Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Irwin D. Bernstein"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the tran
Externí odkaz:
https://doaj.org/article/134ccd270d5242848fcfcd4f706249e4
Autor:
Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109675- (2021)
Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyelo
Externí odkaz:
https://doaj.org/article/aeadf5874656435cb00af40d81bd981a
Autor:
Gene I. Uenishi, Ho Sun Jung, Akhilesh Kumar, Mi Ae Park, Brandon K. Hadland, Ethan McLeod, Matthew Raymond, Oleg Moskvin, Catherine E. Zimmerman, Derek J. Theisen, Scott Swanson, Owen J. Tamplin, Leonard I. Zon, James A. Thomson, Irwin D. Bernstein, Igor I. Slukvin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arteri
Externí odkaz:
https://doaj.org/article/1be185753919428b8cd64e6bff983c27
Autor:
Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y. Lucy Liu, Michele H. Cottler-Fox, Peter D. Emanuel, Martin Hauer-Jensen, Irwin D. Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J. Murray, Daohong Zhou
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 859-870 (2018)
Abstract: Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternat
Externí odkaz:
https://doaj.org/article/818b79add26b4135990fa6d6d894d3d2
Autor:
Brandon K. Hadland, Barbara Varnum-Finney, Pankaj K. Mandal, Derrick J. Rossi, Michael G. Poulos, Jason M. Butler, Shahin Rafii, Mervin C. Yoder, Momoko Yoshimoto, Irwin D. Bernstein
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1563-1572 (2017)
Recent evidence points to the embryonic emergence of some tissue-resident innate immune cells, such as B-1a lymphocytes, prior to and independently of hematopoietic stem cells (HSCs). However, whether the full hematopoietic repertoire of embryonic HS
Externí odkaz:
https://doaj.org/article/cccd9b3d8e5145308744a16958428633
Autor:
Yi-Fen Lu, Patrick Cahan, Samantha Ross, Julie Sahalie, Patricia M. Sousa, Brandon K. Hadland, Wenqing Cai, Erik Serrao, Alan N. Engelman, Irwin D. Bernstein, George Q. Daley
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3178-3192 (2016)
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch. Deriving HSCs from patient-matched embryonic/induced-pluripotent stem cells (ESCs/iPSCs) co
Externí odkaz:
https://doaj.org/article/679c902f28b84dce9db31c4a72891793
Autor:
James M. Olson, Phillip A. Beachy, Irwin D. Bernstein, Richard G. Ellenbogen, Thomas L. Russell, Beryl A. Hatton, Jennifer Stoeck, Mark Benson, Stacey Hansen, Joel I. Pritchard, Andrew R. Hallahan
3 Tables & 2 Figures from The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afb6326df8e499ad8616927be272d3c
https://doi.org/10.1158/0008-5472.22363295.v1
https://doi.org/10.1158/0008-5472.22363295.v1
Autor:
James M. Olson, Phillip A. Beachy, Irwin D. Bernstein, Richard G. Ellenbogen, Thomas L. Russell, Beryl A. Hatton, Jennifer Stoeck, Mark Benson, Stacey Hansen, Joel I. Pritchard, Andrew R. Hallahan
To develop a genetically faithful model of medulloblastoma with increased tumor incidence compared with the current best model we activated the Sonic Hedgehog (Shh) pathway by transgenically expressing a constitutively active form of Smoothened in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f70f02d1275ea5abcb5d4b88fde72b
https://doi.org/10.1158/0008-5472.c.6493643
https://doi.org/10.1158/0008-5472.c.6493643
Autor:
Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Blood. 140:8574-8575