Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Irving H. Goldberg"'
Autor:
Irving H. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 2, Iss 2, Pp 103-109 (1961)
Externí odkaz:
https://doaj.org/article/deb2b683ddf14ca7ada1f1d5762c49b0
Autor:
Amy E. Kallmerten, Lizzy S. Kappen, Ziwei Xiao, Irving H. Goldberg, Graham B. Jones, Yiqing Lin, Dong Ma
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2428-2432
Bulged sites in DNA and RNA have become targets for rational drug design due to their suspected involvement in a number of key biomolecular processes. A lead compound, derived from the enediyne natural product NCS-chrom has been used to inform chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef360bb840b5afbf3985e9f5c2d1a993
https://doi.org/10.1016/j.bmc.2009.02.005
https://doi.org/10.1016/j.bmc.2009.02.005
Autor:
Ziwei Xiao, Dong Ma, Geum-Sook Hwang, Irving H. Goldberg, Graham B. Jones, Yiqing Lin, Lizzy S. Kappen
Publikováno v:
Current Topics in Medicinal Chemistry. 8:436-447
Of the commonly recognized structural elements within nucleic acids, bulges are among the least developed as targets for small molecules. Bulges in DNA and RNA have been linked to biomolecular processes involved in numerous diseases, thus probes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01fcae0fa13e8bd7858dc0044d4e00f
https://doi.org/10.2174/156802608783955692
https://doi.org/10.2174/156802608783955692
Publikováno v:
Biochemistry. 46:4793-4803
The solution structure of the complex formed between an oligodeoxynucleotide containing a two-base bulge (5'-CCATCGTCTACCTTTGGTAGGATGG) and SCA-alpha2, a designed spirocyclic helical molecule, has been elucidated. SCA-alpha2, a close mimic of the met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde3b55c8fc44812035b04632710326e
https://doi.org/10.1021/bi602599d
https://doi.org/10.1021/bi602599d
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2895-2899
NCSi-gb is a neocarzinostatin chromophore (NCS-chrom) metabolite which binds strongly to certain two-base DNA bulges. Compared with previously reported NCSi-gb analogues, a new analogue with a different aminoglycoside position was synthesized, and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82287f2c298f6e0c86f4d1f453c998d
https://doi.org/10.1016/j.bmcl.2006.03.006
https://doi.org/10.1016/j.bmcl.2006.03.006
Publikováno v:
Biochemistry. 43:641-650
The solution structure of the complex formed between an oligonucleotide containing a two-base bulge (5'-CACGCAGTTCGGAC.5'-GTCCGATGCGTG) and ent-DDI, a designed synthetic agent, has been elucidated using high-resolution NMR spectroscopy and restrained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5686bb62a28749baea78ea2600283ab
https://doi.org/10.1021/bi035824i
https://doi.org/10.1021/bi035824i
Publikováno v:
Biochemistry. 42:1186-1198
Neocarzinostatin (NCS-chrom), a natural enediyne antitumor antibiotic, undergoes either thiol-dependent or thiol-independent activation, resulting in distinctly different DNA cleavage patterns. Structures of two different post-activated NCS-chrom com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc1a859e18a817a9c08c34006a4f391
https://doi.org/10.1021/bi0206210
https://doi.org/10.1021/bi0206210
Autor:
Irving H. Goldberg, Geum-Sook Hwang, Graham B. Jones, Farid S. Fouad, William T. Pennington, Ghassan Qabaja, Jeffrey L. Harris, Zhen Xi, Justin M. Wright
Publikováno v:
Chemistry & Biology. 9(8):925-931
Bulged regions of nucleic acids are important structural motifs whose function has been linked to a number of key nuclear processes. Additionally, bulged intermediates have been implicated in the etiology of several genetic diseases and as targets fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc83897728dc5b4f1f6ee8bcc16bc96
Publikováno v:
Biochemistry. 40:15378-15383
Neocarzinostatin chromophore (NCS-Chrom) induces strong cleavage at a single site (C3) in the single-stranded and 5' (32)P-end-labeled 13-mer GCCAGATTTGAGC in a reaction dependent on a thiol. By contrast, in the duplex form of the same 13-mer, strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17b7fa9862e2d6666d6c9193f8c1245
https://doi.org/10.1021/bi011647e
https://doi.org/10.1021/bi011647e