Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Irving I. Gottesman"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Oxytocin modulates social behaviours in mammals. Here the authors demonstrate that observational fear, a measure of empathy-like behaviour in rodents, is modulated by oxytocin.
Externí odkaz:
https://doaj.org/article/d58171a7bb1b47278b4bfea522bf9739
Autor:
Naomi R Wray, Irving I Gottesman
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Estimates of heritability of psychiatric disorders quantify the genetic contribution to their etiology. Estimation of these parameters requires affected status on probands and their family members. Traditionally, heritabilities have been estimated fr
Externí odkaz:
https://doaj.org/article/8d49a6e43199414d872fdc029fedb281
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
Empathy is fundamental to human relations, but its neural substrates remain largely unknown. Here we characterize the involvement of oxytocin in the capacity of mice to display emotional state-matching, an empathy-like behavior. When exposed to a fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d0d44ecf07c103bba3342f7838d701
http://link.springer.com/article/10.1038/s41467-017-02279-5
http://link.springer.com/article/10.1038/s41467-017-02279-5
Publikováno v:
Frontiers in Human Neuroscience, Vol 4 (2010)
Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, despite the promising and systematic w
Externí odkaz:
https://doaj.org/article/7270e9ebfc384eebb16917d67d15a006
Autor:
Elizabeth A. Gettig, Vishwajit L. Nimgaonkar, Jonathan Berliner, Triptish Bhatia, Nagendra Narayan Mishra, Irving I. Gottesman, Smita N. Deshpande
Publikováno v:
Asian Journal of Psychiatry. 24:79-84
Schizophrenia (SZ) has an estimated heritability of 64-88%, with the higher values based on twin studies. Conventionally, family history of psychosis is the best individual-level predictor of risk, but reliable risk estimates are unavailable for Indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ef01fa3103ad66d6b911ead44496d
https://doi.org/10.1016/j.ajp.2016.08.015
https://doi.org/10.1016/j.ajp.2016.08.015
The chapter argues that the best evidence supports the contention that psychiatric “conditions” are not discrete “disorders” but rather dimensional and part of the personality sphere. The personality traits that imply dysfunction are positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59540386255637d38dff3bc8b05c5b96
https://doi.org/10.1093/oso/9780198793014.003.0019
https://doi.org/10.1093/oso/9780198793014.003.0019
Autor:
Siddharth Gaikwad, David M. Diamond, Manoj K. Poudel, Cai Song, Jeremy F.P. Ullmann, William H. J. Norton, Matthew O. Parker, Irving I. Gottesman, Judith R. Homberg, Michael Nguyen, Richard E. Brown, Evan J. Kyzar, Raul R. Gainetdinov, Maria Luisa Scattoni, Aleksandra A. Kaluyeva, Allan V. Kalueff, Julian Pittman
Publikováno v:
Homberg, J R, Kyzar, E J, Scattoni, M L, Norton, W H, Pittman, J, Gaikwad, S, Nguyen, M, Poudel, M K, Ullmann, J F P, Diamond, D M, Kaluyeva, A A, Parker, M O, Brown, R E, Song, C, Gainetdinov, R R, Gottesman, I I & Kalueff, A V 2016, ' Genetic and environmental modulation of neurodevelopmental disorders : translational insights from labs to beds ', Brain Research Bulletin, vol. 125, pp. 79-91 . https://doi.org/10.1016/j.brainresbull.2016.04.015
Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06744053df3c7c154f4a899a7e6b36ae
https://doi.org/10.1016/j.brainresbull.2016.04.015
https://doi.org/10.1016/j.brainresbull.2016.04.015
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 63:76-82
One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f37a4313244cb1ea43a43abff3daa2
https://doi.org/10.1016/j.pnpbp.2015.05.004
https://doi.org/10.1016/j.pnpbp.2015.05.004
Autor:
Irving I. Gottesman, Matt McGue
Publikováno v:
Hastings Center Report. 45:S25-S31
Arguably, no psychological variable has received more attention from behavioral geneticists than what has been called "general cognitive ability" (as well as "general intelligence" or "g"), and for good reason. GCA has a rich correlational network, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7057a2358ce17943c1e2c8286d6fe52
https://doi.org/10.1002/hast.495
https://doi.org/10.1002/hast.495