Zobrazeno 1 - 10
of 1 106
pro vyhledávání: '"Irving L. Weissman"'
Autor:
Satu Strausz, Erik Abner, Grace Blacker, Sarah Galloway, Paige Hansen, Qingying Feng, Brandon T. Lee, Samuel E. Jones, Hele Haapaniemi, Sten Raak, George Ronald Nahass, Erin Sanders, FinnGen, Estonian Genome Centre, Estonian Biobank Research Team, Pilleriin Soodla, Urmo Võsa, Tõnu Esko, Nasa Sinnott-Armstrong, Irving L. Weissman, Mark Daly, Tuomas Aivelo, Michal Caspi Tal, Hanna M. Ollila
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using epidemiological and genetic data from FinnGen and Estonian Biob
Externí odkaz:
https://doaj.org/article/6ff1c773b86b466eacdd4659aaa166eb
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102674- (2023)
Summary: Prospective isolation of defined cell types is critical for the functional study of stem cells, especially in primary human tissues. Here, we present a protocol for purifying 10 transcriptomically and functionally distinct neural stem and pr
Externí odkaz:
https://doaj.org/article/fcc200bd5513479c9874a52abfb3d13d
Autor:
Chiara Anselmi, Federico Caicci, Tommaso Bocci, Matteo Guidetti, Alberto Priori, Veronica Giusti, Tom Levy, Tal Raveh, Ayelet Voskoboynik, Irving L. Weissman, Lucia Manni
Publikováno v:
Cells, Vol 12, Iss 7, p 1041 (2023)
Human neuronal loss occurs through different cellular mechanisms, mainly studied in vitro. Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a life history
Externí odkaz:
https://doaj.org/article/3a3eb11a34e842b78aced2754c51ae47
Autor:
Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implica
Externí odkaz:
https://doaj.org/article/1d0c9d1a12074eb5801bde5c8e5fa9b3
Autor:
Joseph M. McCune, Irving L. Weissman
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 777-786 (2019)
Some have argued that human fetal tissue research is unnecessary and/or immoral. Recently, the Trump administration has taken the drastic––and we believe misguided––step to effectively ban government-funded research on fetal tissue altogether
Externí odkaz:
https://doaj.org/article/fbe151ea49d84e60be71a8ea14ab0cfd
Autor:
Alborz Karimzadeh, Erika S. Varady, Vanessa M. Scarfone, Connie Chao, Karin Grathwohl, Pauline U. Nguyen, Yasamine Ghorbanian, Irving L. Weissman, Thomas Serwold, Matthew A. Inlay
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hematopoietic stem cells (HSCs) are defined by their self-renewal, multipotency, and bone marrow (BM) engraftment abilities. How HSCs emerge during embryonic development remains unclear, but are thought to arise from hemogenic endothelium through an
Externí odkaz:
https://doaj.org/article/8114c91a175f49768b4ae1f22a5838a5
Autor:
Jonathan M. Tsai, Maia Shoham, Nathaniel B. Fernhoff, Benson M. George, Kristopher D. Marjon, Melissa N. McCracken, Kevin S. Kao, Rahul Sinha, Anne Kathrin Volkmer, Masanori Miyanishi, Jun Seita, Yuval Rinkevich, Irving L. Weissman
Publikováno v:
Blood Advances, Vol 3, Iss 18, Pp 2713-2721 (2019)
Peritoneal adhesions are pathological fibroses that ensnare organs after abdominal surgery. This dense connective tissue can cause small bowel obstruction, female infertility, and chronic abdominal pain. The pathogenesis of adhesions is a fibrotic re
Externí odkaz:
https://doaj.org/article/b43ada39bb3b4e929bf7e82a1f6406aa
Autor:
Lara M. Myers, Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Aaron B. Carmody, Ronald J. Messer, Gunsagar Gulati, Ying Ying Yiu, Matthew M. Staron, Cesar Lopez Angel, Rahul Sinha, Maxim Markovic, Edward A. Pham, Benjamin Fram, Aijaz Ahmed, Aaron M. Newman, Jeffrey S. Glenn, Mark M. Davis, Susan M. Kaech, Irving L. Weissman, Kim J. Hasenkrug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune
Externí odkaz:
https://doaj.org/article/1fe7158a38ec4c6c9bd116baa3bb1dee
Autor:
Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Lara Myers, Lamin B. Cham, Katrin D. Mayer-Barber, Andrea C. Bohrer, Ehydel Castro, Ying Ying Yiu, Cesar Lopez Angel, Ed Pham, Aaron B. Carmody, Ronald J. Messer, Eric Gars, Jens Kortmann, Maxim Markovic, Michaela Hasenkrug, Karin E. Peterson, Clayton W. Winkler, Tyson A. Woods, Paige Hansen, Sarah Galloway, Dhananjay Wagh, Benjamin J. Fram, Thai Nguyen, Daniel Corey, Raja Sab Kalluru, Niaz Banaei, Jayakumar Rajadas, Denise M. Monack, Aijaz Ahmed, Debashis Sahoo, Mark M. Davis, Jeffrey S. Glenn, Tom Adomati, Karl S. Lang, Irving L. Weissman, Kim J. Hasenkrug
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive compon
Externí odkaz:
https://doaj.org/article/d8f71f31b4e248b893caeb967d0cb234
Autor:
Peter Balogh, Emmalee R. Adelman, John V. Pluvinage, Brian J. Capaldo, Katie C. Freeman, Sandeep Singh, Kamaleldin E. Elagib, Yukio Nakamura, Ryo Kurita, Goro Sashida, Eli R. Zunder, Hui Li, Alejandro A. Gru, Elizabeth A. Price, Stanley L. Schrier, Irving L. Weissman, Maria E. Figueroa, Wendy W. Pang, Adam N. Goldfarb
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
Healthy bone marrow progenitors yield a co-ordinated balance of hematopoietic lineages. This balance shifts with aging toward enhanced granulopoiesis with diminished erythropoiesis and lymphopoiesis, changes which likely contribute to the development
Externí odkaz:
https://doaj.org/article/140cf8159011466eac9107c51977f0f3