Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Irvith M. Carvajal"'
Autor:
James William Bryson, Wai Leung Lau, John A. Brailsford, Miguel Moreta, Julie Su, Virginie Lafont, Martin C. Wright, Michael J. Smith, H. Nicholas Marsh, Anthony Barros, Sanjeev Gangwar, Jason Pinckney, Qiang Cong, Alban Allentoff, Christina Terragni, Dasa Lipovsek, Pete Z. Cotter, Michael Wallace, Irvith M. Carvajal, Cris Hollander, Wenying Li, O'neil Steven, Lifei Wang
Publikováno v:
Protein Engineering, Design and Selection
Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens—but the multi-day half-life of ADC leads t
Autor:
Hui Wei, Neil Mathias, Jessica C. Graham, Aaron P. Yamniuk, Bonnie Wang, Irvith M. Carvajal, Julien Susan D, Janet Gould, Helen G. Haggerty, Michael J. Graziano, Jedd Hillegass, Alex Kozhich, Todd Davidson
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 100
Protein therapeutics represent a rapidly growing proportion of new medicines being developed by the pharmaceutical industry. As with any new drug, an Occupational Exposure Limit (OEL) should be developed to ensure worker safety. Part of the OEL deter
Autor:
Rochelle Thomas, Andrea L. Tatum, Mary Struthers, Linhui Julie Su, Pete Z. Cotter, Qihong Zhao, Paul R. Mangan, Ruchira Das Gupta, Irvith M. Carvajal, Zheng Lin, Victoria Jenny, Jenny Xie, Caryn Picarillo, Brigitte Devaux, Noah Ditto, Elizabeth M. Heimrich, Xiaoxia Yang, Luisa Salter-Cid, Kim W. McIntyre, Stacey Skala, Yunling Song, David J. Shuster, Virna Borowski
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:152-165
Therapies targeting either interleukin (IL)-23 or IL-17 have shown promise in treating T helper 17 (Th17)-driven autoimmune diseases. Although IL-23 is a critical driver of IL-17, recognition of nonredundant and independent functions of IL-23 and IL-
Publikováno v:
Angiogenesis. 15:685-695
Increasing experimental evidence suggests that IGF-1 may modulate tumor angiogenesis via activation of the expression of VEGF in Ewing sarcomas and rhabdomyosarcomas. This study investigates the effects of the PEGylated Adnectins™ CT-322, a VEGFR2-
Autor:
Johnny C. Akers, Ralph Weissleder, Diahnn Futalan, Carlos Sánchez, Brent Morse, Nick Marsh, David D. Gonda, Bob S. Carter, Arnab Chakravarti, Kamalakannan Palanichamy, Justin K. Scheer, Clark C. Chen, J. Dawn Waters, Eric Furfine, Ayguen Sahin, Peter Waterman, Irvith M. Carvajal
Publikováno v:
Journal of Neuro-Oncology. 110:37-48
Glioblastomas are among the most aggressive human cancers, and prognosis remains poor despite presently available therapies. Angiogenesis is a hallmark of glioblastoma, and the resultant vascularity is associated with poor prognosis. The proteins tha
Autor:
Hiroki Nanri, Mark A. Perrella, Irvith M. Carvajal, Matthew D. Layne, Shaw-Fang Yet, Kuniaki Ejima, Bonna Ith
Publikováno v:
Antioxidants & Redox Signaling. 4:569-575
Heme oxygenase (HO) enzymes catalyze the initial reaction in heme catabolism. HO-1 is an inducible isoform that is up-regulated by diverse stimuli, including inflammatory cytokines and factors that promote oxidative stress. HO-1 is a cytoprotective e
Publikováno v:
Critical Care Medicine. 30:S36-S42
High-mobility group (HMG) proteins are architectural factors that have been shown to play a role in the transcriptional regulation of various mammalian genes. One family of HMG proteins, HMG-I/Y, is known to facilitate the initiation of gene transcri
Autor:
Ranjan Sen, Irvith M. Carvajal
Publikováno v:
The Journal of Immunology. 164:6332-6339
The TCRβ-chain gene enhancer activates transcription and V(D)J recombination in immature thymocytes. In this paper we present a systematic analysis of the elements that contribute to the activity of the murine TCRβ enhancer in mature and immature T
Autor:
H. Nicholas Marsh, Irvith M. Carvajal, Cload Sharon T, Ruchira Das Gupta, Zheng Lin, Paul E. Morin, Carolyn Cao, Linda Engle, Aaron P. Yamniuk, Michael L. Doyle, Ginger Chao, Michael L. Gosselin, Martin C. Wright, Tai W. Wong, Marco M. Gottardis, Daniel Cataldo, David Fabrizio, Jennifer Brown, Stuart Emanuel, Eric Furfine, Brent Morse, Jennifer Hosbach, Rong-Rong Zhu, Jochem Gokemeijer, Raymond T Camphausen, Elizabeth Fitzpatrick, Rolf Ryseck
Publikováno v:
mAbs. 3(1)
Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR), two transmembrane receptors that mediate prolifer
Autor:
Irvith M. Carvajal, Jeffrey D. Peterson, Miguel Moreta, Vera Delventhal, Maximilian Ackermann, Brent Morse, Eric Furfine, Sylvie Kossodo, Moritz A. Konerding, O'neil Steven, H. Nicholas Marsh
Publikováno v:
International Journal of Oncology. 38
Antiangiogenesis has become a promising pillar in modern cancer therapy. This study investigates the antiangiogenic effects of the PEGylated Adnectin™, CT-322, in a murine Colo-205 xenograft tumor model. CT-322 specifically binds to and blocks vasc