Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Irwin A. Heyman"'
Publikováno v:
Fundamental and Applied Toxicology. 17:627-634
A battery of mutagenicity tests was performed with nafarelin, an agonist analogue of luteinizing hormone releasing hormone (LHRH) containing tryptophan (Trp) and histidine (His). Included were the Ames assay and the gene conversion assay with yeast s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52fad72f46c8a61199294e24fb81f5a8
https://doi.org/10.1016/0272-0590(91)90212-m
https://doi.org/10.1016/0272-0590(91)90212-m
Publikováno v:
Toxicological Sciences. 17:627-634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d92c06c6182868aa265f876db9627d8f
https://doi.org/10.1093/toxsci/17.3.627
https://doi.org/10.1093/toxsci/17.3.627
Autor:
Satt Tekeli, Farrel L. Fort, Irwin A. Heyman, James W. Kesterson, Patrick K. Cusick, Eugene T. Kimura, Bruno Buratto
Publikováno v:
Fundamental and Applied Toxicology. 4:827-842
A comparative toxicity and carcinogenicity study was carried out for 2 years with estazolam, a benzodiazepine, via diet in Sprague-Dawley rats (0.5, 2, and 10 mg/kg/day) and in B6C3F1 mice (0.8, 3, and 10 mg/kg/day). In rats, no biologically signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e071584b42767cb49d7560f302eeef7e
https://doi.org/10.1016/0272-0590(84)90105-2
https://doi.org/10.1016/0272-0590(84)90105-2
Publikováno v:
Toxicology and Applied Pharmacology. 28:18-27
In order to resolve the differences in reported LD50 values for Δ 9 -tetrahydrocannabinol ( Δ 9 -THC) obtained with various vehicles and rat strains, the oral LD50 values of Δ 9 -THC in a natural vegetable oil vehicle and in an aqueous emulsion we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6d11cccb358919f7f7600958d68679
https://doi.org/10.1016/0041-008x(74)90126-4
https://doi.org/10.1016/0041-008x(74)90126-4
Autor:
EUGENE T. KIMURA, FARREL L. FORT, BRUNO BURATTO, SATT TEKELI, JAMES W. KESTERSON, IRWIN A. HEYMAN, PATRICK K. CUSICK
Publikováno v:
Toxicological Sciences. 4:827-842
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751a00e54b0c87eebd0289d7d6a723b4
https://doi.org/10.1093/toxsci/4.5.827
https://doi.org/10.1093/toxsci/4.5.827
Autor:
Robert W. Fleischman, Vladimir Ilievski, Ulrich Schaeppi, Phelan R, Harris Rosenkrantz, Irwin A. Heyman
Publikováno v:
Toxicology and applied pharmacology. 27(2)
The toxicity of chromomycin A3, a potent antitumor antibiotic derived from Streptomyces griseus , was assessed in mice, dogs and monkeys. In mice, the LD50 after 5 daily iv doses was 603 μg/kg. In dogs and monkeys, the single-dose iv minimal lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249dd1f6e5441cfb4d41b51c52b58e98
https://pubmed.ncbi.nlm.nih.gov/4212258
https://pubmed.ncbi.nlm.nih.gov/4212258
Autor:
Irwin A. Heyman, Farrel L. Fort, Herman H. Stein, James W. Kesterson, Kingsley Langenberg, James P. Lewkowski
Publikováno v:
Toxicology. 28(4)
Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0509ac837b5fb5c42fb91bb50154ffc8
https://pubmed.ncbi.nlm.nih.gov/6606240
https://pubmed.ncbi.nlm.nih.gov/6606240
Publikováno v:
Toxicology and applied pharmacology. 32(2)
Groups of male and female Fischer rats were treated orally with Δ9-THC doses of 2, 10, or 50 mg/kg for 28, 90, and 180 days. Another group of rats treated for 180 days was studied after a 30-day recovery period. The lowest dose employed in the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1876ff04c3c5c01a192d8672b112e536
https://pubmed.ncbi.nlm.nih.gov/1171540
https://pubmed.ncbi.nlm.nih.gov/1171540
Autor:
Robert E. Plapinger, Garry A. Seligman, Hannah L. Wasserkrug, Irwin A. Heyman, Arnold M. Seligman, K. C. Padmanabhan, Donald A. Davis
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 20(3)
The first cytochemical demonstration of a hydrolytic enzyme using a single agent as both substrate and capture reagent to form an osmiophilic polymer was reported earlier. The first results were obtained with substrates containing an enzyme-susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1a40b45616acadebaac223d89178e8
https://pubmed.ncbi.nlm.nih.gov/4112909
https://pubmed.ncbi.nlm.nih.gov/4112909
Autor:
Phelan R, Irwin A. Heyman, Vladimir Ilievski, Ulrich Schaeppi, Ruth D. Davis, Harris Rosenkrantz, David A. Cooney, Robert W. Fleischman
Publikováno v:
Toxicology and applied pharmacology. 25(2)
cis-Dichlorodiammineplatinum(II), a compound with antineoplastic and antimitotic activity, which inhibited the synthesis of DNA and to a lesser extent of RNA and proteins, was submitted to a preclinical pharmacologic evaluation in 16 dogs, 10 monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbef329ccd1c246080c109f41891e2c1
https://pubmed.ncbi.nlm.nih.gov/4197634
https://pubmed.ncbi.nlm.nih.gov/4197634