
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 167:1400-1409
A nonpeptidyl small molecule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in lung inflammation induced by a single dose of ovalbumin challenge. Compound A presented a good pharmacokinetic property, when given intrat
Autor:
S Scott, Sandra L. Gould, Jayne Chin, Lorraine Malkowitz, Janet Lineberger, Salvatore J. Siciliano, Julie A. DeMartino, Hollis R. Williams, Lyndon J. Mitnaul, Michael D. Miller, Jerry DiSalvo, Mary Jo Staruch, Douglas W. Kawka, Irwin I. Singer, H J Zweerink, Martin S. Springer, Bruce L. Daugherty
Publikováno v:
Journal of Virology. 75:3779-3790
The chemokine receptors CCR5 and CXCR4 act synergistically with CD4 in an ordered multistep mechanism to allow the binding and entry of human immunodeficiency virus type 1 (HIV-1). The efficiency of such a coordinated mechanism depends on the spatial
Autor:
Ellen K. Bayne, Robin Poole, Wim B. van den Berg, Clark Billinghurst, John S. Mudgett, Pieter Buma, Peter L E M van Lent, Irwin I. Singer, Peter M. van der Kraan, A.E.M. Holthuysen, Reinout Stoop, Joyce B. J. van Meurs
Publikováno v:
Arthritis & Rheumatism. 42:2074-2084
Objective The destruction of articular cartilage during arthritis is due to proteolytic cleavage of the extracellular matrix components. This study investigates the kinetic involvement of metalloproteinases (MMPs) in the degradation of the 2 major ca
Autor:
B. Azzolina, Julia M. Ayala, B. Chang, M. Einstein, Diane Thiboutot, Richard A. Mumford, John G. Flanagan, Georgianna Harris, Irwin I. Singer, Ellen K. Bayne, David A. Whiting
Publikováno v:
British Journal of Dermatology. 141:481-491
The predominant form of 5alpha-reductase (5aR) in human scalp is 5aR1. None the less, clinical studies have shown that finasteride, a selective inhibitor of 5aR2, decreases scalp dihydrotestosterone and promotes hair growth in men with androgenetic a
Autor:
Joyce B. J. van Meurs, Wim B. van den Berg, Peter L E M van Lent, A.E.M. Holthuysen, Ellen K. Bayne, Irwin I. Singer
Publikováno v:
Arthritis & Rheumatism. 42:1128-1139
Objective Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme termed aggrecanase, have been observed in aggrecan. To learn more about the relative contribution of these enzymes during car
Autor:
William F. Stenson, Teresa G. Tessner, Suzanne Schloemann, Irwin I. Singer, Douglas W. Kawka, Terrence E. Riehl
Publikováno v:
Gastroenterology. 115:297-306
Background & Aims: Prostaglandins are synthesized by cyclooxygenases (COX)-1 and -2. The expression and cellular localization of COX-1 and COX-2 in normal human colon and inflammatory bowel disease (IBD) surgical resections were studied. Methods: COX
Autor:
Irwin I. Singer, Wim B. van den Berg, Fons A. J. van de Loo, Ellen K. Bayne, Joyce B. J. van Meurs, Peter L E M van Lent
Publikováno v:
Arthritis & Rheumatism. 41:647-656
Objective To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteoglycan (PG) loss in arthritis, and to examine the role of interleukin-1 (IL-1) in VDIPEN expression. Methods VDIPEN exp
Publikováno v:
Journal of Biological Chemistry. 273:9886-9893
Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen. These enzymes catalyze the committed step in the formation of prostanoids from arachidonic acid.