Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Iris Verbinnen"'
Autor:
Iris Verbinnen, Emilio Monte-Boquet, Detlev Parow, Fabienne Lacombe, Andrew Pothecary, Arno W. R. van Kuijk, Laura Harrington, Edita Müllerová, Andreas Pinter, Ulrike Erstling, Andrea Tomasini, Philip S. Helliwell
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 3, Pp 795-815 (2024)
Abstract Introduction Psoriatic arthritis (PsA) is a complex, progressive, and often debilitating disease. Despite recent advances in treatment, numerous unmet needs in patient care persist. Rheumacensus is a multistakeholder, pan-European initiative
Externí odkaz:
https://doaj.org/article/177ca0c0dd2a494c9e8e59080661e07b
Autor:
Iris Verbinnen, Sara S. Procknow, Lisa Lenaerts, Sara Reynhout, Aujan Mehregan, Chris Ulens, Veerle Janssens, Katherine A. King
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
PP2A-related (neuro) developmental disorders are a family of genetic diseases caused by a heterozygous alteration in one of several genes encoding a subunit of type 2A protein phosphatases. Reported affected genes, so far, are PPP2R5D, encoding the P
Externí odkaz:
https://doaj.org/article/2d623b682c10495e8eb5dbcf0c3502dc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Reversible protein phosphorylation is a fundamental regulation mechanism in eukaryotic cell and organismal physiology, and in human health and disease. Until recently, and unlike protein kinases, mutations in serine/threonine protein phosphatases (PS
Externí odkaz:
https://doaj.org/article/652110a7a8294a96a5e2363b2d0a43ea
Autor:
Louise Van Wijk, Shannah Boens, Aleyde Van Eynde, Mathieu Bollen, Iris Verbinnen, Mónica Ferreira, Kathelijne Szekér
Publikováno v:
Oncogenesis, Vol 9, Iss 3, Pp 1-8 (2020)
Oncogenesis
Oncogenesis
Nuclear Inhibitor of PP1 (NIPP1) is a conserved regulatory subunit of protein phosphatase PP1. The selective deletion of NIPP1 in mouse liver parenchymal cells or skin epidermal cells culminates in a late-onset hyperproliferation of a subset of resid
Autor:
Pieter Vaneynde, Lisa Lenaerts, Gunnar Houge, Rita Derua, Veerle Janssens, Iris Verbinnen, Sara Reynhout
By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in cellular signalling and physiology, including in brain function and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670714417d66504dca3b1eae7430317c
https://lirias.kuleuven.be/handle/123456789/677602
https://lirias.kuleuven.be/handle/123456789/677602
Publikováno v:
Journal of Biological Chemistry. 293:18031-18039
Germ cell proliferation is epigenetically controlled, mainly through DNA methylation and histone modifications. However, the pivotal epigenetic regulators of germ cell self-renewal and differentiation in postnatal testis are still poorly defined. The
Autor:
Margareta Nikolic, Mathieu Bollen, Raphael Rouget, Marloes C. M. Jonkhout, Mónica Ferreira, Shannah Boens, Aleyde Van Eynde, Kifayathullah Liakath-Ali, Kathelijne Szekér, Susan M. Schlenner, Iris Verbinnen
Publikováno v:
J Invest Dermatol
Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a ubiquitously expressed nuclear protein that regulates functions of protein serine/threonine phosphatase-1 in cell proliferation and lineage specification. The role of NIPP1 in tissue homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e3630612c4effcc8c41def4dcb0afe
https://lirias.kuleuven.be/handle/123456789/649048
https://lirias.kuleuven.be/handle/123456789/649048
Autor:
Amy McTague, Siddharth Srivastava, Tamison Jewett, Ali Al-Beshri, Constance Smith-Hicks, Shelagh Joss, Jennifer A. Sullivan, Sarju G. Mehta, Koenraad Devriendt, Pascal Joset, Laurence Faivre, Emma Kivuva, William G. Wilson, Gunnar Houge, Naama Orenstein, Yana Hoorne, Vickie L. Hannig, Malou Heijligers, Bart Loeys, Vandana Shashi, Katrina Prescott, Iris Verbinnen, Annick Toutain, Lauren M. Baldwin, Stephen P. Fulton, Katharina Steindl, Anne Marie Childs, Anna Chassevent, Shelley Towner, Cornelia Daumer-Haas, Oded Wechsberg, Alison Male, Hannah F. Johnson, Wendy K. Chung, Anita Rauch, Anna Ruiz, Isabelle Maystadt, Sara Reynhout, Sébastien Moutton, Yvette van Ierland, Veerle Janssens, Frédéric Laumonnier, Martina Baethmann, Lisa Lenaerts, Vani Jain, Vinod Varghese, Suzanne M. Koudijs, Elisabeth Gabau, Frédérique Bonnet-Brilhault, Rizwan Hamid, Susan E. Holder, Barbara Plecko
Publikováno v:
Genetics in Medicine, 23(2), 352-362. Nature Publishing Group
Genetics in Medicine
Genetics in Medicine, Nature Publishing Group, 2021, 23 (2), pp.352-362. ⟨10.1038/s41436-020-00981-2⟩
Genetics in Medicine, 23(2), 352-362. Lippincott Williams & Wilkins
Genetics in Medicine, 2021, 23 (2), pp.352-362. ⟨10.1038/s41436-020-00981-2⟩
Genetics in medicine
Genetics in Medicine
Genetics in Medicine, Nature Publishing Group, 2021, 23 (2), pp.352-362. ⟨10.1038/s41436-020-00981-2⟩
Genetics in Medicine, 23(2), 352-362. Lippincott Williams & Wilkins
Genetics in Medicine, 2021, 23 (2), pp.352-362. ⟨10.1038/s41436-020-00981-2⟩
Genetics in medicine
PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1563bdcdf43463d5995297a78f9c2f2
https://ddd.uab.cat/record/238621
https://ddd.uab.cat/record/238621
Publikováno v:
Biochemical Society Transactions. 45:89-99
Protein phosphatase 1 (PP1) is expressed in all eukaryotic cells and catalyzes a substantial fraction of phosphoserine/threonine dephosphorylation reactions. It forms stable complexes with PP1-interacting proteins (PIPs) that guide the phosphatase th
Autor:
Kathelijne Szekér, Shannah Boens, Margarida Fardilha, Aleyde Van Eynde, Mónica Ferreira, Iris Verbinnen, Mathieu Bollen, Claudia Winkler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
NIPP1 is one of the major nuclear interactors of protein phosphatase PP1. The deletion of NIPP1 in mice is early embryonic lethal, which has precluded functional studies in adult tissues. Hence, we have generated an inducible NIPP1 knockout model usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26804ca7efc108066355a54a94c328aa
https://lirias.kuleuven.be/handle/123456789/615289
https://lirias.kuleuven.be/handle/123456789/615289