Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Irving Boime"'
Autor:
Albina Jablonka-Shariff, Irving Boime
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65002 (2013)
The coordinated secretion of LH and FSH are critical for reproductive functions. After translocation into the endoplasmic reticulum (ER), their biosynthetic routes diverge at a determinative step prior to sorting in the regulated (LH) and constitutiv
Externí odkaz:
https://doaj.org/article/4636037d2a3f45598904f0bc8d8b99ed
Autor:
Melissa Larson, Huizhen Wang, Christopher A. Pearl, P. Michael Conn, Irving Boime, Albina Jablonka-Shariff, T. Rajendra Kumar, William L. Miller
Publikováno v:
Proceedings of the National Academy of Sciences. 111:5735-5740
FSH and luteinizing hormone (LH) are secreted constitutively or in pulses, respectively, from pituitary gonadotropes in many vertebrates, and regulate ovarian function. The molecular basis for this evolutionarily conserved gonadotropin-specific secre
Publikováno v:
Endocrinology. 151:388-393
LH and FSH are produced by the same gonadotrope cells of the anterior pituitary but differ in their mode of secretion. This coordinated secretion of LH and FSH is essential for normal follicular development and ovulation in females and for spermatoge
Autor:
Irving Boime, Christopher A. Pearl
Publikováno v:
Molecular and Cellular Endocrinology. 309:76-81
LH and FSH are produced by the same gonadotrope cells of the anterior pituitary but differ in their mode of secretion. LH secretion is primarily episodic, or regulated, while FSH secretion is primarily basal, or constitutive. The asparagine (N)-linke
Autor:
Irving Boime, Albina Jablonka-Shariff
Publikováno v:
Molecular Endocrinology. 23:316-323
Although the LHbeta- and chorionic gonadotropin-beta- (CGbeta) subunits share a high degree of sequence identity (>85%) in the first 114 amino acids, there is considerable sequence divergence at their carboxy ends. The CGbeta-subunit terminates with
Autor:
T E Adams, Irving Boime
Publikováno v:
Reproduction in Domestic Animals. 43:186-192
Using recombinant gonadotropins for assisted reproduction of domestic species is still in its infancy. Yet, the purity, potency and pathogen-free nature of recombinant gonadotropins make them attractive alternatives to tissue-derived gonadotropic age
Publikováno v:
Molecular Endocrinology. 21:1670-1684
The biosynthetic pathway governing inhibin heterodimer (alpha/beta) and activin homodimer (beta/beta) assembly and secretion from ovarian granulosa cells is not fully understood. Here, we examined the role of inhibin subunit glycosylation in the asse
Publikováno v:
Molecular Endocrinology. 20:1437-1446
The human glycoprotein hormones chorionic gonadotropin (CG), TSH, LH, and FSH are heterodimers composed of a common alpha-subunit and a hormone-specific beta-subunit. The subunits assemble noncovalently early in the secretory pathway. LH and FSH are
Autor:
Malgorzata Bielinska, Irving Boime, Elena Genova, David B. Wilson, Helka Parviainen, Nafis A. Rahman, Sanne Kiiveri, Markku Heikinheimo, Juhani Leppäluoto
Publikováno v:
Endocrinology. 146:3975-3984
In response to prepubertal gonadectomy certain inbred mouse strains, including DBA/2J, develop sex steroid-producing adrenocortical neoplasms. This phenomenon has been attributed to a lack of gonadal hormones or a compensatory increase in gonadotropi
Publikováno v:
Biology of Reproduction. 72:301-308
We previously demonstrated that genetically linking one or more of the glycoprotein hormone-specific β subunit genes to the common α subunit resulted in single-chain analogues that were bioactive in vitro. The ability of such large structures to bi