Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Irmgard S. Thorey"'
Autor:
Tatiana Flisikowska, Irmgard S Thorey, Sonja Offner, Francesca Ros, Valeria Lifke, Bryan Zeitler, Oswald Rottmann, Anna Vincent, Lei Zhang, Shirin Jenkins, Helmut Niersbach, Alexander J Kind, Philip D Gregory, Angelika E Schnieke, Josef Platzer
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21045 (2011)
Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and als
Externí odkaz:
https://doaj.org/article/28865b2f7cbb4665ba7b4622b6f2e4fd
Publikováno v:
Journal of Biological Chemistry. 282:6126-6135
Recently we reported a differentiation-dependent inhibition of telomerase activity in human epidermis. Consistent with this observation we found that in keratinocyte cultures calcium-induced differentiation correlates with a decline in telomerase act
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1364
Hapten-binding bispecific antibodies (bsAbs) are effective and versatile tools for targeting diverse payloads, including siRNAs, to specific cells and tissues. In this chapter, we provide examples for successful SiRNA delivery using this powerful tar
Autor:
Katharina Kuhlmeier, Irmgard S. Thorey, Frank Wempe, Katri Koli, Thomas Kirchner, Jürgen Otte, Harald von Melchner, Thorsten Bangsow, Jorma Keski-Oja, Shenchu Jin, Anja Sterner-Kock
Publikováno v:
Genes & Development. 16:2264-2273
Transforming growth factor-βs (TGF-βs) are multifunctional growth factors that are secreted as inactive (latent) precursors in large protein complexes. These complexes include the latency-associated propeptide (LAP) and a latent transforming growth
Autor:
Philippe Bugnon, Johannes Roth, Michaela Bittner, Norman Rieger, Sabine Werner, Jörn-Peter Halle, Alexander Konstantinow, Anja Graf, Silke Durka, Susanne Kaesler, Andreas Goppelt, Eckhard Wolf, Thomas Vogl, Mandy Wöckner, Birgit Reitmaier, Johannes Regenbogen, Irmgard S. Thorey
Publikováno v:
Journal of Biological Chemistry. 276:35818-35825
To gain insight into the molecular mechanisms underlying cutaneous wound repair, we performed a large scale screen to identify novel injury-regulated genes. Here we show a strong up-regulation of the RNA and protein levels of the two Ca(2+)-binding p
Publikováno v:
Developmental Dynamics. 212:277-283
A retroviral gene trap vector (U3Tkneo) that selects for integrations in or near expressed 5′ exons has been used to identify genes that are repressed during hematopoietic differentiation of mouse totipotent embryonic stem cells. The vector contain
Autor:
Roger A. Pedersen, Irmgard S. Thorey, David A. Kulesh, Robert G. Oshima, Nicolay Neznanov, Juanito J. Meneses
Publikováno v:
Developmental Biology. 160:519-534
During embryogenesis, EndoB, the mouse form of human keratin 18 (K18), is expressed in a complex spatial and temporal pattern in various embryonic epithelia. We have compared the expression of transgenic human K18 to the endogenous mouse homolog and
Autor:
Daniela Wenzel, Annette Schmidt, Sabine Werner, Bernd K. Fleischmann, Irmgard S. Thorey, Wilhelm Bloch
Publikováno v:
Endothelium : journal of endothelial cell research. 12(5-6)
Endostatin was suggested to be an antiangiogenic agent with the potential for clinical use in cancer therapy. Unfortunately, up to now no antiangiogenic effect was seen in clinical trials using this substance. The lack of response might be caused by
Autor:
Annette Schmidt, Takako Sasaki, W. Bloch, Irmgard S. Thorey, Rupert Timpl, Daniela Wenzel, Bernd K. Fleischmann, Klaus Addicks, Jürgen Hescheler, Sabine Werner
Publikováno v:
Microvascular research. 71(3)
Endostatin, the proteolytic fragment of collagen XVIII, is known to be a potent inhibitor of angiogenesis. However, to date, only limited knowledge exists with regard to the effects of endostatin on vessel morphology and the underlying signaling path
Autor:
Marie Pierre Manitz, Johannes Roth, Irmgard S. Thorey, Wolfgang Nacken, Matthias Goebeler, Sabine Werner, Rudolf Reichelt, Thomas Vogl, Volker Gerke, Dirk Foell, Clemens Sorg, Anke Strey, Stephan Ludwig
Publikováno v:
Blood. 104(13)
MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major