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Localization by whole-body autoradiography of intact and fragmented radiolabeled antibodies in a metastatic human colonic cancer model

Autor: John P. Grundy, Irwin Fand, Robert M. Sharkey, David M. Goldenberg

Publikováno v: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 19:87-99

In this report, we have employed macroautoradiography to compare the tumor targeting of 125I-labeled anti-carcinoembryonic antigen (CEA) MAb (NP-4) to 125I-labeled anti-colon-specific antigen-p (CSAp) MAb (Mu-9) and their labeled F(ab′)2 and Fab′

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5c1fc5adbd3c2ddca92169a81de8f
https://doi.org/10.1016/0883-2897(92)90190-a

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Tumor targeting in a murine tumor xenograft model with the (sFv')2 divalent form of anti-c-erbB-2 single-chain Fv

Autor: James S. Huston, Gregory P. Adams, John E. McCartney, Mei-Sheng Tai, Robert M. Hudziak, Hermann Oppermann, Walter F. Stafford, Sen Liu, Irwin Fand, Gerald Apell, Axel Laminet, Michael A. Bookman, L. L. Houston, Louis M. Weiner

Publikováno v: Cell biophysics.

This investigation has utilized novel forms of the single-chain Fv (sFv), wherein a cysteine-containing peptide has been fused to the sFv carboxyl terminus to facilitate disulfide bonding or specific cross-linking of this sFv' to make divalent (sFv')

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1182b4aa79de85594efb6e2275abef45
https://pubmed.ncbi.nlm.nih.gov/7736532

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The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: an autoradiographic study

Autor: David M. Goldenberg, Irwin Fand, Rosalyn D. Blumenthal, Rina Kashi, Otto C. Boerman, Robert M. Sharkey

Publikováno v: Cancer immunology, immunotherapy : CII. 33(6)

The inaccessibility of radiolabeled antibody to poorly vascularized regions of solid tumors may reduce the therapeutic efficacy of these macromolecules. Theoretical mathematical models have predicted that increasing the protein dose administered woul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93638104ce8aa2abccfd2edac81f3219
https://pubmed.ncbi.nlm.nih.gov/1652355

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Selection of a DTPA chelate conjugate for monoclonal antibody targeting to a human colonic tumor in nude mice

Autor: Robert M. Sharkey, Cecilia Motta-Hennessy, David M. Goldenberg, Otto A. Gansow, Martin W. Brechbiel, Irwin Fand, Anastasia L. Jones, Gary L. Griffiths

Publikováno v: International journal of cancer. 46(1)

Our previous studies with a 90Y-labelled antibody against carcinoembryonic antigen (CEA) conjugated to the cyclic anhydride-DTPA (CA-DTPA) indicated that the accretion of 90Y in the bone may limit the application of 90Y-labelled antibodies for therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e8e6f5b331046be336bed7c3f4ea9
https://pubmed.ncbi.nlm.nih.gov/2114375

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Whole-body autoradiographic localization of [3H]phencyclidine and its metabolites in mice

Autor: Prantika Som, Dale G. Deutsch, Omanand Koul, Yoshiharu Yonekura, Irwin Fand, W. P. McNally, A. Bertrand Brill

Publikováno v: Toxicology and Applied Pharmacology. 93:421-432

When evaluated by whole-body autoradiography (WBAR) and quantitative densitometry, [ 3 H]phencyclidine (PCP) equivalents were found to be removed rapidly from blood, after a single iv dose in mice, and avidly taken up as early as 1 min after dosage b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d1893b6a8bff4e131e6c69f8a256de
https://doi.org/10.1016/0041-008x(88)90045-2

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