Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Irit Lax"'
Autor:
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke
Publikováno v:
eLife, Vol 3 (2014)
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineat
Externí odkaz:
https://doaj.org/article/5fea7649da76453ba6611429febbdc74
Autor:
Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia, gastrointestinal stromal tum
Autor:
Seong J. An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Publikováno v:
Proceedings of the National Academy of Sciences. 120
While important insights were gained about how FGF21 and other endocrine fibroblast growth factors (FGFs) bind to Klotho proteins, the exact mechanism of Klotho/FGF receptor assembly that drives receptor dimerization and activation has not been eluci
Autor:
Jianan Zhang, Daryl E. Klein, Yueyue Wang, S.E. Stayrook, Ian X. Walker, Olivia Belliveau, Irit Lax, Andrew Proffitt, Krishna C. Mudumbi, Mansoor Ahmed, Diego Alvarado, Hengyi Li, Mark A. Lemmon, Yoshihisa Suzuki, S.G. Krimmer, Tongqing Li, Joseph Schlessinger, Yuko Tsutsui
Publikováno v:
Nature
The proto-oncogene ALK encodes anaplastic lymphoma kinase, a receptor tyrosine kinase that is expressed primarily in the developing nervous system. After development, ALK activity is associated with learning and memory1 and controls energy expenditur
Autor:
Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
The receptor tyrosine kinase KIT and its ligand SCF are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia and mast cell leukemia, are driven by somatic ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b981cded905ea9dc717bb3d8d2127dbe
https://doi.org/10.1101/2022.09.08.506998
https://doi.org/10.1101/2022.09.08.506998
Autor:
Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Alexander G. Myasnikov, Darcie J. Miller, Irit Lax, Joseph Schlessinger, Paolo Rossi, Andrey V. Reshetnyak, Charalampos G. Kalodimos
Publikováno v:
Nature
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system1,2. The ALK gene is a hotspot for chromosomal translocation events that result in several fusion proteins that cause
Autor:
Peter Man-Un Ung, Irit Lax, Ekaterina S. Kuzina, Sangwon Lee, Avner Schlessinger, Jan Steyaert, Francisco Tome, Jyotidarsini Mohanty, Els Pardon, Joseph Schlessinger, Jungyuen Choi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7819-7824
The three members of the endocrine fibroblast growth factor (FGF) family designated FGF19, FGF21, and FGF23 mediate their pleiotropic cellular effects by binding to and activating binary complexes composed of an FGF receptor (FGFR) bound to either α
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho
Autor:
Irit Lax, Jyotidarsini Mohanty, Yansheng Liu, Joseph Schlessinger, Francisco Tome, Wenxue Li, Sangwon Lee, Yoshihisa Suzuki, Seong An, Ekaterina S. Kuzina
Publikováno v:
Proc Natl Acad Sci U S A
The three members of the endocrine-fibroblast growth factor (FGF) family, FGF19, 21, and 23 are circulating hormones that regulate critical metabolic processes. FGF23 stimulates the assembly of a signaling complex composed of α-Klotho (KLA) and FGF
Autor:
Andrey V. Reshetnyak, Navjot Kaur, David E. Puleo, Mansoor Ahmed, Anton Poliakov, Alexander N. Plotnikov, Francisco Tome, Joseph Schlessinger, Jyotidarsini Mohanty, Irit Lax, Arul M. Cinnaiyan
Elucidating the physiological roles and modes of action of the recently discovered ligands (designated ALKAL1,2 or AUG-α,β) of the receptor tyrosine kinases Anaplastic Lymphoma Kinase (ALK) and Leukocyte Tyrosine Kinase (LTK) has been limited by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afaee2d35c44ce508c4d87139b69053
https://europepmc.org/articles/PMC6099872/
https://europepmc.org/articles/PMC6099872/
Autor:
Sangwon Lee, Jungyuen Choi, Jyotidarsini Mohanty, Leiliane P. Sousa, Francisco Tome, Els Pardon, Jan Steyaert, Mark A. Lemmon, Irit Lax, Joseph Schlessinger
Canonical fibroblast growth factors (FGFs) activate FGF receptors (FGFRs) through paracrine or autocrine mechanisms in a process that requires cooperation with heparan sulfate proteoglycans, which function as co-receptors for FGFR activation. By cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1ffc8578a59fc589e666f513015207
https://europepmc.org/articles/PMC6594174/
https://europepmc.org/articles/PMC6594174/