Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Irmgard Kübler"'
Autor:
Maureen J Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Irmgard Kübler, Michael Gersemann, Rachel Cooney, Derek Jewell, Walter Reinisch, Séverine Vermeire, Paul Rutgeerts, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://doaj.org/article/56702dae105843a4a2280f10511cdf3f
Autor:
Maureen J Koslowski, Irmgard Kübler, Mathias Chamaillard, Elke Schaeffeler, Walter Reinisch, Guoxing Wang, Julia Beisner, Alexander Teml, Laurent Peyrin-Biroulet, Stefan Winter, Klaus R Herrlinger, Paul Rutgeerts, Séverine Vermeire, Rachel Cooney, Klaus Fellermann, Derek Jewell, Charles L Bevins, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4496 (2009)
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differe
Externí odkaz:
https://doaj.org/article/6837cf568a854f24b2bbe8a2472f4905
Autor:
Eduard F. Stange, Charles L. Bevins, Guoxing Wang, Robert J. Kays, Jan Wehkamp, Oliver Burk, Klaus Fellermann, Hans Clevers, Alex Gregorieff, Matthias Schwab, Anke Schnabel, Irmgard Kübler, Sabine Nuding
Publikováno v:
The Journal of Immunology. 179:3109-3118
Ileal Crohn′s disease (CD), a chronic mucosal inflammation, is characterized by two pertinent features: a specific decrease of Paneth cell-produced antimicrobial α-defensins and the presence of mucosal-adherent bacteria. A mutation in NOD2, the mu
Autor:
Irmgard Kübler, Michael Gersemann, Svetlana Becker, Julia Beisner, K Rothfuss, Klaus Herrlinger, Klaus Fellermann, Eduard F. Stange, Jan Wehkamp, Maureen J. Koslowski
Publikováno v:
Alimentary pharmacologytherapeutics. 30(6)
Summary Background Crohn’s Disease (CD), a chronic intestinal inflammation, is currently treated primarily by therapeutics which are directed against inflammatory responses. Recent findings though suggest a central role of the innate immune barrier
Autor:
Guoxing Wang, Maureen J. Koslowski, Peter Fritz, Matthias Schwab, Klaus Fellermann, Svetlana Becker, Jan Wehkamp, Irmgard Kübler, Klaus Herrlinger, Eduard F. Stange, Michael Gersemann, Joscha Griger
Publikováno v:
Differentiation; research in biological diversity. 77(1)
Goblet cells are mucin-secreting intestinal cells forming the mucus layer that protects the mucosal surface. Ulcerative colitis (UC) has been associated with a defective colonic mucus layer and a reduced number of goblet cells. In experimental animal
Autor:
Derek P. Jewell, Guoxing Wang, Maureen J. Koslowski, Matthias Schwab, Rachel Cooney, Julia Beisner, Elke Schaeffeler, Zora Teltschik, Eduard F. Stange, Michael Gersemann, Jan Wehkamp, Irmgard Kübler, Paul Rutgeerts, Severine Vermeire, Walter Reinisch
Publikováno v:
Gastroenterology. 142:S-23
Autor:
Severine Vermeire, Guoxing Wang, Derek P. Jewell, Matthias Schwab, Paul Rutgeerts, Michael Gersemann, Elke Schaeffeler, Walter Reinisch, Irmgard Kübler, Maureen J. Koslowski, Eduard F. Stange, Zora Teltschik, Jan Wehkamp, Julia Beisner, Rachel Cooney
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Autor:
Matthias Schwab, Alexander Teml, Julia Beisner, Klaus Fellermann, Paul Rutgeerts, Derek P. Jewell, Elke Schaeffeler, Laurent Peyrin-Biroulet, Klaus Herrlinger, Mathias Chamaillard, Rachel Cooney, Walter Reinisch, Irmgard Kübler, Severine Vermeire, Stefan Winter, Guoxing Wang, Eduard F. Stange, Charles L. Bevins, Maureen J. Koslowski, Jan Wehkamp
Publikováno v:
PLoS ONE
PloS one, vol 4, iss 2
PLoS ONE, Vol 4, Iss 2, p e4496 (2009)
PloS one, vol 4, iss 2
PLoS ONE, Vol 4, Iss 2, p e4496 (2009)
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differe