Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Irwin Freed"'
Autor:
William Matsui, David M. Berman, Christine A. Iacobuzio-Donahue, N. V. Rajeshkumar, Michael Goggins, Daniel A. Laheru, Zeshaan A. Rasheed, Anirban Maitra, Christopher Murter, Jan Bart M. Koorstra, Jeanne Kowalski, Irwin Freed, Jie Yang, Manuel Hidalgo, Antonio Jimeno, Qiuju Wang, Seung-Mo Hong, Xiaobing He
Publikováno v:
JNCI: Journal of the National Cancer Institute. 102:340-351
Background Specific populations of highly tumorigenic cells are thought to exist in many human tumors, including pancreatic adenocarcinoma. However, the clinical significance of these tumor-initiating (ie, cancer stem) cells remains unclear. Aldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53756c7710fd2517bf402628b85ab17d
https://doi.org/10.1093/jnci/djp535
https://doi.org/10.1093/jnci/djp535
Autor:
Brandon Luber, Theresa S. Pritchard, Shuming Chen, Irwin Freed, Tracee L. McMiller, Janice Davis Sproul, Susan Sartorius-Mergenthaler, Hao Wang, Sowmya Ravi, Drew M. Pardoll, Evan J. Lipson, Suzanne L. Topalian, William H. Sharfman, Janis M. Taube, January T. Salas
Publikováno v:
Journal of Translational Medicine
Background Limited adjuvant treatment options exist for patients with high-risk surgically resected melanoma. This first-in-human study investigated the safety, tolerability and immunologic correlates of Melanoma GVAX, a lethally irradiated granulocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa0c25ea66db4a522ce4bc9b4f06613
https://doi.org/10.1186/s12967-015-0572-3
https://doi.org/10.1186/s12967-015-0572-3
Autor:
Daniel N. Sauder, Shabana Shahid, Gulnar M. Shivji, Tak W. Mak, Irwin Freed, Lihua Zhuang, Hiroshi Fujisawa, Brandon G. Howell, Binghe Wang
Publikováno v:
The Journal of Immunology. 165:6783-6790
The role of CD4+ vs CD8+ T cells in contact hypersensitivity (CHS) remains controversial. In this study, we used gene knockout (KO) mice deficient in CD4+ or CD8+ T cells to directly address this issue. Mice lacking either CD4+ or CD8+ T cells demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ab1f465bc5fe7b65112adc640b1b45
https://doi.org/10.4049/jimmunol.165.12.6783
https://doi.org/10.4049/jimmunol.165.12.6783
Autor:
Hideaki Watanabe, Adam J. Mamelak, Elliot Weiss, Binghe Wang, Irwin Freed, Angela K. Brice, Lynn Wachtman, Kathleen L. Gabrielson, Naoko Yokota, Daniel J. Hicklin, Robert S. Kerbel, Mark Haas, Daniel N. Sauder
Publikováno v:
Clinical Cancer Research. 11:407-409
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846f9496cd34c59862b90d54e304cf26
https://doi.org/10.1158/1078-0432.407.11.1
https://doi.org/10.1158/1078-0432.407.11.1
Autor:
Masashi Nakayama, Hideaki Watanabe, Irwin Freed, Brandon G. Howell, Daniel N. Sauder, Binghe Wang, Robert S. Kerbel, Go Nagasaki, Clemens Esche, Daniel J. Hicklin, Adam J. Mamelak
Publikováno v:
Experimental dermatology. 13(11)
The angiogenic mediator vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have been studied extensively in neoplastic disease and some inflammatory conditions. Contact hypersensitivity (CHS) is a prototypic Langerhans' cell-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702ae4ab790092cab61492f842178ebd
https://pubmed.ncbi.nlm.nih.gov/15500639
https://pubmed.ncbi.nlm.nih.gov/15500639
Autor:
Binghe Wang, Irwin Freed, Nowell Solish, Chao Lu, Hideaki Watanabe, Brandon G. Howell, Daniel N. Sauder, Adam J. Mamelak
Publikováno v:
Journal of dermatological science. 39(1)
Summary Purpose: Basal cell carcinoma (BCC) is the most common human neoplasm. Much interest lies in determining the genetic basis of BCC to explain the unique locally invasive phenotype and infrequent metastatic behavior of these skin tumors. Object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f757d73398c1d0f366cf40f20e84bec4
https://pubmed.ncbi.nlm.nih.gov/15978418
https://pubmed.ncbi.nlm.nih.gov/15978418
Publikováno v:
Cytokinegrowth factor reviews. 14(5)
Contact hypersensitivity (CHS) is a Langerhans cell (LC)-dependent, T cell-mediated cutaneous immune response. CHS reflects a culmination of LC activities in vivo: uptake of epicutaneous antigens, migration into lymph nodes, and presentation of antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89051627efc7f1395b3852d6bd61e729
https://pubmed.ncbi.nlm.nih.gov/12948522
https://pubmed.ncbi.nlm.nih.gov/12948522
Autor:
Brandon G. Howell, Irwin Freed, Daniel N. Sauder, Binghe Wang, Adam J. Mamelak, Hideaki Watanabe
Publikováno v:
Journal of dermatological science. 34(3)
Background : Ultraviolet (UV) B light is an environmental mutagen that induces changes in cutaneous gene expression leading to immune suppression and carcinogenesis. Keratinocytes are a primary target for UVB. Objective : To further delineate UVB-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c5e92799ead463d241c8bcf098654d
https://pubmed.ncbi.nlm.nih.gov/15113588
https://pubmed.ncbi.nlm.nih.gov/15113588
Autor:
Brandon G. Howell, Qinchao Cai, Claudio Feliciani, Binghe Wang, Hideaki Watanabe, Irwin Freed, Daniel N. Sauder
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 168(7)
The epidermal Langerhans cells (LC), a member of the dendritic cell family, and the LC-derived cytokine IL-12 play a pivotal role in the initiation of contact hypersensitivity (CHS), a Th1 immune response in the skin. Because IL-18, another LC-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1995b4d2c4e282600b2e8ae632c3bca3
https://pubmed.ncbi.nlm.nih.gov/11907086
https://pubmed.ncbi.nlm.nih.gov/11907086
Publikováno v:
Journal of leukocyte biology. 70(2)
Contact hypersensitivity (CHS), a dendritic-cell (DC)-dependent, T-cell-mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7614cc570b9bf05eaf15298b5b8b2b43
https://pubmed.ncbi.nlm.nih.gov/11493609
https://pubmed.ncbi.nlm.nih.gov/11493609