Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Irvin Winkler"'
Autor:
Thomas C. Merigan, A Dunkler, Jan Balzarini, D Oette, J P Kleim, Irvin Winkler, J R Suarez, Mark A. Winters, Gunther Riess
Publikováno v:
The Journal of Infectious Diseases. 179:709-713
The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation
Autor:
Edward Arnold, Gunther Riess, Stephen H. Hughes, Irvin Winkler, Y. Hsiou, Arthur D. Clark, Manfred Rösner, Jianping Ding, Kalyan Das, Jörg Peter Kleim
Publikováno v:
Journal of Molecular Biology. 284:313-323
The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 ( S -4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroqui noxalin-2(1 H )-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 i
Autor:
Gunther Riess, Erik De Ckrcq, Heidi Pelemans, Irvin Winkler, Jörg-Peter Kleim, Jan Balzarini, Manfred Dr Roesner
Publikováno v:
Biochemical Pharmacology. 55:617-625
An azidothymidine (AZT)-resistant virus strain (HIV-1/AZT) (containing the 67 Asp → Asn, 70 Lys → Arg, 215 Thr → Phe and 219 Lys → Gln mutations into its reverse transcriptase) was grown in the combined presence of 2′,3t - dideoxy-3′-thia
Autor:
Irvin Winkler, M. Roesner, Heidi Pelemans, Jan Balzarini, J P Kleim, E. De Clercq, Gunther Riess
Publikováno v:
The Journal of Infectious Diseases. 176:1392-1397
Replication of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) strains (containing the 41 Met-->Leu and 215 Thr-->Tyr mutations in reverse transcriptase [RT]) was inhibited to a significantly greater extent by the combination of lami
Autor:
Czechtizky Werngard, Raisa Nagorny, Zhongli Gao, Hendrix James A, Siegfried Stengelin, Lothar Schwink, Pascal George, Marie-Pierre Pruniaux, Lei Tang, Irvin Winkler, Juan Antonio Sánchez, Ulrike Lukasczyk, Etienne Guillot, Hurst William J
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(11)
A novel series of histamine H3 receptor (H3R) antagonists was derived from an arylurea lead series (1) via bioisosteric replacement of the urea functionality by an amide linkage. The arylamide series was optimized through SAR studies by a broad varia
Autor:
Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:34-38
The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat
Autor:
Gerhard Jähne, Otto Holzhäuser, Irvin Winkler, Günther Rieß, Herbert Kroha, Matthias Helsberg, Manfred Rösner, Armin Müller, Christoph Dr Meichsner
Publikováno v:
Tetrahedron Letters. 33:5335-5338
A versatile and high-yielding synthesis of racemic carbocyclic phosphonate nucleosides of adenine, hypoxanthine, guanine, cytosine, uracil, and thymine has been developed. These newly prepared compounds are isosteric (and isoelectronic) with (carbo)c
Autor:
Gerhard H. Schmidt, Irvin Winkler
Publikováno v:
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 98:471-487
1. 1. Under laboratory conditions it was possible to receive w- and s-eggs from queens of Formica polyctena (Foerster) in such large numbers that their RNA patterns could be compared during the whole embryonic development. 2. 2. The RNA amount was hi
Autor:
Dieter Kreusel, Stefan Toemoe, Irvin Winkler, Lars Greiffenberg, Yannick Wurm, Marion Zerlin, Jens Martin, Laszlo Ballabas
Publikováno v:
Animal Cell Technology Meets Genomics ISBN: 9781402027918
During the last years the requirements on modern cell culture have rapidly increased, comprising quality control, global administration and global availability of cell lines. To meet these demands we developed CryoStock as a new software tool for cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14609d9c161c5674605732b22e16c87f
https://doi.org/10.1007/1-4020-3103-3_79
https://doi.org/10.1007/1-4020-3103-3_79
Autor:
Gerhard Jähne, Matthias Helsberg, Irvin Winkler, Gerhard Gross, Armin Müller, Thomas Scholl, Herbert Kroha
Publikováno v:
Angewandte Chemie. 106:603-605