Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Iris Ruf"'
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme’s function in the brain hold great promise for treating
Externí odkaz:
https://doaj.org/article/dde4fa8e6e8a4bb89ade3a42cbcce8bb
Autor:
Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammato
Externí odkaz:
https://doaj.org/article/d34faf86a82540f88518f79cdabc62d6
Autor:
Anna Lisa Gündner, Gonzalo Duran-Pacheco, Silke Zimmermann, Iris Ruf, Tim Moors, Karlheinz Baumann, Ravi Jagasia, Wilma D.J. van de Berg, Thomas Kremer
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 205-213 (2019)
Synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein in intraneuronal inclusions, named Lewy bodies. Mutations in GBA1, the gene encoding the lysosomal
Externí odkaz:
https://doaj.org/article/f283be9ad4f1434083071b1664441dc4
Autor:
Tim Moors, Iris Ruf, Anna Lisa Gündner, Silke Zimmermann, Wilma D.J. van de Berg, Karlheinz Baumann, Thomas Kremer, Gonzalo Duran-Pacheco, Ravi Jagasia
Publikováno v:
Gündner, A L, Duran-Pacheco, G, Zimmermann, S, Ruf, I, Moors, T, Baumann, K, Jagasia, R, van de Berg, W D J & Kremer, T 2019, ' Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels ', Neurobiology of Disease, vol. 121, pp. 205-213 . https://doi.org/10.1016/j.nbd.2018.09.015
Neurobiology of Disease, Vol 121, Iss, Pp 205-213 (2019)
Neurobiology of Disease, 121, 205-213. Academic Press Inc.
Neurobiology of Disease, Vol 121, Iss, Pp 205-213 (2019)
Neurobiology of Disease, 121, 205-213. Academic Press Inc.
Synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein in intraneuronal inclusions, named Lewy bodies. Mutations in GBA1, the gene encoding the lysosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e2bc2479f5f70c64c66123985fc584
https://research.vumc.nl/en/publications/d644942f-34f8-4562-ac4c-965f7fdfbdd8
https://research.vumc.nl/en/publications/d644942f-34f8-4562-ac4c-965f7fdfbdd8
Autor:
Anja Osterwald, Ponugoti Vasanth Rao, Pratap Challa, Leona Ho, Iris Ruf, Christoph Ullmer, Daniel Hunziker, Patrizio Mattei, Robin Vann
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Ocular hypertension due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM) is a major risk factor for glaucoma, a leading cause of irreversible blindness. However, the etiology of ocular hypertension remains unclear. Althoug
Autor:
B. Ruf, Iris Ruf, Margareta Lindner, Joachim Beige, Susanne Weiß, Thomas Grünewald, Till Treutler
Publikováno v:
International Journal of Hygiene and Environmental Health. 216:751-754
Colonization with Staphylococci is widely distributed among patients with end-stage renal disease who are receiving hemodialysis (HD). In addition to more intensive care and use of artificial devices, the incidence of methicillin-resistant Staphyloco
Autor:
Martin Binder, Will Spooren, Simona M. Ceccarelli, Patrick Boissin, Steven P. Hanlon, Ernst Kupfer, Eric Prinssen, Andreas Stämpfli, Georg Jaeschke, Bernd Buettelmann, Iris Ruf, Jens-Uwe Peters, Eric Vieira, Sabine Kolczewski, Marianne Rueher, Porter Richard Hugh Phillip, Götz Schlotterbeck
Publikováno v:
ChemMedChem. 3:136-144
Detailed information on the metabolic fate of lead compounds can be a powerful tool for an informed approach to the stabilization of metabolically labile compounds in the lead optimization phase. The combination of high performance liquid chromatogra