Tumor-associated macrophages restrict CD8 ⁺ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.

Autor: Tharp KM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Kersten K; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA., Maller O; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Timblin GA; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Stashko C; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Canale FP; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Menjivar RE; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Hayward MK; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Berestjuk I; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Ten Hoeve J; UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA., Samad B; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA., Ironside AJ; Department of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK., di Magliano MP; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA., Muir A; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., Geiger R; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Combes AJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; ImmunoX Initiative, University of California San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Weaver VM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and The Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.

Publikováno v: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1045-1062. Date of Electronic Publication: 2024 Jun 03.

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.

Autor: Stashko C; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA., Hayward MK; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA., Northey JJ; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA., Pearson N; Harvey Mudd College, Claremont, CA, USA., Ironside AJ; Department of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK., Lakins JN; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA., Oria R; Department of Surgery, University of California, San Francisco, CA, USA.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA., Goyette MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Mayo L; Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA., Russnes HG; Department of Pathology and Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Hwang ES; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Kutys ML; Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.; UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weaver VM; Department of Surgery, University of California, San Francisco, CA, USA. valerie.weaver@ucsf.edu.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.; UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.; Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jun 15; Vol. 14 (1), pp. 3561. Date of Electronic Publication: 2023 Jun 15.

Derivation of a nuclear heterogeneity image index to grade DCIS.

Autor: Hayward MK; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Louise Jones J; Center for Tumor Biology, Barts Cancer Institute, John Vane Science Building, Barts and the London School of Medicine and Dentistry, UK., Hall A; Department of Pathology, Duke University Medical Center, Durham, NC, USA., King L; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Ironside AJ; Department of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK., Nelson AC; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Shelley Hwang E; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Weaver VM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and The Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2020 Dec 03; Vol. 18, pp. 4063-4070. Date of Electronic Publication: 2020 Dec 03 (Print Publication: 2020).