Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response

Autor: Suzanne Miller, Iain D Stewart, Debbie Clements, Irshad Soomro, Roya Babaei‐Jadidi, Simon R Johnson

Publikováno v: The Journal of Pathology: Clinical Research, Vol 6, Iss 3, Pp 215-226 (2020)

Abstract Lymphangioleiomyomatosis (LAM) is a rare multisystem disease with a variable clinical course. The lungs are infiltrated by nodules of LAM cells, stromal cells and inflammatory cells, causing lung cysts and respiratory failure. We used immuno

Externí odkaz: https://doaj.org/article/b9717dd632cc47e1b0448cf968fea92f

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Autor: Simon L. Parsons, Monika Tripathi, Vijayendran Sujendran, E. Fidziukiewicz, Jim Davies, Ula Mahadeva, Annalise Katz-Summercorn, Neil A. Shepherd, A. Northrop, Simon Tavaré, James A. Gossage, Richard Berrisford, S Lishman, Michael F. Scott, Shaun R. Preston, W. Fickling, Andrew Hindmarsh, Jesper Lagergren, Juliane Perner, Peter Safranek, Hugh Barr, Grant Sanders, Francesca D. Ciccarelli, Xiaodun Li, D. Khoo, Paw Edwards, Helen G. Coleman, Timothy J. Underwood, Christopher J. Peters, D. Loureda, Ayesha Noorani, Laszlo Igali, Maria Secrier, Bhaskar Kumar, Ahmad Miremadi, Irshad Soomro, Wais Habib, Andrew Davies, George B. Hanna, Izhar Bagwan, Matthew D. Eldridge, Andy G. Lynch, S Suortamo, Rehan Haidry, Fuju Chang, Ginny Devonshire, John H. Saunders, Nick Carroll, Michael P. Lewis, Sonia Puig, Stephen J. Hayes, Charles Crichton, Olga Tucker, Sharmila Sothi, Christopher C.W. Hughes, Andrew D Beggs, R. de la Rue, J Zylstra, J. R. O'Neill, Vicki Save, Yeng Ang, Robert C. Walker, E Cheong, Krishna Moorthy, Laurence Lovat, Vicky Goh, Richard J E Skipworth, Richard C. Turkington, S Oakes, Gianmarco Contino, Sriganesh Jammula, R Bott, M O'Donovan, O Old, B Grace, Ricardo McEwen, C Harden, Barbara Nutzinger, Philippe Taniere, Rebecca C. Fitzgerald, Ben E. Byrne, Shalini Malhotra, Nicola Grehan, Damian T. McManus, Anna M. Grabowska, Andrew D. Sharrocks, Sujath Abbas, William R. C. Knight, Shona MacRae, Philip Kaye, Ted R. Hupp

Publikováno v: European Journal of Surgical Oncology. 46:2257-2261

Prognostication in oesophageal cancer on the basis of preoperative variables is challenging. Many of the accepted predictors of survival are only derived after surgical treatment and may be influenced by neoadjuvant therapy. This study aims to explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777069ab22a8ac8baa5c4506d8ef9ddb
https://doi.org/10.1016/j.ejso.2020.07.003

Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response

Autor: Iain A. Stewart, Suzanne Miller, Debbie Clements, Irshad Soomro, Simon R. Johnson, Roya Babaei-Jadidi

Publikováno v: The Journal of Pathology: Clinical Research
The Journal of Pathology: Clinical Research, Vol 6, Iss 3, Pp 215-226 (2020)

Lymphangioleiomyomatosis (LAM) is a rare multisystem disease with a variable clinical course. The lungs are infiltrated by nodules of LAM cells, stromal cells and inflammatory cells, causing lung cysts and respiratory failure. We used immunohistochem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b258740540c1fea1e89e227dda3471f3
https://doi.org/10.1002/cjp2.162

Identification of subtypes of Barrett's esophagus and esophageal adenocarcinoma based on DNA methylation profiles and integration of transcriptome and genome data

Autor: Timothy J. Underwood, Sujath Abbas, Rachel de la Rue, Jason Crawte, Juliane Perner, Richard C. Turkington, Paul A.W. Edwards, Sriganesh Jammula, Fergus Noble, Hugh Barr, Andy G. Lynch, Sari Suortamo, Catherine Harden, Vijayendran Sujendran, Maria Secrier, Sonia Puig, Sarah Oakes, Francesca D. Ciccarelli, Daniele Biasci, Monika Tripathi, Peter Safranek, Krishna Moorthy, Jim Davies, Constanza Linossi, Ula Mahadeva, Jan Bornschein, Richard Berrisford, Ted R. Hupp, Shaun R. Preston, Ayesha Noorani, Xiaodun Li, Michael Scott, Barbara Nutzinger, Annalise Katz-Summercorn, Neil A. Shepherd, Elwira Fidziukiewicz, Charles Crichton, Philippe Taniere, Adrienn Blasko, Amber Grantham, John H. Saunders, Michael P. Lewis, Caitriona Hughes, Ahmad Miremadi, Grant Sanders, Andrew D Beggs, Sharmila Sothi, Shona MacRae, Simon Tavaré, Ginny Devonshire, Sarah Killcoyne, Lawrence Bower, Christopher J. Peters, James A. Gossage, Shalini Malhotra, Laszlo Igali, Suzy Lishman, Philip Kaye, Simon L. Parsons, Alex Northrop, J. Robert O’Neill, Gianmarco Contino, Nicola Grehan, Maria O'Donovan, Olga Tucker, Elizabeth C Smyth, Yeng Ang, Irshad Soomro, Vinod V. Subash, Andrew Hindmarsh, Jesper Lagergren, Anna M. Grabowska, Izhar Bagwan, Andrew Davies, Rehan Haidry, Fuju Chang, Bhaskar Kumar, Jack Owsley, Rebecca C. Fitzgerald, Laurence Lovat, George B. Hanna, Matthew D. Eldridge, Stephen J. Hayes, J Zylstra, Vicky Goh, Richard J E Skipworth, Nick Carroll, Matthew Eldridge, Vicki Save, Ed Cheong, Filip Wronowski, Oliver Old

Publikováno v: Gastroenterology

BACKGROUND & AIMS: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about epigenetic alterations. We perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912ceba758732d6d4584fa90151642b0
https://eprints.soton.ac.uk/441229/

Postoperative survival following perioperative MAGIC versus neoadjuvant OE02-type chemotherapy in oesophageal adenocarcinoma

Autor: N.T. Welch, John H. Saunders, Alex M. Reece-Smith, C R Bowman, Srinivasan Madhusudan, Philip Kaye, John P. Duffy, Simon L. Parsons, Irshad Soomro

Publikováno v: The Annals of The Royal College of Surgeons of England. 99:378-384

The optimal management of resectable oesophageal adenocarcinoma is controversial, with many centres using neoadjuvant chemotherapy following the Medical Research Council (MRC) oesophageal working group (OE02) trial and the MRC Adjuvant Gastric Infusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe86a6f3fea28dcc3a415386e31677b
https://doi.org/10.1308/rcsann.2017.0024