Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Irving Shemano"'
Autor:
Irving Shemano, Michael W. DeGregorio, Christopher C. Benz, Timothy B. Cadman, Valerie J. Wiebe
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:247-251
A multicenter phase I pharmacokinetic study of a new triphenylethylene antiestrogen, toremifene, was examined in 70 patients with advanced breast cancer. Patients were randomized to receive single daily oral doses of either 10, 20, 40, 60, 200, or 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cfd312a3239eb902e40fe0f04228d4
https://doi.org/10.1007/bf00684880
https://doi.org/10.1007/bf00684880
Autor:
W R Bezwoda, Daniel F. Hayes, R F Berris, J A Van Zyl, A Hacking, J A Mailliard, S E Jones, Charles L. Vogel, L Goedhals, Irving Shemano
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 13(10)
PURPOSE To perform a randomized three-arm comparison of tamoxifen (TAM; 20 mg/d) and two separate doses of toremifene (TOR; 60 mg/d [TOR60] and 200 mg/d [TOR200]) in postmenopausal patients with hormone receptor-positive or -unknown metastatic breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fd30528f452d4adfb3f2e8a9b9f584
https://pubmed.ncbi.nlm.nih.gov/7595707
https://pubmed.ncbi.nlm.nih.gov/7595707
Autor:
Howard D. Homesley, Irving Shemano, Richard A. Gams, Diane S. Harry, Peter G. Hickox, Robert W. Rebar, Richard C. Bump, Thomas J. Mullin, Anne Colston Wentz, Robert V. OʼToole, Judith V. Lovelace, Carol Lyden
Publikováno v:
American journal of clinical oncology. 16(2)
In this nonblinded, controlled multicenter trial, postmenopausal women were randomly assigned to receive graded doses of toremifene and tamoxifen or no antiestrogen to assess dose-response levels and evaluation methodology. For standardization, trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e0be7c2677221a52eb05eec1f1559
https://pubmed.ncbi.nlm.nih.gov/8452102
https://pubmed.ncbi.nlm.nih.gov/8452102
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 11(2)
PURPOSE To explore further the efficacy of high-dose toremifene in patients with advanced breast cancer who had failed to respond to tamoxifen or whose disease had progressed on tamoxifen. PATIENTS AND METHODS One hundred two perimenopausal or postme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434578013c706afd0c6371949c0b26d5
https://pubmed.ncbi.nlm.nih.gov/8426212
https://pubmed.ncbi.nlm.nih.gov/8426212
Autor:
Irving Shemano, Mark A. Green, John T. Hamm, Douglas C. Tormey, Peter C. Kohler, Daniel G. Haller
Publikováno v:
Journal of Clinical Oncology. 10:674-674
A phase I multicenter evaluation of a novel antiestrogen, toremifene, was undertaken in postmenopausal women with various advanced difficult-to-treat malignancies. One hundred and seven women were treated at one of six dosage levels (10, 20, 40, 60,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6f1acfbe4cb8d487994101a21fba8a
https://doi.org/10.1200/jco.1992.10.4.674
https://doi.org/10.1200/jco.1992.10.4.674
Autor:
Irving Shemano, John T. Hamm, Peter C. Kohler, Michael W. DeGregorio, Douglass C. Tormey, Valerie J. Wiebe
Publikováno v:
Breast Cancer Research and Treatment. 16:S-S
Toremifene is a triphenylethylene derivative structurally and pharmacologically similar to tamoxifen. This Phase I trial assessed the safety, pharmacokinetics, anti-estrogenic, and estrogenic effects of toremifene at six dose levels (10, 20, 40, 60,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa935b459828a8cfcd387f78f397c85
https://doi.org/10.1007/bf01807140
https://doi.org/10.1007/bf01807140
Publikováno v:
Gastrointestinal Radiology. 7:141-147
A double-blind crossover study in 31 normal volunteers showed that intramuscular injection of ceruletide (0.3 microgram/kg) significantly accelerated small bowel transit of barium when compared to placebo. The only adverse effect was frequent pain at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e1580b0fd07821430a4dcb5e8f0e70
https://doi.org/10.1007/bf01887628
https://doi.org/10.1007/bf01887628
Autor:
Mark Nickerson, Irving Shemano
Publikováno v:
Canadian Journal of Biochemistry and Physiology. 36:1243-1249
Thermal responses to a variety of drugs have been investigated at various ambient temperatures, using unanesthetized rats, either lightly restrained or paralyzed with tubocurarine. The results indicate that ambient temperature is a major factor deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76234e5d27b347f52819f4a04b4a967b
https://doi.org/10.1139/o58-135
https://doi.org/10.1139/o58-135
Publikováno v:
Toxicology and Applied Pharmacology. 25:250-258
3,5-Diethylhydantoin (DEH; RMI 36709) consistently prolonged survival of asphyxiated rats after oral or ip administration at doses as low as 12.5 mg/kg. 5,5-Diphenylhydantoin (DPH) was effective when injected ip (50–100 mg/kg) but not after dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ed82a54f04f336ba21cee8244fb20d
https://doi.org/10.1016/s0041-008x(73)80011-0
https://doi.org/10.1016/s0041-008x(73)80011-0
Autor:
Patricia C. Fallon, Irving Shemano
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 103
SummaryL-3,3′,5-Triiodothyronine (T3) potentiated epinephrine-induced contractions of isolated rabbit aortic strip only under the following conditions: 1) copper acetate (2 × 10-7) addition to the bath or 2) when trace metal contaminants were occa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12a90ad683a3d118d97a4cb0cad8e3f
https://pubmed.ncbi.nlm.nih.gov/14445803
https://pubmed.ncbi.nlm.nih.gov/14445803