The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity

Autor: Kathleen Gürtler, Hyun-Jung An, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Andriy V. Kubarenko, Lutz Hamann, Ralf R. Schumann, Anke van der Ploeg, Djin-Ye Oh, Young Jong Kim, Saubashya Sur, Oliver Kumpf, Jie-Oh Lee, Jana Eckert, Alexander N.R. Weber, Jung I. Kim, Linn Lundvall, Michael Kabesch

Publikováno v: Immunity, 39, 4, pp. 647-60
Immunity, 39, 647-60

Item does not contain fulltext Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that initiates an immune response after recognition of bacterial LPS. Here, we report the crystal structure of murine LBP at 2.9 A resolution. Sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989b858b55f926aa6fb9c5e0e2ea8b84
https://doi.org/10.1016/j.immuni.2013.09.005

SMIM1 underlies the Vel blood group and influences red blood cell traits

Autor: Dorine W. Swinkels, Heather Lloyd-Jones, Hendrik G. Stunnenberg, Graham Kiddle, Hindrik H. D. Kerstens, Gregory E. Jordan, Lonneke Haer-Wigman, Rudolf S N Fehrmann, Juha Karjalainen, Herman H W Silljé, Peter A. Smethurst, Cornelis A. Albers, Harm-Jan Westra, Hein Schepers, Jonathan Stephens, J. Poole, Willem H. Ouwehand, Mattia Frontini, Derek L. Stemple, Nicole Soranzo, Nicholas A. Watkins, Niek Verweij, Samantha Farrow, Augusto Rendon, Emile van den Akker, Vincent G. Haver, Alan Gray, C. Ellen van der Schoot, Ana Cvejic, Jennifer G. Sambrook, Myrto Kostadima, Nick Goldman, Ewa Bielczyk-Maczyńska, Botond Sipos, Malcolm Needs, Asif U. Tamuri, Aicha Ait Soussan, Lude Franke, Klaus Rieneck, Paul Bertone, Pim van der Harst, Masja de Haas

Publikováno v: Nature Genetics; Vol 45
Nature Genetics, 45, 5, pp. 542-5
Nature Genetics, 45(5), 542-545. Nature Publishing Group
Nature genetics, 45(5), 542-545. Nature Publishing Group
Nature Genetics, 45, 542-5

The blood group Vel was discovered 60 years ago(1), but the underlying gene is unknown. Individuals negative for the Vel antigen are rare and are required for the safe transfusion of patients with antibodies to Vel(2). To identify the responsible gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd000f2b294621e1e8bdd2f7d055d50
https://hdl.handle.net/11370/51bc8bbb-6eec-46d4-83fc-611fb472bc73

Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients

Autor: Michiel L. Bots, Jack F.M. Wetzels, Piet M. ter Wee, Dorine W. Swinkels, Menso J. Nubé, Contrast investigators, Erwin T. Wiegerinck, E. Lars Penne, Claire H. den Hoedt, Albert H.A. Mazairac, Neelke C. van der Weerd, Peter J. Blankestijn, Marinus A. van den Dorpel, Muriel P.C. Grooteman

Publikováno v: Nephrology, Dialysis, Transplantation, 28(12), 3062-3071. Oxford University Press
van der Weerd, N C, Grooteman, M P C, Bots, M L, van den Dorpel, M A, den Hoedt, C H, Mazairac, A H A, Nube, M J, Penne, E L, Wetzels, J F, Wiegerinck, E T, Swinkels, D W, Blankestijn, P J & ter Wee, P M 2013, ' Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients ', Nephrology, Dialysis, Transplantation, vol. 28, no. 12, pp. 3062-3071 . https://doi.org/10.1093/ndt/gfs488
Nephrology, Dialysis, Transplantation, 28, 12, pp. 3062-71
Nephrology, Dialysis, Transplantation, 28, 3062-71

Item does not contain fulltext BACKGROUND: The development of atherosclerosis may be enhanced by iron accumulation in macrophages. Hepcidin-25 is a key regulator of iron homeostasis, which downregulates the cellular iron exporter ferroportin. In haem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e009c6df9cde5c792b385838ad91d571
https://doi.org/10.1093/ndt/gfs488

The iron link between malaria and invasive non-typhoid Salmonella infections

Autor: Dorine W. Swinkels, Susanne van Santen, André J. A. M. van der Ven, Quirijn de Mast

Publikováno v: Trends in Parasitology, 29, 5, pp. 220-7
Trends in Parasitology, 29, 220-7

Item does not contain fulltext Epidemiological studies have demonstrated an association between malaria and invasive non-typhoid Salmonella (NTS) infections, especially in children. We explore the role of iron as a possible cofactor in this associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cca6c919d7177beb4182ff071ef854c
https://doi.org/10.1016/j.pt.2013.03.006

High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobin

Autor: Baart, A.M., Noord, P.A.H. van, Vergouwe, Y., Moons, K.G., Swinkels, D.W., Wiegerinck, E.T.G., Kort, W.L. de, Atsma, F.

Publikováno v: Transfusion, 53, 1670-7
Transfusion, 53, 8, pp. 1670-7

Item does not contain fulltext BACKGROUND: Blood donors that meet the hemoglobin (Hb) criteria for donation may have undetected subclinical iron deficiency. The aim of this study was to assess the prevalence of subclinical iron deficiency in whole bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ceb691441cd7e3382963a0d8f4625b10
https://doi.org/10.1111/j.1537-2995.2012.03956.x