Zobrazeno 1 - 10
of 3 262
pro vyhledávání: '"Irwin H"'
Autor:
Hidehiro Ishikawa, Shintaro Kimura, Hajime Takase, Maximillian Borlongan, Norito Fukuda, Tomonori Hoshino, Gen Hamanaka, Ji Hyun Park, Akihiro Shindo, Kyu-Won Kim, Irwin H. Gelman, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules. While recent studies suggest an important role for AKAP12 in the brain,
Externí odkaz:
https://doaj.org/article/783e15139445421ea37939fd2508fa49
Autor:
Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Arai
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such
Externí odkaz:
https://doaj.org/article/1fd76de251144c16af1a0bf481a6830d
Autor:
Jianliang Zhang, Irwin H. Gelman, Eriko Katsuta, Yuanzi Liang, Xue Wang, Jun Li, Jun Qu, Li Yan, Kazuaki Takabe, Steven N. Hochwald
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 1, Pp 37-60 (2019)
Background & Aims: Most targeted therapies against cancer are designed to block growth factor–stimulated oncogenic growth. However, response rates are low, and resistance to therapy is high. One mechanism might relate to the ability of tumor cells
Externí odkaz:
https://doaj.org/article/74e2c81b333044c0b4f350fb137465bb
VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
Autor:
Yinglong Zhang, He Shen, Henry G. Withers, Nuo Yang, Kayla E. Denson, Ashley L. Mussell, Alexander Truskinovsky, Qingyu Fan, Irwin H. Gelman, Costa Frangou, Jianmin Zhang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety of environmental cues. Recently, VGLL proteins have been proposed to regulate key signaling networks involved in
Externí odkaz:
https://doaj.org/article/e5cb097cea444e6e89789de7e2797e41
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205608 (2018)
How TATA-less promoters such as those within CpG islands (CGI) control gene expression is still a subject of active research. Here, we have identified the "CGCG element", a ten-base pair motif with a consensus sequence of TCTCGCGAGA present in a grou
Externí odkaz:
https://doaj.org/article/48c085b1a6fd497399356d90f7b650ef
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 28-29 (2016)
Externí odkaz:
https://doaj.org/article/4d40cd3a27b445a893717ea875846e1c
Autor:
Bing Su, Lingqiu Gao, Catherine Baranowski, Bryan Gillard, Jianmin Wang, Ryan Ransom, Hyun-Kyung Ko, Irwin H Gelman
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101411 (2014)
Activation of the PI3K/AKT signal pathway is a known driving force for the progression to castration-recurrent prostate cancer (CR-CaP), which constitutes the major lethal phenotype of CaP. Here, we identify using a genomic shRNA screen the PI3K/AKT-
Externí odkaz:
https://doaj.org/article/62c6603094bd48c2ba6bb965dd9d3960
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111534 (2014)
Chemotaxis is controlled by interactions between receptors, Rho-family GTPases, phosphatidylinositol 3-kinases, and cytoskeleton remodeling proteins. We investigated how the metastasis suppressor, SSeCKS, attenuates chemotaxis. Chemotaxis activity in
Externí odkaz:
https://doaj.org/article/61de1cbc098c408b944d283c47602022