Kallikrein inhibitors limit kinin B2 antagonist-induced progression of oedematous to haemorrhagic pancreatitis in rats

Autor: Thomas Griesbacher, Irmgard Rainer, Beate Tiran, Bernhard A. Peskar

Publikováno v: British Journal of Pharmacology. 155:865-874

Background and purpose: Exocrine hyperstimulation with caerulein is an established model for oedematous acute pancreatitis. Prevention of oedema formation by bradykinin B2 receptor antagonists induces a progression to a haemorrhagic course in this mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::669868b014f2ddd9a246944381a42a35
https://doi.org/10.1038/bjp.2008.321

9th Meeting of the Spanish Bilio-Pancreatic Club

Autor: A. Okamoto, Paul G. Horgan, Eudaldo M. López-Tomassetti Fernández, Masahiro Hiraoka, Martin E. Fernandez-Zapico, Ryuichiro Doi, Michio Shimizu, Masao Tanaka, H. Guski, Carlos Arroyo Basto, Colin D. Johnson, I. Heukamp, F.A. Wenger, Carlos Fernandez-del Castillo, Janick Selves, N. Egawa, Volkan Adsay, J.I. Gregor, Antonio Martín Malagón, Alexander Schneider, A. Sauvanet, Jean Escourrou, Aysel Ülker, Barbara Bournet, K. Tsuruta, Edward Leen, Numan Cem Balci, Mary E. Money, Göran Mattsson, N. Funata, Michael Portanova Ramirez, Thomas Griesbacher, Metin Basaranoglu, T. Kamisawa, V. Vilgrain, Mehmet Ibis, M. Rodallec, Gwen Lomberk, I. Schimke, A. Couvelard, C. Kiewert, V. Barrau, M. Michael Barmada, Louis Buscail, M.K. Walz, D. O’Toole, Masayuki Imamura, Ömer Faruk Yolcu, Steve R. Gunn, Takashi Sakamoto, Natsuo Oya, C.A. Jacobi, Ömer Başar, Javier Targarona Modena, Vitezslav Kriz, Massimo Falconi, Takashi Mizowaki, David C. Whitcomb, H. Nakajima, M. Kilian, Irmgard Rainer, Yasushi Nagata, Arturo Orellana Vicuna, Clement W. Imrie, Keiko Shibuya, Susan Moug, Seiki Matsuno, Iván Arteaga González, P. Ruszniewski, Hans U. Klor, Miklós Sahin-Tóth, Raul Urrutia, Suresh T. Chari, C.B. Pearce, P. Rufat, A. Ahmed, Engin Uçar, Hermogenes Díaz Luis, Seyfettin Köklü, Erkan Parlak, Koji Fujimoto, Diana Groisman, Anders Danielsson, Ángel Carrillo Pallares, Y. Menu, Koji Yamaguchi, Leif Jansson, Luis Barreda Cevasco, Janette Lamb, Anthony Cuneo, İbrahim Ertuğrul, Per-Ola Carlsson, Kenji Yamao, Edit Szepessy, Patrick Faure, Akos Heinemann

Publikováno v: Pancreatology. 6:33-56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::018c443df6dc5523bcaa8bf965b3536d
https://doi.org/10.1159/000089639

Involvement of tissue kallikrein but not plasma kallikrein in the development of symptoms mediated by endogenous kinins in acute pancreatitis in rats

Autor: Thomas Griesbacher, Beate Tiran, D.Michael Evans, Irmgard Rainer

Publikováno v: British Journal of Pharmacology. 137:692-700

In order to investigate the mechanism of kinin release leading to vascular symptoms in acute interstitial-oedematous pancreatitis, the novel, selective inhibitors of tissue kallikrein, (2S,2′R)-2-(2′-amino-3′-(4′-chlorophenyl)propanoylamino)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4518e8e8993aeb540bd4c51a7e23abe
https://doi.org/10.1038/sj.bjp.0704910

Vespula vulgaris venom: role of kinins and release of 5-hydroxytryptamine from skin mast cells

Autor: Thomas Griesbacher, Fred Lembeck, Stefan Griengl, Petra Althuber, Irmgard Rainer, Marietta Zenz

Publikováno v: European Journal of Pharmacology. 351:95-104

Wasp venoms contain several active components, among them kinin-related peptides. Like bradykinin and [Thr6]bradykinin, Vespula vulgaris venom caused paw oedema following subplantar injection in anaesthetized rats. The oedema was partly inhibited by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ce84fdd49888f3c949a96ff72edef9
https://doi.org/10.1016/s0014-2999(98)00276-3

Inhibition of kinin action and kinin generation compared to dexamethasone pretreatment with respect to vascular effects and pancreatic enzymes in experimental acute pancreatitis

Autor: Thomas Griesbacher, Irmgard Rainer, D.Michael Evans

Publikováno v: Immunopharmacology. 43(2-3)

It was determined earlier that inhibition of the action of endogenous kinins by the bradykinin B2 antagonist, icatibant (Hoe-140; d -Arg-[Hyp3, Thi5, d -Tic7, Oic8]-bradykinin), prevents pancreatic oedema formation during caerulein-induced acute panc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c315207271e5c37c04808bba8725fb57
https://pubmed.ncbi.nlm.nih.gov/10596856