Telomere elongation followed by telomere length reduction, in leukocytes from divers exposed to intense oxidative stress – Implications for tissue and organismal aging

Autor: Shalev Itzkovitz, Sara Selig, Liran I. Shlush, Irma Vulto, Karl Skorecki, Ron Berkovitz, Hofit Shachar, Peter M. Lansdorp, Yardena Segev, Yochai Adir, Shiran Yehezkel

Publikováno v: Mechanisms of Ageing and Development. 132:123-130

Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers expose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9464add3791dba15f5c5436bef1528
https://doi.org/10.1016/j.mad.2011.01.005

Telomere Length in Human Natural Killer Cell Subsets

Autor: Irma Vulto, Qin Ouyang, Gabriela M. Baerlocher, Peter M. Lansdorp

Publikováno v: Annals of the New York Academy of Sciences. 1106:240-252

Natural killer (NK) cells are cytotoxic cells that play a critical role in the innate immune response against infections and tumors. In the elderly, the cytotoxic function of NK cells is often compromised. Telomeres progressively shorten with each ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082d24e029c98aed8b6a46083ebbfc0
https://doi.org/10.1196/annals.1392.001

Regulation of Murine Telomere Length by Rtel

Autor: Steven S.S. Poon, Elizabeth A. Chavez, Xiaoli Wu, Irma Vulto, Reza Pourvali, Makoto Kammori, Mike Schertzer, Andras Nagy, Marina Gertsenstein, Peter M. Lansdorp, Hao Ding, Patrick P.L. Tam, Sara Selig

Publikováno v: Cell. 117(7):873-886

Little is known about the genes that regulate telomere length diversity between mammalian species. A candidate gene locus was previously mapped to a region on distal mouse Chr 2q. Within this region, we identified a gene similar to the dog-1 DNA heli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afda181622dd0ef8dd4a2ec2f855b82

Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes

Autor: Gabriela M. Baerlocher, Irma Vulto, Steven S.S. Poon, Geraldine Aubert, Peter M. Lansdorp

Publikováno v: Aubert, Geraldine; Baerlocher, Gabriela M.; Vulto, Irma; Poon, Steven S.; Lansdorp, Peter M. (2012). Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS genetics, 8(5), e1002696. San Francisco, Calif.: Public Library of Science 10.1371/journal.pgen.1002696
PLoS Genetics
PLoS Genetics, Vol 8, Iss 5, p e1002696 (2012)
PLoS genetics, 8(5):e1002696. PUBLIC LIBRARY SCIENCE

Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. We performed a detailed study of the telomere l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bab276fa03e94cba25a1ce98122511
https://boris.unibe.ch/10370/1/journal.pgen.1002696.pdf

Telomere length in Hutchinson-Gilford progeria syndrome

Autor: Michelle L. Decker, Irma Vulto, Elizabeth A. Chavez, Peter M. Lansdorp

Publikováno v: Mechanisms of ageing and development. 130(6)

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous research has shown that the average telomere length in fibroblasts from HG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b36a28e8de1fbffffd8493b0c48e113
https://pubmed.ncbi.nlm.nih.gov/19428457