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Akademický článek

Synthesis of a Borrelia burgdorferi-Derived Muropeptide Standard Fragment Library

Autor: Rachel Putnik, Junhui Zhou, Irnov Irnov, Elise Garner, Min Liu, Klare L. Bersch, Christine Jacobs-Wagner, Catherine Leimkuhler Grimes

Publikováno v: Molecules, Vol 29, Iss 14, p 3297 (2024)

The interplay between the human innate immune system and bacterial cell wall components is pivotal in understanding diseases such as Crohn’s disease and Lyme arthritis. Lyme disease, caused by Borrelia burgdorferi, is the most prevalent tick-borne

Externí odkaz: https://doaj.org/article/18ffb0cf8daa4a49bd6f34cab08605e7

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Akademický článek

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

Autor: Constantin N. Takacs, Jenny Wachter, Yingjie Xiang, Zhongqing Ren, Xheni Karaboja, Molly Scott, Matthew R. Stoner, Irnov Irnov, Nicholas Jannetty, Patricia A. Rosa, Xindan Wang, Christine Jacobs-Wagner

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Abstract Borrelia burgdorferi, the tick-transmitted spirochete agent of Lyme disease, has a highly segmented genome with a linear chromosome and various linear or circular plasmids. Here, by imaging several chromosomal loci and 16 distinct plasmids,

Externí odkaz: https://doaj.org/article/66f28c58de054aff8c081f7314216b73

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Akademický článek

Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events in Escherichia coli

Autor: Manuel Campos, Sander K Govers, Irnov Irnov, Genevieve S Dobihal, François Cornet, Christine Jacobs‐Wagner

Publikováno v: Molecular Systems Biology, Vol 14, Iss 6, Pp 1-21 (2018)

Abstract Cell size, cell growth, and cell cycle events are necessarily intertwined to achieve robust bacterial replication. Yet, a comprehensive and integrated view of these fundamental processes is lacking. Here, we describe an image‐based quantit

Externí odkaz: https://doaj.org/article/94bfc580482c44cb9cc54078279fe652

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Akademický článek

4165 Mechanisms of Prophage-Mediated Virulence Driving Community-Acquired MRSA Contagion

Autor: Robert James Ulrich, Irnov Irnov, William Sause, Magdelena Podkowik, Victor Torres, Bo Shopsin

Publikováno v: Journal of Clinical and Translational Science, Vol 4, Pp 11-12 (2020)

OBJECTIVES/GOALS: We recently identified a CA-MRSA strain in Brooklyn, New York (USA300-BKV) causing an outbreak of severe skin infections in predominantly healthy children. The evolution of USA300-BKV included acquisition of a novel prophage, and ou

Externí odkaz: https://doaj.org/article/48028eeb443e4f67a14c9b2eee793b43

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Akademický článek

Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate.

Autor: Irnov Irnov, Zhe Wang, Nicholas D Jannetty, Julian A Bustamante, Kyu Y Rhee, Christine Jacobs-Wagner

Publikováno v: PLoS Genetics, Vol 13, Iss 8, p e1006978 (2017)

To achieve robust replication, bacteria must integrate cellular metabolism and cell wall growth. While these two processes have been well characterized, the nature and extent of cross-regulation between them is not well understood. Here, using classi

Externí odkaz: https://doaj.org/article/a68c5e9e95a9453183d34ff14df3bccc

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Akademický článek

Association of RNAs with Bacillus subtilis Hfq.

Autor: Michael Dambach, Irnov Irnov, Wade C Winkler

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55156 (2013)

The prevalence and characteristics of small regulatory RNAs (sRNAs) have not been well characterized for Bacillus subtilis, an important model system for Gram-positive bacteria. However, B. subtilis was recently found to synthesize many candidate sRN

Externí odkaz: https://doaj.org/article/96ad473c7a0846f7914fcea0d527da2c

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