Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Irma S Lantinga-van Leeuwen"'
Autor:
Lukas J. A. C. Hawinkels, Annemieke van der Wal, Wouter N. Leonhard, Peter ten Dijke, Emile de Heer, Martijn H. Breuning, Dorien J.M. Peters, Irma S Lantinga-van Leeuwen, Sabrine Hassane
Publikováno v:
The Journal of Pathology. 222:21-31
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited renal disease characterized by many fluid-filled cysts and interstitial fibrosis in the kidneys, leading to chronic renal failure. During cystogenesis the renal tubules underg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ab57aea2a7091c7ce266ce6bd330e7
https://doi.org/10.1002/path.2734
https://doi.org/10.1002/path.2734
Autor:
Hester Happé, Wouter N. Leonhard, Dorien J.M. Peters, Irma S. Lantinga-van Leeuwen, Martijn H. Breuning, Annemieke van der Wal, Bob van de Water, Emile de Heer
Publikováno v:
Human Molecular Genetics. 18:2532-2542
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by large fluid-filled cysts and progressive deterioration of renal function necessitating renal replacement therapy. Previously, we generated a tamoxifen-inducible, kidney epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce497bea3118db44b7d5c1360549d9e0
https://doi.org/10.1093/hmg/ddp190
https://doi.org/10.1093/hmg/ddp190
Autor:
Sabrine Hassane, Irma S. Lantinga-van Leeuwen, Dorien J.M. Peters, Martijn H. Breuning, Natascha Van Lent, Nanna Claij, J. Conny van Munsteren, Roeland Hanemaaijer, Marco C. DeRuiter
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:2177-2183
Objective— Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multi-system disorder characterized by progressive cyst formation in the kidneys. Serious complications of ADPKD are intracranial and aortic aneurysms. The condition is mainly cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8826a00d4871d309956df7327fbd5e
https://doi.org/10.1161/atvbaha.107.149252
https://doi.org/10.1161/atvbaha.107.149252
Autor:
Wouter N. Leonhard, Dorien J.M. Peters, Emile de Heer, Annemieke van der Wal, Martijn H. Breuning, Irma S. Lantinga-van Leeuwen
Publikováno v:
Human Molecular Genetics. 16:3188-3196
Autosomal dominant polycystic kidney disease, caused by mutations in the PKD1 gene, is characterized by progressive deterioration of kidney function due to the formation of thousands of cysts leading to kidney failure in mid-life or later. How cysts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c923ad14504020782b6cc4ad219cbc23
https://doi.org/10.1093/hmg/ddm299
https://doi.org/10.1093/hmg/ddm299
Autor:
Dorien J.M. Peters, Sjef Verbeek, Annemieke van de Wal, Wouter N. Leonhard, Martijn H. Breuning, Irma S. Lantinga-van Leeuwen, Emile de Heer
Publikováno v:
genesis. 44:225-232
Gene inactivation often leads to an embryonic-lethal phenotype. In focal diseases like renal cell carcinomas and polycystic kidney disease, somatic gene inactivation in subsets of cells is likely to occur at later stages. We generated a transgenic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf3a881f9599bba9df61a306e151c0f
https://doi.org/10.1002/dvg.20207
https://doi.org/10.1002/dvg.20207
Autor:
Wouter N. Leonhard, Hans G. Dauwerse, Bernard A. van Oost, Hans J. Baelde, Irma S. Lantinga-van Leeuwen, Dorien J.M. Peters, Martijn H. Breuning
Publikováno v:
European Journal of Human Genetics. 13:649-659
The PKD1 and PKD2 genes are mutated in patients with autosomal dominant polycystic kidney disease (ADPKD), a systemic disease, with the formation of renal cysts as main clinical feature. The genes are developmentally regulated and aberrant expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfd5bedbbaf2df9a2978d0f282caa7f
https://doi.org/10.1038/sj.ejhg.5201392
https://doi.org/10.1038/sj.ejhg.5201392
Autor:
Marco C. DeRuiter, Sjef Verbeek, J. G. Dauwerse, Wouter N. Leonhard, Emile de Heer, Hans J. Baelde, Dorien J.M. Peters, Irma S. Lantinga-van Leeuwen, Christopher J. Ward, Annemieke van de Wal, Martijn H. Breuning
Publikováno v:
Human Molecular Genetics. 13:3069-3077
Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of renal failure and is characterized by the formation of many fluid-filled cysts in the kidneys. It is a systemic disorder that is caused by mutations in PKD1 or PKD2. Homozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ce8dc992c674219bcbae174e2a6e19
https://doi.org/10.1093/hmg/ddh336
https://doi.org/10.1093/hmg/ddh336
Publikováno v:
Molecular and Cellular Endocrinology. 197:133-141
The growth hormone (GH) gene is expressed in a variety of tissues outside the pituitary, including the mammary gland. GH expression in the mammary gland is stimulated by progestins. The local synthesis of mammary GH may provide a highly proliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa8fc508a51e24cf0b80ffdf50f0ef9
https://doi.org/10.1016/s0303-7207(02)00257-5
https://doi.org/10.1016/s0303-7207(02)00257-5
Autor:
Sabrine, Hassane, Wouter N, Leonhard, Annemieke, van der Wal, Lukas Jac, Hawinkels, Irma S, Lantinga-van Leeuwen, Peter, ten Dijke, Martijn H, Breuning, Emile, de Heer, Dorien Jm, Peters
Publikováno v:
The Journal of pathology. 222(1)
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited renal disease characterized by many fluid-filled cysts and interstitial fibrosis in the kidneys, leading to chronic renal failure. During cystogenesis the renal tubules underg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2499e7ad06c86f92f0809cbdadd0a27
https://pubmed.ncbi.nlm.nih.gov/20549648
https://pubmed.ncbi.nlm.nih.gov/20549648
Autor:
Martijn H. Breuning, Wouter N. Leonhard, Irma S. Lantinga-van Leeuwen, Dorien J.M. Peters, Jeroen H. Roelfsema
Publikováno v:
BMC Biotechnology, Vol 8, Iss 1, p 18 (2008)
BMC Biotechnology
BMC Biotechnology
Background Inducible conditional knockout animals are widely used to get insight in the function of genes and the pathogenesis of human diseases. These models frequently rely on Cre-mediated recombination of sequences flanked by Lox-P sites. To under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76479bc5bb67a89c4dc6ccfd27fcaa2c
http://www.biomedcentral.com/1472-6750/8/18
http://www.biomedcentral.com/1472-6750/8/18