Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Irit Sagi"'
Autor:
Alon Nudelman, Anjana Shenoy, Hyla Allouche-Arnon, Michal Fisler, Irit Rosenhek-Goldian, Lior Dayan, Paula Abou Karam, Ziv Porat, Inna Solomonov, Neta Regev-Rudzki, Amnon Bar-Shir, Irit Sagi
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 434 (2024)
Proteolysis of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a crucial role in the immune response to bacterial infections. Here we report the secretion of MMPs associated with proteolytic extracellular vesicles (EVs) relea
Externí odkaz:
https://doaj.org/article/b0a5d6ff48364c648a48f59bc6e7c9ef
Autor:
Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menachem Mendel Percia, Ran Ben Ezer, Maxim N. Shokhirev, Fan Qiu, Simon Schafer, Abed AlFatah Mansour, Kile P. Mangan, Tchelet Stern, Polina Ofer, Yam Stern, Ana Paula Diniz Mendes, Jose Djamus, Lynne Randolph Moore, Ritu Nayak, Sapir Havusha Laufer, Aidan Aicher, Amanda Rhee, Thomas L. Wong, Thao Nguyen, Sara B. Linker, Beate Winner, Beatriz C. Freitas, Eugenia Jones, Irit Sagi, Cedric Bardy, Alexis Brice, Juergen Winkler, Maria C. Marchetto, Fred H. Gage
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monol
Externí odkaz:
https://doaj.org/article/2fa050a5687248eaa0da9d23e96a5eb4
Autor:
Ellen M. Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J. Fleishman, Irit Sagi, Martina Havenith
Publikováno v:
JACS Au, Vol 1, Iss 7, Pp 1076-1085 (2021)
Externí odkaz:
https://doaj.org/article/678d581f417f468695ec2be3bec3b018
Autor:
Kwanghee Kim, Wenhuo Hu, François Audenet, Nima Almassi, Aphrothiti J. Hanrahan, Katie Murray, Aditya Bagrodia, Nathan Wong, Timothy N. Clinton, Shawn Dason, Vishnu Mohan, Sylvia Jebiwott, Karan Nagar, Jianjiong Gao, Alex Penson, Chris Hughes, Benjamin Gordon, Ziyu Chen, Yiyu Dong, Philip A. Watson, Ricardo Alvim, Arijh Elzein, Sizhi P. Gao, Emiliano Cocco, Alessandro D. Santin, Irina Ostrovnaya, James J. Hsieh, Irit Sagi, Eugene J. Pietzak, A. Ari Hakimi, Jonathan E. Rosenberg, Gopa Iyer, Herbert A. Vargas, Maurizio Scaltriti, Hikmat Al-Ahmadie, David B. Solit, Jonathan A. Coleman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The advancement of upper tract urothelial carcinoma (UTUC) research is hampered by the lack of disease-specific models. Here, the authors report patient derived xenograft and cell line models of UTUC, and show that these models retain the genomic and
Externí odkaz:
https://doaj.org/article/21deaeb5b9144f9aa0be74b0bca108b3
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The Hippo signaling pathway has been shown to be involved in regulating cellular identity, cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a kinase cascade which determines the nucleo-cytoplasmic localization of YA
Externí odkaz:
https://doaj.org/article/a0af310f4c8d4e5594f518bacc7fabde
Autor:
Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-19 (2019)
Abstract Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an obligate requirement by oncogenic KRAS for the ADAM17 protease in LAC. In genetica
Externí odkaz:
https://doaj.org/article/651450bcc02047a78683c22380e772e6
Autor:
Hila Gutman, Moshe Aftalion, Sharon Melamed, Boaz Politi, Reinat Nevo, Sapir Havusha-Laufer, Hagit Achdout, David Gur, Tomer Israely, Shlomit Dachir, Emanuelle Mamroud, Irit Sagi, Yaron Vagima
Publikováno v:
Viruses, Vol 14, Iss 8, p 1627 (2022)
The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation characterized by cytokine storm and fulminant immune response of both resident and migrated immune cells, accelerating alveolar damage. In this work we identified memb
Externí odkaz:
https://doaj.org/article/c4f0aa4bf09e4facaa63f1efdc0040de
Autor:
Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and represents a major cause of morbidity and mortality worldwide. Lysyl oxidases (LOXs) drive covalent
Externí odkaz:
https://doaj.org/article/83cb3c671bac499ca08859b5d75d220c
Autor:
Lena Cohen, Irit Sagi, Einat Bigelman, Inna Solomonov, Anna Aloshin, Jeremy Ben-Shoshan, Zach Rozenbaum, Gad Keren, Michal Entin-Meer
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231202 (2020)
OBJECTIVE:Monoclonal antibody derivatives are promising drugs for the treatment of various diseases due to their high matrix metalloproteinases (MMP) active site specificity. We studied the effects of a novel antibody, SDS3, which specifically recogn
Externí odkaz:
https://doaj.org/article/2b77052706a64fba914512b4b41d6fee
Autor:
Lena Cohen, Irit Sagi, Einat Bigelman, Inna Solomonov, Anna Aloshin, Jeremy Ben-Shoshan, Metsada Pasmanik-Chor, Zach Rozenbaum, Gad Keren, Michal Entin-Meer
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241419 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0231202.].
Externí odkaz:
https://doaj.org/article/1c1b7543b602481c8f1f651a40d8315a