Výsledky vyhledávání - "Irwin H. Lepow"

Structural Features and Biologic Properties of Fragments Obtained by Limited Proteolysis of C3

Autor: Mary Carol Conroy, Juris Ozols, Irwin H. Lepow

Publikováno v: The Journal of Immunology. 116:1682-1687

Limited proteolysis of the third component of human complement (C3) was performed by using trypsin and streptococcal proteinase and the digests were analyzed for biologic activity. Incubation of C3 with trypsin for 1 min yielded a peptide with smooth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a67c1ffcc33ba9d07409c3330b6b8ccc
https://doi.org/10.4049/jimmunol.116.6.1682

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Studies on the sub-unit structure of human properdin

Autor: Irwin H Lepow, J.Odura Minta

Publikováno v: Immunochemistry. 11:361-368

Human properdin contains 9.8% carbohydrate consisting of 3.8% hexose, 0.7% fucose, 1.5% hexosamine and 3.8% sialic acid. The partial specific volume for properdin calculated from amino acid composition and carbohydrate analysis was 0.7 cc/g. The mol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fe69661ef5838c615582c9b5dd3191
https://doi.org/10.1016/0019-2791(74)90189-x

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Metabolism of properdin in normal subjects and patients with renal disease

Autor: Chester A. Alper, John B. Ziegler, Irwin H. Lepow, Fred S. Rosen, W Grupe

Publikováno v: Journal of Clinical Investigation. 56:761-767

Properdin deposition has been recognized in glomeruli of patients with acute and chronic nephritis and lupus nephritis, and low serum properdin levels have been found in these disorders. These findings suggest that properdin may be involved in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb89e0c6465818037c34d72703824c
https://doi.org/10.1172/jci108147

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COMPLEMENT AS A MEDIATOR OF INFLAMMATION

Autor: W. Dias da Silva, Irwin H. Lepow

Publikováno v: The Journal of Experimental Medicine

Interaction in free solution of highly purified preparations of human C'1 esterase, C'4, C'2, and C'3, in the presence of Mg2+, resulted in rapid generation of an activity indistinguishable by biological criteria from anaphylatoxin. The formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02c9cac9338be9acba74218a692848d
http://europepmc.org/articles/PMC2138204

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COMPLEMENT AS A MEDIATOR OF INFLAMMATION

Autor: Irwin H. Lepow, Oscar D. Ratnoff

Publikováno v: Journal of Experimental Medicine. 118:681-698

Purified preparations of the esterase derived from the first component of complement (C'1 esterase) increased vascular permeability in guinea pig skin, an effect inhibited by triprolidine, an antihistaminic agent, but not by soy bean trypsin inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f72cd46ac68181f82a70f0b4a8226507
https://doi.org/10.1084/jem.118.5.681

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Studies on the Mechanism of Inactivation of Human Complement by Plasmin and by Antigen-Antibody Aggregates

Autor: Irwin H. Lepow, Louis Pillemer, Leona Wurz

Publikováno v: The Journal of Immunology. 75:63-70

Discussion and Summary The experiments which have been summarized above indicate that the inactivation of human C′ by antigen-antibody aggregates occurs in two distinct stages. The first, designated the activation stage, appears to be a reaction be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b83048a9883b39fd50ba1651b532fad2
https://doi.org/10.4049/jimmunol.75.1.63

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Enhancement of Vascular Permeability by Mixtures of C'l Esterase and Normal Serum

Autor: Irwin H. Lepow, R. D. Smink, Oscar D. Ratnoff, Rachel W. Abernethy

Publikováno v: Experimental Biology and Medicine. 116:280-283

SummaryConcentrations of human C'1 esterase which are below threshold for direct enhancement of vascular permeability in guinea pig skin have been shown capable of generating a partially heat stable (56†C, 30 minutes) permeability factor from norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56cbe2a4e63bda9baad082245d2f049b
https://doi.org/10.3181/00379727-116-29226

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An Investigation of the Streaming Birefringence of Amylose Solutions1

Autor: Irwin H. Lepow, Joseph F. Foster

Publikováno v: Journal of the American Chemical Society. 70:4169-4173

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::009124c8646ba72136bc3c19456cab54
https://doi.org/10.1021/ja01192a056

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Anaphylatoxin Formation by Purified Human C′1 Esterase

Autor: W. Dias da Silva, Irwin H. Lepow

Publikováno v: The Journal of Immunology. 95:1080-1089

Summary Incubation of purified human C′1 esterase with guinea pig or rat plasma or serum produced a smooth muscle stimulating activity with the following properties: a) contraction of guinea pig ileum which was made unresponsive after a few applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59e693c8a615c1318e53b2bd43ca11c1
https://doi.org/10.4049/jimmunol.95.6.1080

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