Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Irmgard Cierny"'
1
Akademický článek
CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment.
Autor: Ulrike Böer, Tahseen Alejel, Stephan Beimesche, Irmgard Cierny, Doris Krause, Willhart Knepel, Gabriele Flügge
Publikováno v: PLoS ONE, Vol 2, Iss 5, p e431 (2007)
BACKGROUND: It has been suggested that stress provokes neuropathological changes and may thus contribute to the precipitation of affective disorders such as depression. Likewise, the pharmacological therapy of depression requires chronic treatment an
Externí odkaz: https://doaj.org/article/b4d03558e7334b3ca6325781d0eec293
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2
A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: Reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice
Autor: Christine Noll, Christoph Hiemke, Ulrike Böer, Irmgard Cierny, Doris Krause, Willhart Knepel
Publikováno v: European Journal of Pharmacology. 633:33-38
The transcription factor CREB regulates adaptive responses like memory consolidation, addiction, and synaptic refinement. Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1839cd82e0933ebfa26ae1d9f48d01
https://doi.org/10.1016/j.ejphar.2010.01.016
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3
Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1β and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells
Autor: C. Schlag, R. Blume, Anna Kutschenko, Elke Oetjen, Willhart Knepel, Roland Stein, Irmgard Cierny, Ralph Krätzner
Publikováno v: Diabetologia. 50:1678-1687
Inappropriate insulin secretion and biosynthesis are hallmarks of beta cell dysfunction and contribute to the progression from a prediabetic state to overt diabetes mellitus. During the prediabetic state, beta cells are exposed to elevated levels of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d141696248415084676cfaae032476a8
https://doi.org/10.1007/s00125-007-0712-2
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4
Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice
Autor: Hongyin Lin, Christoph Hiemke, Annette Heinrich, Willhart Knepel, Georg Mayr, Irmgard Cierny, Doris Krause, Ulrike Böer
Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 33(10)
The molecular mechanism of action of the mood stabilizer lithium is assumed to involve changes in gene expression leading to neuronal adaptation. The transcription factor CREB (cAMP-responsive element binding protein) regulates the expression of many
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8282014f8f06dde982fad662bc8cb7aa
https://pubmed.ncbi.nlm.nih.gov/18046304
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6
Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice
Autor: Stephan Beimesche, Elke Oetjen, Willhart Knepel, Simone Wehner, Irmgard Cierny, Doris Krause, R. Blume, Corinna Dickel, Diana Baun
Publikováno v: Molecular pharmacology. 63(6)
Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. The underlying mechanism is unknown. Previous studies have shown that tacrolimus can inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f462fc5eddefa38a9a7fef7abef1451
https://pubmed.ncbi.nlm.nih.gov/12761338
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7
Tissue-specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6-binding site determined in normal adult tissues in vivo using transgenic mice
Autor: Rafal Grzeskowiak, Andrea Neubauer, Thomas Diedrich, Stephan Beimesche, Tahseen Alejel, Willhart Knepel, Doris Scholz, Stephan Herzig, Irmgard Cierny
Publikováno v: Molecular endocrinology (Baltimore, Md.). 13(5)
A pancreatic islet cell-specific enhancer sequence (PISCES) shared by the rat insulin-I, glucagon, and somatostatin genes binds the paired domain-containing transcription factor Pax6 and confers strong transcriptional activity in pancreatic islet cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9198dae8d21f5d1cbe4facfa58bead75
https://pubmed.ncbi.nlm.nih.gov/10319322
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8
CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment
Autor: Willhart Knepel, Stephan Beimesche, Tahseen Alejel, Ulrike Böer, Gabriele Flügge, Irmgard Cierny, Doris Krause
Publikováno v: PLoS ONE
PLoS ONE, Vol 2, Iss 5, p e431 (2007)
It has been suggested that stress provokes neuropathological changes and may thus contribute to the precipitation of affective disorders such as depression. Likewise, the pharmacological therapy of depression requires chronic treatment and is thought
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab3cf3309f7fa950af815cdc728ac53
https://doi.org/10.1371/journal.pone.0000431
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