Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Irma M Gonzales"'
Autor:
Sevtap Savas, David O Azorsa, Hamdi Jarjanazi, Irada Ibrahim-Zada, Irma M Gonzales, Shilpi Arora, Meredith C Henderson, Yun Hee Choi, Laurent Briollais, Hilmi Ozcelik, Sukru Tuzmen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18306 (2011)
Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential chemotherapeutic characteristics in cancer. In this study, we used bioinformatic analysis of pu
Externí odkaz:
https://doaj.org/article/9991665c01a1480dae8f5c82b7e63fe8
Autor:
David O. Azorsa, Spyro Mousses, Daniel D. Von Hoff, Jeffrey M. Trent, Ashish Choudhary, Shilpi Arora, Irma M. Gonzales, Meredith C. Henderson
Supplementary Tables 1-3, Figures 1-4 from High-throughput RNAi Screening Identifies a Role for TNK1 in Growth and Survival of Pancreatic Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8391321645fbb40a7844d70244bec318
https://doi.org/10.1158/1541-7786.22519282.v1
https://doi.org/10.1158/1541-7786.22519282.v1
Autor:
Spyro Mousses, Daniel D. Von Hoff, Irma M. Gonzales, Shilpi Arora, Ashish Choudhary, Jeffrey M. Trent, David O. Azorsa, Meredith C. Henderson
Publikováno v:
Molecular Cancer Research. 9:724-732
To identify novel targets in pancreatic cancer cells, we used high-throughput RNAi (HT-RNAi) to select genes that, when silenced, would decrease viability of pancreatic cancer cells. The HT-RNAi screen involved reverse transfecting the pancreatic can
Autor:
David R Holz, Tobias Zellweger, Martin Oeggerli, Spyro Mousses, Lukas Bubendorf, Heikki Helin, Pasi A. Koivisto, Irma M. Gonzales, Jeff Kiefer, Michael T. Barrett, Sandra Schneider, David O. Azorsa, Christian Ruiz, Alexander Bachmann
Publikováno v:
The Journal of Pathology. 223:543-552
Androgen withdrawal is the standard treatment for advanced prostate cancer. Although this therapy is initially effective, nearly all prostate cancers become refractory to it. Approximately 15% of these castration-resistant prostate cancers harbour a
Autor:
David O. Azorsa, Alexander C. Robeson, Kristen M. Bisanz, Irma M. Gonzales, Christine Kaiser, Shilpi Arora, Joachim Petit, Nathalie Meurice, Christian Beaudry
Publikováno v:
Chemical Biology & Drug Design. 75:360-368
The tumor suppressor gene, SMAD4, is mutated in approximately 30% of colon cancers. To identify compounds with enhanced potency on cells with a SMAD4-negative context, we combined genomic and cheminformatic analyses of publicly available data relatin
Autor:
Raoul Tibes, James L. Slack, James M Bogenberger, Megan E. Buechel, Ruben A. Mesa, R. Tanner Hagelstrom, David O. Azorsa, Hongwei H. Yin, Shilpi Arora, Donald Chow, Esteban Braggio, Tim Demuth, Leena Chaudhuri, Irma M. Gonzales
Publikováno v:
Blood
To identify rational therapeutic combinations with cytarabine (Ara-C), we developed a high-throughput, small-interference RNA (siRNA) platform for myeloid leukemia cells. Of 572 kinases individually silenced in combination with Ara-C, silencing of 10
Autor:
Christian, Ruiz, David R, Holz, Martin, Oeggerli, Sandra, Schneider, Irma M, Gonzales, Jeffrey M, Kiefer, Tobias, Zellweger, Alexander, Bachmann, Pasi A, Koivisto, Heikki J, Helin, Spyro, Mousses, Michael T, Barrett, David O, Azorsa, Lukas, Bubendorf
Publikováno v:
The Journal of pathology. 223(4)
Androgen withdrawal is the standard treatment for advanced prostate cancer. Although this therapy is initially effective, nearly all prostate cancers become refractory to it. Approximately 15% of these castration-resistant prostate cancers harbour a
Autor:
Shilpi Arora, Irma M. Gonzales, R. Tanner Hagelstrom, Ashish Choudhary, Chao Sima, Raoul Tibes, Spyro Mousses, David O. Azorsa, Christian Beaudry
Publikováno v:
Molecular Cancer, Vol 9, Iss 1, p 218 (2010)
Molecular Cancer
Molecular Cancer
Background Ewing's sarcomas are aggressive musculoskeletal tumors occurring most frequently in the long and flat bones as a solitary lesion mostly during the teen-age years of life. With current treatments, significant number of patients relapse and
Autor:
Tanya H. Little, David O. Azorsa, Shilpi Arora, Irma M. Gonzales, R. Tanner Hagelstrom, Robert J. Arceci, Spyro Mousses
Publikováno v:
Cancer Research. 74:3422-3422
Ewing sarcoma is the second most common cancer of bone and soft tissue arising in children and young adults. Standard treatment of Ewing sarcoma includes surgery, radiation, and chemotherapy largely consisting of combinations of non-targeted cytotoxi
Autor:
David O. Azorsa, Richard E. Hayden, Irma M. Gonzales, Devyani Lal, Shilpi Arora, Lydia Young, Sergio S. Cervantes, Rebecca L. McCall, Michael L. Hinni
Publikováno v:
Cancer Research. 72:5136-5136
Objective The prevalence and mortality for head and neck cancer (HNC) has not improved significantly in the last several decades. It is the sixth most common cancer with an estimated 600,000 new cases diagnosed worldwide every year and has ∼50% 5-y