Výsledky vyhledávání - "Iruthayaraj, Ancy"

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Akademický článek

Investigation about the Inhibition of HIV-1 Gp41 Fusion via Andrographis Paniculata: Virtual Screening, Molecular Dynamics Simulation and Free Energy Calculation.

Autor: Iruthayaraj, Ancy¹, Kumaradhas, Poomani¹ kumaradhas@yahoo.com

Publikováno v: American Journal of Biomedical Sciences. 2020, Vol. 12 Issue 3, p191-205. 15p.

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Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations

Autor: Ramakrishnan, Jaganathan, Kandasamy, Saravanan, Iruthayaraj, Ancy, Magudeeswaran, Sivanandam, Chinnasamy, Kalaiarasi, Poomani, Kumaradhas

Publikováno v: Applied Biochemistry and Biotechnology

The unprecedented coronavirus SARS-CoV-2 outbreak at Wuhan, China, caused acute respiratory infection to humans. There is no precise vaccine/therapeutic agents available to combat the COVID-19 disease. Some repurposed drugs are saving the life of dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1f6bda26c5bb5228291cf9ed3287eb
https://doi.org/10.1007/s12010-020-03475-8

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Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS-CoV-2 main protease: a molecular docking, molecular dynamics and binding free energy simulation study

Autor: Iruthayaraj Ancy, Poomani Kumaradhas, Mugudeeswaran Sivanandam

Publikováno v: Journal of Biomolecular Structure and Dynamics
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record

Initially, the SARS-CoV-2 virus was emerged from Wuhan, China and rapidly spreading across the world and urges the scientific community to develop antiviral therapeutic agents. Among several strategies, drug repurposing will help to react immediately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276045c2f342ecc566d998c9b3394fa9

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Insights of inhibition mechanism of sifuvirtide and MT-sifuvirtide against wild and mutant HIV-1 envelope glycoprotein41: a molecular dynamics simulation and binding free energy study

Autor: Raju Kalaivani, Poomani Kumaradhas, Iruthayaraj Ancy, Magudeeswaran Sivanandam

Sifuvirtide (SFT) is the second generation inhibitor of HIV-1 gp41 fusion protein, which is under phase III clinical trial for anti-HIV. However, over a period of time virus develops resistance against SFT. To overcome resistance, methionine and thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eec06fc08307eb77f33a6f1dc6aedf

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Novel antioxidant astaxanthin-s-allyl cysteine biconjugate diminished oxidative stress and mitochondrial dysfunction to triumph diabetes in rat model

Autor: Loganathan Chitra, Poomani Kumaradhas, Iruthayaraj Ancy, Thayumanavan Palvannan, Sakayanathan Penislusshiyan

Publikováno v: Life Sciences. 245:117367

Aims The present study determines the effect of administration of novel antioxidant astaxanthin-s-allyl cysteine biconjugate (AST-SAC) against streptozotocin-induced diabetes mellitus (DM) in rats. Main methods AST-SAC (1 mg/kg/day) was treated again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635e9a8ea3ce03fcafc2aaae51f69e44
https://doi.org/10.1016/j.lfs.2020.117367

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